HUP0101280A2 - Positive ampa receptor modulator compounds and their use - Google Patents

Positive ampa receptor modulator compounds and their use

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Publication number
HUP0101280A2
HUP0101280A2 HU0101280A HUP0101280A HUP0101280A2 HU P0101280 A2 HUP0101280 A2 HU P0101280A2 HU 0101280 A HU0101280 A HU 0101280A HU P0101280 A HUP0101280 A HU P0101280A HU P0101280 A2 HUP0101280 A2 HU P0101280A2
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HU
Hungary
Prior art keywords
group
alkyl
optionally substituted
hydrogen atom
formula
Prior art date
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HU0101280A
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Hungarian (hu)
Inventor
Alex Haahr Gouliaev
Tina Holm Johansen
Mogens Larsen
Claus Mathiesen
Elsebet Nielsen
Gunnar M. Olsen
Jörgen Scheel-Krüger
Thomas Varming
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Neurosearch A/S
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Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of HUP0101280A2 publication Critical patent/HUP0101280A2/en
Publication of HUP0101280A3 publication Critical patent/HUP0101280A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
    • C07D285/28—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

A találmány szerinti (I') általános képletében X jelentése C=O vagyCH2, SO2; Y jelentése CH(R4), N(R4), N(R4)-CH2 vagy oxigénatom, R2jelentése hidrogénatom, alkilcsoport, cikloalkilcsoport, arilcsoport,benzilcsoport vagy -CO-R9 képletű csoport, vagy R2 és R3 jelentése akapcsolódó atomokkal együtt adott esetben szubsztituált heterociklusoscsoport, R3 jelentése hidrogénatom, -cikloalkilcsoport, alkilcsoport,cikloalkilalkil-csoport, halogénalkilcsoport; hidroxialkilcsoport,cianoalkilcsoport, alkoxialkilcsoport; alkoxicsoport,halogénalkoxicsoport, alkilcsoport, -alkil-NR13R14 vagy -alkil-S-R13képletű csoport - vagy R3 jelentése adott esetben szubsztituáltkarbociklusos gyűrű, adott esetben szubsztituált heterociklusos gyűrű,adott esetben szubsztituált benzilcsoport vagy adott esetbenszubsztituált arilcsoport vagy R3 és R4 jelentése a kapcsolódóatomokkal együtt adott esetben szubsztituált heterociklusos csoport,R4 jelentése hidrogénatom, alkilcsoport, cikloalkilcsoport,cikloalkilalkil-csoport, arilcsoport, -CO-R10 vagy -CO2-R10 képletűcsoport, R5 jelentése hidrogénatom, halogénatom, alkilcsoport,alkenilcsoport, alkinilcsoport vagy arilcsoport, vagy -SO2-NR11R12képletű csoport, R6 jelentése hidrogénatom, halogénatom, alkilcsoport,cianocsoport, cianoalkilcsoport, nitrocsoport, alkoxicsoport,halogénalkoxicsoport, halogénalkilcsoport, hidroxialkilcsoport,cikloalkilcsoport vagy ciklohalogénalkilcsoport, vagy -NR15R16, -NHSO2R15 vagy -NHSO2-aril képletű csoport, adott esetben szubsztituáltarilcsoport, adott esetben szubsztituált HET, vagy -(alkil)m-S-R15, -(alkil)m-SO-R15, -(alkil)m-SO2-R15, -(alkil)m- SO2OR15, -(alkil)m-SO2NR15R16, -(alkil)m-NHCOR15, -(alkil)m-CONR15R16, -(alkil)m-CR'=NOR", -(alkil)m-CO-R15 vagy -(alkil)m-CO2R15 képletű csoport; R7jelentése hidrogénatom, halogénatom, alkilcsoport, cianocsoport,cianoalkilcsoport, nitrocsoport, nitroalkilcsoport, alkoxicsoport,halogénalkoxicsoport, halogénalkilcsoport, hidroxialkilcsoport,cikloalkilcsoport vagy ciklohalogénalkilcsoport, vagy -NR17R18, -NHSO2R17 vagy -NHSO2-aril képletű csoport, -(alkil)m-S-R17, -(alkil)m-SO-R17, -(alkil)m-SO2R17, -(alkil)m-SO2OR17, -(alkil)m-SO2NR17R18, -(alkil)m-NHCOR17, -(alkil)m-CONR17R18, -(alkil)m-CR'=NOR", -(alkil)m-CO-R17 vagy -(alkil)m-CO2R17 képletű csoport, adott esetbenszubsztituált HET vagy adott esetben szubsztituált arilcsoport, vagyR7 és R6 vagy R8 jelentése együtt adott esetben szubsztituált gyűrű,R8 jelentése hidrogénatom, alkilcsoport, alkoxicsoport,hidroxialkilcsoport, halogénatom, halogénalkilcsoport, cianocsoport,cianoalkilcsoport, nitrocsoport, nitroalkilcsoport, adott esetbenszubsztituált arilcsoport, adott esetben szubsztituált HET, vagy -(alkil)m-S-R19, -(alkil)m-SO-R19, -(alkil)m-SO2-R19, -(alkil)m-SO2OR19, -(alkil)m-SO2NR19R20, -(alkil)m-NHCOR19 ,In the general formula (I') according to the invention, X is C=O or CH2, SO2; Y means CH(R4), N(R4), N(R4)-CH2 or an oxygen atom, R2 means a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, a benzyl group or a group of the formula -CO-R9, or R2 and R3 mean together with the connected atoms optionally substituted heterocyclic group, R3 is a hydrogen atom, -cycloalkyl group, alkyl group, cycloalkylalkyl group, haloalkyl group; hydroxyalkyl group, cyanoalkyl group, alkoxyalkyl group; Alkoxy group, haloalkoxy group, alkyl group, group of the formula -alkyl-NR13R14 or -alkyl-S-R13 - or R3 means optionally substituted carbocyclic ring, optionally substituted heterocyclic ring, optionally substituted benzyl group or optionally substituted aryl group or R3 and R4 have the meanings given together with the attached atoms substituted heterocyclic group, R4 is hydrogen atom, alkyl group, cycloalkyl group, cycloalkylalkyl group, aryl group, -CO-R10 or -CO2-R10 group, R5 is hydrogen atom, halogen atom, alkyl group, alkenyl group, alkynyl group or aryl group, or -SO2-NR11R12 group . or -(alkyl)m-S-R15, -(alkyl)m-SO-R15, -(alkyl)m-SO2-R15, -(alkyl)m- SO2OR15, -(alkyl)m-SO2NR15R16, -(alkyl)m a group of formula -NHCOR15, -(alkyl)m-CONR15R16, -(alkyl)m-CR'=NOR", -(alkyl)m-CO-R15 or -(alkyl)m-CO2R15; R7 means a hydrogen atom, a halogen atom, an alkyl group, a cyano group, a cyanoalkyl group, a nitro group, a nitroalkyl group, an alkoxy group, a haloalkyl group, a haloalkyl group, a hydroxyalkyl group, a cycloalkyl group or a cyclohaloalkyl group, or a group of the formula -NR17R18, -NHSO2R17 or -NHSO2-aryl, -(alkyl)m-S-R17, - (alkyl)m-SO-R17, -(alkyl)m-SO2R17, -(alkyl)m-SO2OR17, -(alkyl)m-SO2NR17R18, -(alkyl)m-NHCOR17, -(alkyl)m-CONR17R18, - (alkyl)m-CR'=NOR", a group of formula -(alkyl)m-CO-R17 or -(alkyl)m-CO2R17, optionally substituted HET or optionally substituted aryl group, or R7 and R6 or R8 together optionally substituted ring, R8 is a hydrogen atom, an alkyl group, an alkoxy group, a hydroxyalkyl group, a halogen atom, a haloalkyl group, a cyano group, a cyanoalkyl group, a nitro group, a nitroalkyl group, an optionally substituted aryl group, an optionally substituted HET, or -(alkyl)m-S-R19, -(alkyl)m-SO- R19, -(alkyl)m-SO2-R19, -(alkyl)m-SO2OR19, -(alkyl)m-SO2NR19R20, -(alkyl)m-NHCOR19,

