TR199901564T2 - Pharmaceutical dosage form that dissolves quickly and provides taste-masking. - Google Patents
Pharmaceutical dosage form that dissolves quickly and provides taste-masking.Info
- Publication number
- TR199901564T2 TR199901564T2 TR1999/01564T TR9901564T TR199901564T2 TR 199901564 T2 TR199901564 T2 TR 199901564T2 TR 1999/01564 T TR1999/01564 T TR 1999/01564T TR 9901564 T TR9901564 T TR 9901564T TR 199901564 T2 TR199901564 T2 TR 199901564T2
- Authority
- TR
- Turkey
- Prior art keywords
- dosage form
- core
- pharmaceutical dosage
- masking
- dissolves quickly
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
Hizli çözülebilen ve tat maskelendirici ispençiyari dozaj formu aktif karisim ihtiva eden çekirdek, düsük sübsitüte edilmis hidroksipiropil selülöz, ve mikrokristalin selülöz, çekirdek toplam agirliginin en az %26.0'i mikrokristalin selülözden olusan; ve çekirdek, suda çözülebilir polimer ihtiva eden çekirdek üzerinde olusturulmus iç saran tabaka; tükürükte çözülmeyen polimer ihtiva eden iç saran tabakanin üzerinde olusturulmus dis saran tabakadan olusmaktir. Böyle bir oral dozaj formu hazirlanmasini saglayan islem açiklanmistir.The core, which contains a quick dissolving and taste-masking pharmaceutical dosage form active mixture, consists of low-supposed hydroxypropyl cellulose, and microcrystalline cellulose, and at least 26.0% of the core total weight is microcrystalline cellulose; and the core, the inner-wrapping layer formed on the core containing the water-soluble polymer; It consists of an outer enveloping layer formed on the inner enveloping layer containing the insoluble polymer in saliva. The process that enables the preparation of such an oral dosage form has been described.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB9700003 | 1997-01-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199901564T2 true TR199901564T2 (en) | 1999-09-21 |
Family
ID=11004515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1999/01564T TR199901564T2 (en) | 1997-01-06 | 1997-11-20 | Pharmaceutical dosage form that dissolves quickly and provides taste-masking. |
Country Status (36)
Country | Link |
---|---|
EP (1) | EP0941075B1 (en) |
JP (1) | JP3350059B2 (en) |
KR (1) | KR20000069899A (en) |
CN (1) | CN1244119A (en) |
AP (1) | AP802A (en) |
AR (1) | AR008553A1 (en) |
AT (1) | ATE238776T1 (en) |
AU (1) | AU715867B2 (en) |
BG (1) | BG103541A (en) |
BR (1) | BR9714253A (en) |
CA (1) | CA2277017C (en) |
CO (1) | CO4650099A1 (en) |
DE (1) | DE69721559T2 (en) |
DK (1) | DK0941075T3 (en) |
EA (1) | EA199900521A1 (en) |
ES (1) | ES2192265T3 (en) |
HN (1) | HN1997000151A (en) |
HR (1) | HRP980005A2 (en) |
HU (1) | HUP0002744A3 (en) |
ID (1) | ID21806A (en) |
IL (1) | IL130582A0 (en) |
IS (1) | IS5095A (en) |
MA (1) | MA26464A1 (en) |
NO (1) | NO993315L (en) |
NZ (1) | NZ336251A (en) |
OA (1) | OA11072A (en) |
PA (1) | PA8443301A1 (en) |
PE (1) | PE27999A1 (en) |
PL (1) | PL334439A1 (en) |
SK (1) | SK89599A3 (en) |
TN (1) | TNSN98002A1 (en) |
TR (1) | TR199901564T2 (en) |
UY (1) | UY24835A1 (en) |
WO (1) | WO1998030209A1 (en) |
YU (1) | YU31599A (en) |
ZA (1) | ZA9829B (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6200591B1 (en) * | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
DE19834507A1 (en) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Pharmaceutical, water-soluble tablet formulation for the use of sildenafil |
DE19834506A1 (en) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Transmucosal therapeutic system for the use of sildenafil |
