TR200002427T2 - New compounds and their use as positive ampa receptor modulators. - Google Patents
New compounds and their use as positive ampa receptor modulators.Info
- Publication number
- TR200002427T2 TR200002427T2 TR2000/02427T TR200002427T TR200002427T2 TR 200002427 T2 TR200002427 T2 TR 200002427T2 TR 2000/02427 T TR2000/02427 T TR 2000/02427T TR 200002427 T TR200002427 T TR 200002427T TR 200002427 T2 TR200002427 T2 TR 200002427T2
- Authority
- TR
- Turkey
- Prior art keywords
- ampa receptor
- new compounds
- receptor modulators
- positive ampa
- positive
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
- C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
- C07D285/28—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Bu bulus, kesik hat ile temsil edilen bagin bir tekil veya çift bag olabildigi veya mevcut olmayabildigi; ve bagin mevcut olmamasi durumunda nitrojenin hidrojen ve R2 ile ikameli oldugu; X' in SO2 veya C=O veya CH2 oldugu; Y' nin -CH(R4)-, -(R4)-veya -N(R4)-CH2-,O oldugu; ve R2,R3,R4,R5,R6,R7, ve R8' in anlamlarinin basvurudaki gibi oldugu genel formül Formül (I)ile ifade edilebilen bir bilesigi sunmaktadir. Bu bilesikler, AMPA reseptörünün pozitif modülatörleri olarak faydalidir.This invention may or may not be present in a single or double bond, represented by a broken line; and nitrogen is substituted with hydrogen and R2 if the bond is absent; X is SO2 or C = O or CH2; Y is -CH (R4) -, - (R4) -or -N (R4) -CH2-, O; and the general formula where the meanings of R2, R3, R4, R5, R6, R7, and R8 are as in the application presents a compound that can be expressed by Formula (I). These compounds are useful as positive modulators of the AMPA receptor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK22698 | 1998-02-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200002427T2 true TR200002427T2 (en) | 2001-01-22 |
Family
ID=8091151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/02427T TR200002427T2 (en) | 1998-02-18 | 1999-02-18 | New compounds and their use as positive ampa receptor modulators. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1071426A2 (en) |
JP (1) | JP2002504481A (en) |
CN (1) | CN1293665A (en) |
AU (1) | AU751384B2 (en) |
CA (1) | CA2320354A1 (en) |
EE (1) | EE200000468A (en) |
HU (1) | HUP0101280A3 (en) |
IL (1) | IL137720A0 (en) |
IS (1) | IS5581A (en) |
NO (1) | NO20004121L (en) |
NZ (1) | NZ506251A (en) |
PL (1) | PL342843A1 (en) |
RU (1) | RU2214405C2 (en) |
SK (1) | SK11892000A3 (en) |
TR (1) | TR200002427T2 (en) |
WO (1) | WO1999042456A2 (en) |
ZA (1) | ZA991301B (en) |
Families Citing this family (56)
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US7671200B2 (en) | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
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FR2812291B1 (en) * | 2000-07-28 | 2002-12-13 | Adir | NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
CN1314351A (en) * | 2001-03-22 | 2001-09-26 | 刘志红 | Process for synthesizing quinazolone and quinazolone compound with anti-cancer function |
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AU2002320841B2 (en) | 2001-06-14 | 2008-02-28 | Merck Sharp & Dohme B.V. | (Pyrido/thieno)-[f]-oxazepin-5-one derivatives as positive modulators of the AMPA receptor |
CA2458388A1 (en) | 2001-10-10 | 2003-04-17 | Neurosearch A/S | Novel benzothiazine derivatives, their preparation and use |
US7799913B2 (en) * | 2001-11-26 | 2010-09-21 | Cortex Pharmaceuticals, Inc. | Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses |
FR2833955B1 (en) | 2001-12-21 | 2004-01-30 | Servier Lab | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
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NZ331549A (en) * | 1996-01-29 | 2000-09-29 | Univ California | Compounds useful in treating sexual dysfunction |
AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
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1999
- 1999-02-18 RU RU2000121882/04A patent/RU2214405C2/en not_active IP Right Cessation
- 1999-02-18 WO PCT/DK1999/000070 patent/WO1999042456A2/en not_active Application Discontinuation
- 1999-02-18 ZA ZA9901301A patent/ZA991301B/en unknown
- 1999-02-18 EE EEP200000468A patent/EE200000468A/en unknown
- 1999-02-18 AU AU25123/99A patent/AU751384B2/en not_active Ceased
- 1999-02-18 CN CN99804196A patent/CN1293665A/en active Pending
- 1999-02-18 SK SK1189-2000A patent/SK11892000A3/en unknown
- 1999-02-18 HU HU0101280A patent/HUP0101280A3/en unknown
- 1999-02-18 IL IL13772099A patent/IL137720A0/en unknown
- 1999-02-18 JP JP2000532408A patent/JP2002504481A/en not_active Withdrawn
- 1999-02-18 NZ NZ506251A patent/NZ506251A/en unknown
- 1999-02-18 EP EP99904730A patent/EP1071426A2/en not_active Withdrawn
- 1999-02-18 PL PL99342843A patent/PL342843A1/en unknown
- 1999-02-18 TR TR2000/02427T patent/TR200002427T2/en unknown
- 1999-02-18 CA CA002320354A patent/CA2320354A1/en not_active Abandoned
-
2000
- 2000-08-04 IS IS5581A patent/IS5581A/en unknown
- 2000-08-17 NO NO20004121A patent/NO20004121L/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2214405C2 (en) | 2003-10-20 |
NO20004121D0 (en) | 2000-08-17 |
AU751384B2 (en) | 2002-08-15 |
IL137720A0 (en) | 2001-10-31 |
SK11892000A3 (en) | 2001-02-12 |
NZ506251A (en) | 2003-01-31 |
CN1293665A (en) | 2001-05-02 |
EP1071426A2 (en) | 2001-01-31 |
HUP0101280A2 (en) | 2001-10-28 |
CA2320354A1 (en) | 1999-08-26 |
ZA991301B (en) | 1999-09-13 |
NO20004121L (en) | 2000-10-17 |
EE200000468A (en) | 2002-04-15 |
PL342843A1 (en) | 2001-07-16 |
AU2512399A (en) | 1999-09-06 |
HUP0101280A3 (en) | 2003-02-28 |
WO1999042456A3 (en) | 1999-10-07 |
WO1999042456A2 (en) | 1999-08-26 |
IS5581A (en) | 2000-08-04 |
JP2002504481A (en) | 2002-02-12 |
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