HU0101280A 1998-02-18 1999-02-18 Positive ampa receptor modulator compounds and their use HUP0101280A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK22698 1998-02-18
PCT/DK1999/000070 WO1999042456A2 (en) 1998-02-18 1999-02-18 Novel compounds and their use as positive ampa receptor modulators

Publications (2)

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HUP0101280A2 true HUP0101280A2 (en) 2001-10-28
HUP0101280A3 HUP0101280A3 (en) 2003-02-28

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EP (1) EP1071426A2 (en)
JP (1) JP2002504481A (en)
CN (1) CN1293665A (en)
AU (1) AU751384B2 (en)
CA (1) CA2320354A1 (en)
EE (1) EE200000468A (en)
HU (1) HUP0101280A3 (en)
IL (1) IL137720A0 (en)
IS (1) IS5581A (en)
NO (1) NO20004121L (en)
NZ (1) NZ506251A (en)
PL (1) PL342843A1 (en)
RU (1) RU2214405C2 (en)
SK (1) SK11892000A3 (en)
TR (1) TR200002427T2 (en)
WO (1) WO1999042456A2 (en)
ZA (1) ZA991301B (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
DE10004572A1 (en) 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma New positive allosteric AMPA receptor modulators (PAARM), processes for their production and their use as medicines
FR2812291B1 (en) * 2000-07-28 2002-12-13 Adir NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN1314351A (en) * 2001-03-22 2001-09-26 刘志红 Process for synthesizing quinazolone and quinazolone compound with anti-cancer function
TWI232863B (en) * 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
AU2002320841B2 (en) 2001-06-14 2008-02-28 Merck Sharp & Dohme B.V. (Pyrido/thieno)-[f]-oxazepin-5-one derivatives as positive modulators of the AMPA receptor
CA2458388A1 (en) 2001-10-10 2003-04-17 Neurosearch A/S Novel benzothiazine derivatives, their preparation and use
US7799913B2 (en) * 2001-11-26 2010-09-21 Cortex Pharmaceuticals, Inc. Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
FR2833955B1 (en) 2001-12-21 2004-01-30 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2833950B1 (en) * 2001-12-21 2005-12-16 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2833956B1 (en) 2001-12-21 2004-01-30 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2854634B1 (en) 2003-05-05 2005-07-08 Servier Lab NOVEL THIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2856065B1 (en) * 2003-06-13 2005-08-19 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2856064B1 (en) * 2003-06-13 2005-08-19 Servier Lab NOVEL BENZOTHIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
RU2006102869A (en) 2003-07-02 2007-08-10 Ф.Хоффманн-Ля Рош Аг (Ch) Arylamino-substituted quinazolinone compounds
AU2004270161A1 (en) 2003-08-28 2005-03-17 Nicox S.A. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
US7244843B2 (en) 2003-10-07 2007-07-17 Bristol-Myers Squibb Company Modulators of serotonin receptors
FR2865474B1 (en) * 2004-01-26 2008-06-13 Servier Lab NOVEL FLUORINATED BENZOTHIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2877338B1 (en) 2004-11-03 2007-01-26 Servier Lab NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2877342B1 (en) * 2004-11-03 2007-01-26 Servier Lab NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2879201B1 (en) * 2004-12-10 2007-02-16 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
DE602006004964D1 (en) 2005-02-10 2009-03-12 Bristol Myers Squibb Co DIHYDROCHINAZOLINONE AS 5HT MODULATORS
JP2008531579A (en) 2005-02-24 2008-08-14 ニトロメッド インコーポレーティッド Nitric oxide enhanced diuretic compounds, compositions and methods of use
GB0507298D0 (en) * 2005-04-11 2005-05-18 Novartis Ag Organic compounds
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
ES2374995T3 (en) 2007-01-03 2012-02-23 Les Laboratoires Servier COMPOSITE OF [1,2,3] -BENZOTRIAZINONE 3-REPLACED TO IMPROVE GLUTAMATERGIC SYNAPTIC RESPONSES.
