TR200401075T4 - Hedef türlere bağlanan bileşikleri belirlemek için flüoresan korelasyon spektroskopisinin kullanımı - Google Patents
Hedef türlere bağlanan bileşikleri belirlemek için flüoresan korelasyon spektroskopisinin kullanımıInfo
- Publication number
- TR200401075T4 TR200401075T4 TR2004/01075T TR200401075T TR200401075T4 TR 200401075 T4 TR200401075 T4 TR 200401075T4 TR 2004/01075 T TR2004/01075 T TR 2004/01075T TR 200401075 T TR200401075 T TR 200401075T TR 200401075 T4 TR200401075 T4 TR 200401075T4
- Authority
- TR
- Turkey
- Prior art keywords
- target species
- test compound
- correlation spectroscopy
- fluorescence correlation
- bind
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/12—Condition responsive control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/13—Tracers or tags
Abstract
Mevcut bulus bir hedef üre baglanan bir test bilesiginin belirlenmesi için bir yöntem saglamaktadir. Yöntem asagidaki kademeleri içerir; en az bir test bilesiginin izotermal denatürasyon kosullari altinda kuluçkalanmasi, her bir test bilesigi ve en az bir hedef tür içerir burada izotermal denatürasyona ugramasina neden olacak kadar etkilidir; her bir hedef türünün denatürasyon sinyalinin en az bir test bilesigi varliginda hedef molekülün yayilma özelliklerindeki bir degisikligin flüoresan korelasyon spektroskopisinin kullanimi ile tespit edilmesi; ve her bir hedef türünün en az bir test bilesigi varliginda denatürasyon sinyalinin ayni hedef türünün en az bir test bilesigi yoklugunda ayni izotermal denatürasyon kosullari altindaki denatürasyon sinyalinin karsilastirilmasi.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/458,172 US6582907B1 (en) | 1999-12-09 | 1999-12-09 | Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200401075T4 true TR200401075T4 (tr) | 2004-07-21 |
Family
ID=23819671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/01075T TR200401075T4 (tr) | 1999-12-09 | 2000-12-07 | Hedef türlere bağlanan bileşikleri belirlemek için flüoresan korelasyon spektroskopisinin kullanımı |
Country Status (13)
Country | Link |
---|---|
US (2) | US6582907B1 (tr) |
EP (1) | EP1236047B1 (tr) |
JP (1) | JP2003517609A (tr) |
AT (1) | ATE265684T1 (tr) |
AU (1) | AU777163B2 (tr) |
CA (1) | CA2392239A1 (tr) |
DE (1) | DE60010323T2 (tr) |
DK (1) | DK1236047T3 (tr) |
ES (1) | ES2218280T3 (tr) |
HK (1) | HK1047158B (tr) |
PT (1) | PT1236047E (tr) |
TR (1) | TR200401075T4 (tr) |
WO (1) | WO2001044817A2 (tr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
US6517781B1 (en) * | 1997-06-02 | 2003-02-11 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
DE10013854A1 (de) * | 2000-03-17 | 2001-09-20 | Zeiss Carl Jena Gmbh | Anordnung und Verfahren zur Untersuchung von Wirkstoffen zur Beeinflussung intrazellulärer Vorgänge |
EP1468116A2 (en) | 2002-01-16 | 2004-10-20 | Dynal Biotech ASA | Method for isolating nucleic acids and protein from a single sample |
CN1662810A (zh) * | 2002-06-21 | 2005-08-31 | 奥林巴斯株式会社 | 生物分子分析装置 |
US7268878B2 (en) * | 2002-08-01 | 2007-09-11 | Sensor Technologies Llc | Fluorescence correlation spectroscopy instrument and method of using the same |
GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
WO2006013109A1 (en) * | 2004-08-06 | 2006-02-09 | Epfl Swiss Federal Institute Of Technology-Lausanne | Method for testing a substance interacting with a target molecule |
WO2006087727A1 (en) * | 2005-02-15 | 2006-08-24 | Tata Institute Of Fundamental Research | Fluorescence correlation microscopy with real-time alignment readout |
