TR200000736T2 - İkame edilmiş kroman türevleri. - Google Patents
İkame edilmiş kroman türevleri.Info
- Publication number
- TR200000736T2 TR200000736T2 TR2000/00736T TR200000736T TR200000736T2 TR 200000736 T2 TR200000736 T2 TR 200000736T2 TR 2000/00736 T TR2000/00736 T TR 2000/00736T TR 200000736 T TR200000736 T TR 200000736T TR 200000736 T2 TR200000736 T2 TR 200000736T2
- Authority
- TR
- Turkey
- Prior art keywords
- substituted
- alkyl
- derivatives
- chroma
- enantiomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Mevcut bulus; (R)-enantiyomerler, (S)-enantiyomerler veya serbest bir baz seklinde bir rasemat veya bunlarin farmasötik açidan kabul gören bir tuzu veya solvati olarak X' in N veya CH;Y' nin NR2CH2,CH2NR2,NR2CO,CONR2,NR2SO2 veya NR2CONR2, ki buradaki R2, H veya C1-C6 alkildir, R1' in H, C1-C6 alkil veya C3-C6 sikloalkil; R3' ün C1-C6 alkil, C3-C6 sikloalkil veya (CH2)n-aril, ki buradaki aril, fenil veya N,O ve S arasindan seçilen ve R4 ve/veya R5 ile mono- veya di-ikame edilebilen bir veya iki heteroatom içerikli heteroaromatik bir halkadir; ve n' nin 0 ila 4 arasinda oldugu yeni piperidil- veya piperazinil-ikame edilmis dihidro-2H-1-benzopiran türevlerinden olusan bilesiklerle, bunlarin hazirlandigi bir islemle, adi geçen terapötik açidan aktif bilesiklerin bulundugu farmasötik kompozisyonlarla ve adi geçen aktif bilesiklerin kullanimlariyla ilgilidir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703377A SE9703377D0 (sv) | 1997-09-18 | 1997-09-18 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200000736T2 true TR200000736T2 (tr) | 2000-07-21 |
Family
ID=20408297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/00736T TR200000736T2 (tr) | 1997-09-18 | 1998-09-09 | İkame edilmiş kroman türevleri. |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US6479497B1 (tr) |
| EP (1) | EP1025095B1 (tr) |
| JP (1) | JP4150161B2 (tr) |
| KR (1) | KR20010024077A (tr) |
| CN (1) | CN1278810A (tr) |
| AR (1) | AR015449A1 (tr) |
| AT (1) | ATE255098T1 (tr) |
| AU (1) | AU734580B2 (tr) |
| BR (1) | BR9812238A (tr) |
| CA (1) | CA2304037A1 (tr) |
| DE (1) | DE69820102T2 (tr) |
| EE (1) | EE200000140A (tr) |
| HR (1) | HRP20000132A2 (tr) |
| HU (1) | HUP0100684A3 (tr) |
| IL (1) | IL135073A0 (tr) |
| IS (1) | IS5402A (tr) |
| NO (1) | NO20001402L (tr) |
| PL (1) | PL339664A1 (tr) |
| SE (1) | SE9703377D0 (tr) |
| SK (1) | SK2862000A3 (tr) |
| TR (1) | TR200000736T2 (tr) |
| WO (1) | WO1999014212A1 (tr) |
| ZA (1) | ZA987813B (tr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9703377D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| AU2001288432A1 (en) | 2000-09-01 | 2002-03-22 | Icos Corporation | Materials and methods to potentiate cancer treatment |
| CA2433950A1 (en) | 2001-01-16 | 2002-07-18 | Timothy Davenport | Therapeutic chromone compounds |
| EP1353913A2 (en) | 2001-01-16 | 2003-10-22 | AstraZeneca AB | Therapeutic heterocyclic compounds |
| JP2006523681A (ja) | 2003-03-24 | 2006-10-19 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | Ｄｎａ−ｐｋ阻害剤としてのキサントン、チオキサントンおよびアクリジノン |
| ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
| US20050065099A1 (en) | 2003-09-19 | 2005-03-24 | Gail Walkinshaw | Treatment of mitochondrial diseases |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| CA2580855A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
| WO2008130319A2 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain |
| WO2008130321A2 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain |
| WO2008130322A1 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel 5-heterocyclyl-chromane derivatives for the treatment of pain |