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
EA200901546A1 (en) 2007-05-17 2010-04-30 Кортекс Фармасеутикалс, Инк. DESIGNED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES
SG163526A1 (en) 2007-08-10 2010-08-30 Cortex Pharma Inc Bicyclic amides for enhancing glutamatergic synaptic responses
US8168632B2 (en) 2007-08-10 2012-05-01 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for the treatment of respiratory disorders
FR2933698A1 (en) 2008-07-09 2010-01-15 Servier Lab NOVEL CYCLOALKYLATED BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2943342B1 (en) 2009-03-20 2011-03-04 Servier Lab NOVEL BENZOTHIADIAZEPINES DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
SI2464645T1 (en) 2009-07-27 2017-10-30 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
FR2955107B1 (en) 2010-01-08 2012-03-02 Servier Lab NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2955106B1 (en) 2010-01-08 2011-12-23 Servier Lab NOVEL CYCLOPROPYLATED BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN102958919A (en) * 2010-07-02 2013-03-06 霍夫曼-拉罗奇有限公司 Novel tetrahydroquinoline derivatives
CN103096977B (en) 2010-07-02 2017-02-15 吉利德科学公司 Fused heterocyclic compounds as ion channel modulators
FR2964969B1 (en) * 2010-09-16 2012-08-24 Servier Lab NOVEL DIHYDROBENZOXATHIAZEPINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IT1402905B1 (en) * 2010-11-29 2013-09-27 Univ Degli Studi Modena E Reggio Emilia DERIVATIVES OF 1,2,4-BENZOTIADIAZIN 1,1-DIOXIDE, THEIR PREPARATION AND THEIR USE AS ALLOSTERIC MODULATORS OF THE AMPA RECEPTOR.
CN103649056B (en) 2011-05-10 2016-04-27 吉利德科学公司 As the condensed heterocyclic compouds of ion channel modulators
TW201837023A (en) 2011-07-01 2018-10-16 美商基利科學股份有限公司 Fused heterocyclic compounds as ion channel modulators
NO3175985T3 (en) 2011-07-01 2018-04-28
CN102977054A (en) * 2012-12-12 2013-03-20 中国药科大学 Application of selective alpha2A receptor stimulant in treating alzheimer disease
SG11201509057UA (en) 2013-05-30 2015-12-30 Actelion Pharmaceuticals Ltd Cxcr7 receptor modulators
JO3316B1 (en) 2013-05-30 2019-03-13 Lilly Co Eli 3,4-dihydroisoquinolin-2(1h)-yl compounds
CN103275016B (en) * 2013-06-04 2015-03-11 温州医科大学附属第二医院 Synthetic method of 2-subsituted quinazoline compounds
BR112015031249A2 (en) 2013-06-13 2017-07-25 Veroscience Llc treatment method, method for treating a metabolic disorder or a key element thereof, method for normalizing a daily dopamine release rate in the sumn, method for stimulating dopamine release from dopaminergic neurons in an individual's sumn and pharmaceutical composition
CN103319381B (en) * 2013-06-14 2014-08-27 湖州康企药业有限公司 Preparation method of high-purity fine sulfanilamide
CN103772296B (en) * 2013-12-19 2015-06-17 安徽师范大学 Synthesis method for quinazoline derivative
EP3227263B1 (en) 2014-12-01 2019-04-10 Idorsia Pharmaceuticals Ltd Cxcr7 receptor modulators
CN105294599B (en) * 2015-09-17 2017-09-22 三峡大学 A kind of diazthines compound and its asymmetric synthetic method
CN106946920A (en) * 2017-04-05 2017-07-14 泰力特医药（湖北）有限公司 A kind of preparation method of 4 amino phenyl boronic acid derivative
WO2020253862A1 (en) * 2019-06-21 2020-12-24 上海翰森生物医药科技有限公司 Nitrogen-containing aryl phosphorus oxide derivative, preparation method therefor and use thereof
RU2726456C1 (en) * 2019-10-02 2020-07-14 Общество с ограниченной ответственностью "Научно-исследовательский институт ХимРар" (ООО "НИИ ХимРар") Hepatitis b virus (hbv) inhibitor
CN111100042B (en) * 2019-11-18 2022-05-31 苏州诚和医药化学有限公司 Preparation method of 2-methoxy-5-sulfonamide benzoic acid
CN111018750B (en) * 2019-12-19 2022-05-27 苏州诚和医药化学有限公司 Novel preparation method of 2, 3-dimethoxy-5-sulfamide benzoic acid