DE102007045666A1 (de) * | 2007-09-25 | 2009-04-02 | Carl Zeiss Microimaging Gmbh | Verfahren und Anordnung zur Ausgabe von Restfehlern einer an eine Punktemenge angepassten Funktion |
KR100963305B1 (ko) | 2008-01-23 | 2010-06-11 | 건국대학교 산학협력단 | 단백질 내의 도메인 간 변성과정 분석방법 |
US20210272656A1 (en) * | 2020-02-28 | 2021-09-02 | Howard University | Selection extraction of late exponentials |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679582A (en) | 1993-06-21 | 1997-10-21 | Scriptgen Pharmaceuticals, Inc. | Screening method for identifying ligands for target proteins |
US5585277A (en) | 1993-06-21 | 1996-12-17 | Scriptgen Pharmaceuticals, Inc. | Screening method for identifying ligands for target proteins |
CA2184195C (en) | 1995-10-25 | 2002-04-16 | Andrew Pakula | Screening method for identifying ligands for target proteins |
WO1997020952A1 (en) | 1995-12-07 | 1997-06-12 | Scriptgen Pharmaceuticals, Inc. | A fluorescence-based screening method for identifying ligands |
US6020141A (en) | 1996-05-09 | 2000-02-01 | 3-Dimensional Pharmaceuticals, Inc. | Microplate thermal shift assay for ligand development and multi-variable protein chemistry optimization |
EP0836090A1 (en) | 1996-10-12 | 1998-04-15 | Evotec BioSystems GmbH | Method of analysis of samples by determination of the distribution of specific brightnesses of particles |
DK1036192T3 (da) | 1997-12-05 | 2003-06-10 | Upjohn Co | Fluorescensbaserede screeningsanalyser med høj hastighedforproteinkinaser og phosphataser |
US6242190B1 (en) | 1999-12-01 | 2001-06-05 | John Hopkins University | Method for high throughput thermodynamic screening of ligands |
US6376180B1 (en) * | 1999-12-09 | 2002-04-23 | Pharmacia & Upjohn Company | Methods of identifying compounds that bind to target species under isothermal denaturing conditions |
-
1999
- 1999-12-09 US US09/458,172 patent/US6582907B1/en not_active Expired - Fee Related
-
2000
- 2000-12-07 ES ES00992663T patent/ES2218280T3/es not_active Expired - Lifetime
- 2000-12-07 CA CA002392239A patent/CA2392239A1/en not_active Abandoned
- 2000-12-07 EP EP00992663A patent/EP1236047B1/en not_active Expired - Lifetime
- 2000-12-07 AU AU45198/01A patent/AU777163B2/en not_active Ceased
- 2000-12-07 JP JP2001545854A patent/JP2003517609A/ja active Pending
- 2000-12-07 PT PT00992663T patent/PT1236047E/pt unknown
- 2000-12-07 AT AT00992663T patent/ATE265684T1/de not_active IP Right Cessation
- 2000-12-07 WO PCT/US2000/042642 patent/WO2001044817A2/en active Search and Examination
- 2000-12-07 TR TR2004/01075T patent/TR200401075T4/tr unknown
- 2000-12-07 DK DK00992663T patent/DK1236047T3/da active
- 2000-12-07 DE DE60010323T patent/DE60010323T2/de not_active Expired - Fee Related
-
2002
- 2002-11-06 HK HK02108073.1A patent/HK1047158B/zh not_active IP Right Cessation
-
2003
- 2003-05-27 US US10/445,513 patent/US20030219820A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60010323T2 (de) | 2005-05-25 |
EP1236047B1 (en) | 2004-04-28 |
US20030219820A1 (en) | 2003-11-27 |
WO2001044817A3 (en) | 2002-05-10 |
AU777163B2 (en) | 2004-10-07 |
DE60010323D1 (de) | 2004-06-03 |
CA2392239A1 (en) | 2001-06-21 |
PT1236047E (pt) | 2004-08-31 |
WO2001044817A2 (en) | 2001-06-21 |
JP2003517609A (ja) | 2003-05-27 |
DK1236047T3 (da) | 2004-07-05 |
US6582907B1 (en) | 2003-06-24 |
ES2218280T3 (es) | 2004-11-16 |
ATE265684T1 (de) | 2004-05-15 |
HK1047158A1 (en) | 2003-02-07 |
EP1236047A2 (en) | 2002-09-04 |
HK1047158B (zh) | 2004-12-03 |
AU4519801A (en) | 2001-06-25 |
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