UA67802C2 (en) | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | CONTROLLED-RELEASE FORMULATIONS FOR ORAL ADMINISTRATION CONTAINING cGMP PDE-5 INHIBITOR (VARIANTS), METHOD FOR ITS PREPARATION AND METHOD FOR TREATING ERECTILE DYSFUNCTION |
EP2260836B1 (en) * | 1998-11-25 | 2016-08-10 | Cima Labs Inc. | Rapid release tablet with coated drug-containing core and surrounding taste masking layer |
FR2795962B1 (en) * | 1999-07-08 | 2003-05-09 | Prographarm Laboratoires | PROCESS FOR THE MANUFACTURE OF MASK TASTE COATED GRANULES AND IMMEDIATE RELEASE OF THE ACTIVE INGREDIENT |
NZ524572A (en) | 2000-09-06 | 2004-08-27 | Tanabe Seiyaku Co | Oral compositions comprising phosphodiesterase inhibitors ( PDE inhibitor )and an acidic substance such as fumaric acid with improved drug efficacy due to decrease solubility in neutral and alkaline regions |
GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
AR034813A1 (en) * | 2001-07-20 | 2004-03-17 | Novartis Ag | PHARMACEUTICAL COMPOSITIONS AND USE OF THE SAME |
SE0202365D0 (en) * | 2002-08-05 | 2002-08-05 | Pharmacia Ab | New formulation and use thereof |
EP1728791A4 (en) | 2004-03-25 | 2008-12-10 | Astellas Pharma Inc | Composition for solid pharmaceutical preparation of solifenacin or salt thereof |
BG66010B1 (en) * | 2004-12-08 | 2010-10-29 | "Софарма" Ад | Medicamentous form of sildenafil |
DE602006020642D1 (en) * | 2005-01-06 | 2011-04-21 | Cima Labs Inc | Taste suppressant system for non-plasticized medicines |
JPWO2007010930A1 (en) * | 2005-07-20 | 2009-01-29 | アステラス製薬株式会社 | Drug-containing coated fine particles for orally disintegrating preparation and method for producing the same |
US7815939B2 (en) | 2005-07-20 | 2010-10-19 | Astellas Pharma Inc. | Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms |
JP2007031407A (en) | 2005-07-29 | 2007-02-08 | Shin Etsu Chem Co Ltd | Coating composition containing cellulose ether with low substitution degree, and film-coated preparation with concealed unpleasant taste |
US20070098746A1 (en) * | 2005-11-02 | 2007-05-03 | Nichols William M | Multi-layered coating technology for taste masking |
JP4602949B2 (en) * | 2006-08-02 | 2010-12-22 | 和光堂株式会社 | Coated particle-containing composition and method for producing the same |
JPWO2008059881A1 (en) * | 2006-11-14 | 2010-03-04 | サンスター株式会社 | Composition for oral cavity comprising crystalline cellulose surface-treated with water-soluble substance |
JP5777273B2 (en) * | 2008-07-10 | 2015-09-09 | 大正製薬株式会社 | Formulation particles containing drug with unpleasant taste |
JP4706785B2 (en) * | 2008-09-30 | 2011-06-22 | アステラス製薬株式会社 | Particulate pharmaceutical composition for oral administration |
US20110244050A1 (en) | 2008-12-12 | 2011-10-06 | Siegfried Rhein S.A. De C.V. | Pulsed-release sildenafil composition and method for preparing said composition |
DE102009016584A1 (en) | 2009-04-06 | 2010-10-07 | Ratiopharm Gmbh | Orodispersible tablet containing a sildenafil salt |
WO2011081199A1 (en) * | 2009-12-28 | 2011-07-07 | ニプロ株式会社 | Oral preparation having improved quality |
JP5226732B2 (en) * | 2010-05-20 | 2013-07-03 | エスエス製薬株式会社 | Compression molding for hypnosis |
TWI462739B (en) * | 2010-11-02 | 2014-12-01 | Univ Kaohsiung Medical | Processes for preparing piperazinium salts of sildenafil-analogues and use thereof |
GB201119985D0 (en) * | 2011-11-19 | 2012-01-04 | Diurnal Ltd | Treatment of adrenal insufficiency |
CN103271940B (en) * | 2013-05-03 | 2014-03-12 | 湖北新济药业有限公司 | Compound metal ion replenisher and preparation method thereof |