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL296964A (en) *
US3275625A (en) * 1966-09-27 Derivatives of
FR1217929A (en) * 1958-03-03 1960-05-06 Ciba Geigy Process for the preparation of 6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide and its salts
GB863474A (en) * 1958-08-13 1961-03-22 Knud Abildgaard Benzothiadiazine derivatives and their preparation
DE1125938B (en) * 1960-02-12 1962-03-22 Thomae Gmbh Dr K Process for the preparation of 7-sulfamyl-3, 4-dihydro-1, 2, 4-benzothiadiazine-1, 1-dioxydes
GB946864A (en) * 1960-05-06 1964-01-15 Knud Abildgaard Method for the production of 3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides
US3419552A (en) * 1961-04-12 1968-12-31 Lilly Co Eli Preparation of substituted dihydrobenzothiadiazine-1,1-dioxides
CH475269A (en) * 1962-04-19 1969-07-15 Hans Voigt Chem Pharm Fabrik D Process for the preparation of 7-sulfonamido-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxydes
US3351595A (en) * 1962-12-07 1967-11-07 Ciba Geigy Corp Derivatives of 3, 4-dihydro-2h-1, 2, 4-benzothiadiazine-1, 1-dioxide
US3311620A (en) * 1963-05-31 1967-03-28 Stanley C Bell Fused ring benzothiadiazines
US3277086A (en) * 1964-07-07 1966-10-04 American Home Prod 1, 2, 4-benzothiadiazine 1, 1-dioxides having a heterocyclic ring fused to the "b" face thereof
US4184039A (en) * 1977-12-01 1980-01-15 Paul Finkelstein Benzothiadiazine 1, 1-dioxides
AU3957093A (en) * 1992-04-15 1993-11-18 Rhone-Poulenc Rorer S.A. 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxyl ic acid derivatives, preparation thereof and drugs containing same
US5488049A (en) * 1993-12-10 1996-01-30 Fidia - Georgetown Institute For The Neuro-Sciences Method of treating learning and memory disorders using benzothiadiazide derivatives as nootropic agents
FR2722502B1 (en) * 1994-07-12 1996-08-23 Adir NOVEL BENZOTHIADIAZINE DERIVATIVE, ITS PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
NZ331549A (en) * 1996-01-29 2000-09-29 Univ California Compounds useful in treating sexual dysfunction
AU4345297A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor

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