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
| WO2008130323A1 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel 8-piperazine-tetrahydronaphtalene derivatives for the treatment of pain |
| TWI402072B (zh) | 2010-10-19 | 2013-07-21 | Lilly Co Eli | 組織蛋白酶ｓ抑制劑化合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172352B1 (en) * | 1984-06-22 | 1990-08-29 | Beecham Group Plc | Active benzopyran compounds |
| IT1190405B (it) * | 1985-10-22 | 1988-02-16 | Recordati Chem Pharm | Derivati del flavone |
| US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
| CA2047236C (en) | 1989-04-27 | 1997-07-22 | Bengt Ronny Andersson | Substituted 3-amino chromans |
| US5420151A (en) | 1989-12-22 | 1995-05-30 | Aktiebolaget Astra | Chroman derivatives |
| SE8904361D0 (sv) | 1989-12-22 | 1989-12-22 | Astra Ab | New chroman and thiochroman derivatives |
| JPH11511156A (ja) * | 1995-08-11 | 1999-09-28 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ビフェニル（チオ）アミドおよびビフェニルエタン（チオ）オン誘導体、その製造方法ならびに５−ｈｔ▲下１ｄ▼ 受容体拮抗薬としてのその使用 |
| US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| SE9703378D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| SE9703377D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| GB0112834D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| UY29892A1 (es) * | 2005-11-04 | 2007-06-29 | Astrazeneca Ab | Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones |
| UY29896A1 (es) * | 2005-11-04 | 2007-06-29 | Astrazeneca Ab | Nuevos derivados de cromano, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
-
1997
- 1997-09-18 SE SE9703377A patent/SE9703377D0/xx unknown
-
1998
- 1998-08-27 ZA ZA987813A patent/ZA987813B/xx unknown
- 1998-09-09 AU AU91932/98A patent/AU734580B2/en not_active Ceased
- 1998-09-09 DE DE69820102T patent/DE69820102T2/de not_active Expired - Fee Related
- 1998-09-09 HR HR20000132A patent/HRP20000132A2/hr not_active Application Discontinuation
- 1998-09-09 IL IL13507398A patent/IL135073A0/xx unknown
- 1998-09-09 KR KR1020007002823A patent/KR20010024077A/ko not_active Withdrawn
- 1998-09-09 US US09/171,570 patent/US6479497B1/en not_active Expired - Fee Related
- 1998-09-09 BR BR9812238-0A patent/BR9812238A/pt not_active IP Right Cessation
- 1998-09-09 CA CA002304037A patent/CA2304037A1/en not_active Abandoned
- 1998-09-09 HU HU0100684A patent/HUP0100684A3/hu unknown
- 1998-09-09 PL PL98339664A patent/PL339664A1/xx not_active Application Discontinuation
- 1998-09-09 EE EEP200000140A patent/EE200000140A/xx unknown
- 1998-09-09 WO PCT/SE1998/001603 patent/WO1999014212A1/en not_active Ceased
- 1998-09-09 TR TR2000/00736T patent/TR200000736T2/tr unknown
- 1998-09-09 SK SK286-2000A patent/SK2862000A3/sk unknown
- 1998-09-09 CN CN98811112A patent/CN1278810A/zh active Pending
- 1998-09-09 AT AT98944377T patent/ATE255098T1/de not_active IP Right Cessation
- 1998-09-09 EP EP98944377A patent/EP1025095B1/en not_active Expired - Lifetime
- 1998-09-09 JP JP2000511761A patent/JP4150161B2/ja not_active Expired - Fee Related
- 1998-09-17 AR ARP980104636A patent/AR015449A1/es not_active Application Discontinuation
-
2000
- 2000-03-14 IS IS5402A patent/IS5402A/is unknown
- 2000-03-17 NO NO20001402A patent/NO20001402L/no not_active Application Discontinuation
-
2002
- 2002-11-01 US US10/285,743 patent/US6670359B2/en not_active Expired - Fee Related
-
2003
- 2003-11-13 US US10/714,577 patent/US7056921B2/en not_active Expired - Fee Related
-
2006
- 2006-06-05 US US11/447,589 patent/US7384943B2/en not_active Expired - Fee Related
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