WO2017146052A1 (en) * | 2016-02-23 | 2017-08-31 | ニプロ株式会社 | Pharmaceutical composition particles, orally disintegrating preparation including same, and method for producing pharmaceutical composition particles |
WO2020045456A1 (en) * | 2018-08-28 | 2020-03-05 | 東和薬品株式会社 | Drug-containing particle |
CN113559070B (en) * | 2021-08-18 | 2022-12-06 | 广州中冠动物药业有限公司 | Preparation method of medicine suitable for pet cough |
CN116139088B (en) * | 2023-01-31 | 2024-04-16 | 南京海纳医药科技股份有限公司 | Sildenafil citrate-containing dry suspension and preparation method thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63258809A (en) * | 1987-04-16 | 1988-10-26 | Towa Yakuhin Kk | Fine granule having excellent releasing property of medicinally active ingredient and masked bitterness |
EP0458751A1 (en) * | 1990-05-25 | 1991-11-27 | Warner-Lambert Company | Delivery system for cyclic amino acids with improved taste, texture and compressibility |
JP2576927B2 (en) * | 1992-05-15 | 1997-01-29 | ファイザー製薬株式会社 | Fine grain nucleus |
US5817338A (en) * | 1994-07-08 | 1998-10-06 | Astra Aktiebolag | Multiple unit tableted dosage form of omeprazole |
-
1997
- 1997-11-20 WO PCT/IB1997/001471 patent/WO1998030209A1/en active IP Right Grant
- 1997-11-20 DK DK97911402T patent/DK0941075T3/en active
- 1997-11-20 EA EA199900521A patent/EA199900521A1/en unknown
- 1997-11-20 CN CN97181252A patent/CN1244119A/en active Pending
- 1997-11-20 ES ES97911402T patent/ES2192265T3/en not_active Expired - Lifetime
- 1997-11-20 AT AT97911402T patent/ATE238776T1/en not_active IP Right Cessation
- 1997-11-20 YU YU31599A patent/YU31599A/en unknown
- 1997-11-20 IL IL13058297A patent/IL130582A0/en unknown
- 1997-11-20 KR KR1019997006093A patent/KR20000069899A/en not_active Application Discontinuation
- 1997-11-20 NZ NZ336251A patent/NZ336251A/en unknown
- 1997-11-20 CA CA002277017A patent/CA2277017C/en not_active Expired - Lifetime
- 1997-11-20 EP EP97911402A patent/EP0941075B1/en not_active Expired - Lifetime
- 1997-11-20 AU AU48808/97A patent/AU715867B2/en not_active Ceased
- 1997-11-20 HU HU0002744A patent/HUP0002744A3/en unknown
- 1997-11-20 PL PL97334439A patent/PL334439A1/en unknown
- 1997-11-20 TR TR1999/01564T patent/TR199901564T2/en unknown
- 1997-11-20 SK SK895-99A patent/SK89599A3/en unknown
- 1997-11-20 ID IDW990633A patent/ID21806A/en unknown
- 1997-11-20 DE DE69721559T patent/DE69721559T2/en not_active Expired - Fee Related
- 1997-11-20 JP JP53068398A patent/JP3350059B2/en not_active Expired - Fee Related
- 1997-11-20 BR BR9714253-0A patent/BR9714253A/en not_active Application Discontinuation
- 1997-11-21 HN HN1997000151A patent/HN1997000151A/en unknown
- 1997-12-18 CO CO97073877A patent/CO4650099A1/en unknown
- 1997-12-19 PA PA19978443301A patent/PA8443301A1/en unknown
- 1997-12-30 PE PE1997001188A patent/PE27999A1/en not_active Application Discontinuation
-
1998
- 1998-01-02 UY UY24835A patent/UY24835A1/en unknown
- 1998-01-05 HR HRPCT/IB97/00003A patent/HRP980005A2/en not_active Application Discontinuation
- 1998-01-05 ZA ZA9829A patent/ZA9829B/en unknown
- 1998-01-05 AR ARP980100030A patent/AR008553A1/en not_active Application Discontinuation
- 1998-01-05 MA MA24919A patent/MA26464A1/en unknown
- 1998-01-05 TN TNTNSN98002A patent/TNSN98002A1/en unknown
- 1998-01-06 AP APAP/P/1998/001173A patent/AP802A/en active
-
1999
- 1999-06-25 IS IS5095A patent/IS5095A/en unknown
- 1999-06-30 BG BG103541A patent/BG103541A/en unknown
- 1999-07-02 OA OA9900150A patent/OA11072A/en unknown
- 1999-07-05 NO NO993315A patent/NO993315L/en not_active Application Discontinuation
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