PT1236047E - Espectroscopia de correlacao de fluorescencia para identificar compostos de a alvos - Google Patents

Espectroscopia de correlacao de fluorescencia para identificar compostos de a alvos

Info

Publication number
PT1236047E
PT1236047E PT00992663T PT00992663T PT1236047E PT 1236047 E PT1236047 E PT 1236047E PT 00992663 T PT00992663 T PT 00992663T PT 00992663 T PT00992663 T PT 00992663T PT 1236047 E PT1236047 E PT 1236047E
Authority
PT
Portugal
Prior art keywords
target species
test compound
fluorescence correlation
spectroscopy
denaturing conditions
Prior art date
Application number
PT00992663T
Other languages
English (en)
Inventor
Dennis E Epps
Paul K Tomich
Ferenc J Kezdy
Charles K Marschke
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PT1236047E publication Critical patent/PT1236047E/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/12—Condition responsive control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
PT00992663T 1999-12-09 2000-12-07 Espectroscopia de correlacao de fluorescencia para identificar compostos de a alvos PT1236047E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/458,172 US6582907B1 (en) 1999-12-09 1999-12-09 Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions

Publications (1)

Publication Number Publication Date
PT1236047E true PT1236047E (pt) 2004-08-31

Family

ID=23819671

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00992663T PT1236047E (pt) 1999-12-09 2000-12-07 Espectroscopia de correlacao de fluorescencia para identificar compostos de a alvos

Country Status (13)

Country Link
US (2) US6582907B1 (pt)
EP (1) EP1236047B1 (pt)
JP (1) JP2003517609A (pt)
AT (1) ATE265684T1 (pt)
AU (1) AU777163B2 (pt)
CA (1) CA2392239A1 (pt)
DE (1) DE60010323T2 (pt)
DK (1) DK1236047T3 (pt)
ES (1) ES2218280T3 (pt)
HK (1) HK1047158B (pt)
PT (1) PT1236047E (pt)
TR (1) TR200401075T4 (pt)
WO (1) WO2001044817A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
US6517781B1 (en) * 1997-06-02 2003-02-11 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
DE10013854A1 (de) * 2000-03-17 2001-09-20 Zeiss Carl Jena Gmbh Anordnung und Verfahren zur Untersuchung von Wirkstoffen zur Beeinflussung intrazellulärer Vorgänge
WO2003062462A2 (en) 2002-01-16 2003-07-31 Dynal Biotech Asa Method for isolating nucleic acids and protein from a single sample
AU2003244122A1 (en) 2002-06-21 2004-01-06 Olympus Corporation Biomolecule analyzer
EP1546675A4 (en) * 2002-08-01 2008-03-26 Sensor Technologies Inc METHOD FOR MEASURING MOLECULAR INTERACTIONS
GB0229287D0 (en) * 2002-12-16 2003-01-22 Dna Res Innovations Ltd Polyfunctional reagents
WO2006013109A1 (en) * 2004-08-06 2006-02-09 Epfl Swiss Federal Institute Of Technology-Lausanne Method for testing a substance interacting with a target molecule
WO2006087727A1 (en) * 2005-02-15 2006-08-24 Tata Institute Of Fundamental Research Fluorescence correlation microscopy with real-time alignment readout
DE102007045666A1 (de) * 2007-09-25 2009-04-02 Carl Zeiss Microimaging Gmbh Verfahren und Anordnung zur Ausgabe von Restfehlern einer an eine Punktemenge angepassten Funktion
KR100963305B1 (ko) 2008-01-23 2010-06-11 건국대학교 산학협력단 단백질 내의 도메인 간 변성과정 분석방법
US20210272656A1 (en) * 2020-02-28 2021-09-02 Howard University Selection extraction of late exponentials

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679582A (en) 1993-06-21 1997-10-21 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5585277A (en) 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
CA2184195C (en) 1995-10-25 2002-04-16 Andrew Pakula Screening method for identifying ligands for target proteins
CA2236339A1 (en) 1995-12-07 1997-06-12 Robert T. Sauer A fluorescence-based screening method for identifying ligands
HUP9902418A3 (en) 1996-05-09 2001-10-29 Dimensional Pharm Inc Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
EP0836090A1 (en) 1996-10-12 1998-04-15 Evotec BioSystems GmbH Method of analysis of samples by determination of the distribution of specific brightnesses of particles
WO1999029894A1 (en) 1997-12-05 1999-06-17 Pharmacia & Upjohn Company Fluorescence-based high throughput screening assays for protein kinases and phosphatases
US6242190B1 (en) 1999-12-01 2001-06-05 John Hopkins University Method for high throughput thermodynamic screening of ligands
US6376180B1 (en) * 1999-12-09 2002-04-23 Pharmacia & Upjohn Company Methods of identifying compounds that bind to target species under isothermal denaturing conditions

Also Published As

Publication number Publication date
AU777163B2 (en) 2004-10-07
JP2003517609A (ja) 2003-05-27
TR200401075T4 (tr) 2004-07-21
WO2001044817A2 (en) 2001-06-21
HK1047158A1 (en) 2003-02-07
EP1236047B1 (en) 2004-04-28
EP1236047A2 (en) 2002-09-04
DK1236047T3 (da) 2004-07-05
US6582907B1 (en) 2003-06-24
DE60010323D1 (de) 2004-06-03
US20030219820A1 (en) 2003-11-27
CA2392239A1 (en) 2001-06-21
AU4519801A (en) 2001-06-25
ATE265684T1 (de) 2004-05-15
HK1047158B (zh) 2004-12-03
ES2218280T3 (es) 2004-11-16
DE60010323T2 (de) 2005-05-25
WO2001044817A3 (en) 2002-05-10

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