SE8803822A - - Google Patents
Info
- Publication number
- SE8803822A SE8803822A SE8803822A SE8803822A SE8803822A SE 8803822 A SE8803822 A SE 8803822A SE 8803822 A SE8803822 A SE 8803822A SE 8803822 A SE8803822 A SE 8803822A SE 8803822 A SE8803822 A SE 8803822A
- Authority
- SE
- Sweden
- Prior art keywords
- polymer
- cores
- active substance
- substance
- watersoluble
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to an oral pharmaceutical multiple units formulation comprising individual cores containing a pharmacologically active substance, said cores being provided with a coating consisting essentially of a polymer, that is insoluble in, impermeable to and non-soluble in water and in gastrointestinal fluids, and a watersoluble pore-creating substance, which is randomly distributed in said polymer, whereby said coated cores form units providing an essential zero order diffusion controlled release rate of said active substance. The invention also comprises a method of preparing these formulations.
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19888803822A SE8803822D0 (en) | 1988-10-26 | 1988-10-26 | NOVEL DOSAGE FORM |
ES89119102T ES2055775T3 (en) | 1988-10-26 | 1989-10-14 | NEW DOSAGE FORM. |
EP89119102A EP0365947B1 (en) | 1988-10-26 | 1989-10-14 | Novel dosage form |
AT89119102T ATE90556T1 (en) | 1988-10-26 | 1989-10-14 | DOSAGE FORM. |
DE89119102T DE68907177T2 (en) | 1988-10-26 | 1989-10-14 | Dosage form. |
IE334289A IE62640B1 (en) | 1988-10-26 | 1989-10-17 | Novel dosage form |
CA002000932A CA2000932C (en) | 1988-10-26 | 1989-10-18 | Oral pharmaceutical controlled release multiple unit dosage form |
IL92036A IL92036A (en) | 1988-10-26 | 1989-10-18 | Zero order diffusion controlled release multiple unit formulations |
NZ231093A NZ231093A (en) | 1988-10-26 | 1989-10-20 | Sustained-release formulation comprising units coated with an insoluble polymer containing pore-creating substances |
AU43650/89A AU612525B2 (en) | 1988-10-26 | 1989-10-24 | Novel dosage form |
PT92103A PT92103B (en) | 1988-10-26 | 1989-10-25 | PROCESS FOR THE PREPARATION OF AN ORAL PHARMACEUTICAL COMPOSITION OF MULTIPLE UNITS OF CONTROLLED LIBERATION |
FI895059A FI102455B1 (en) | 1988-10-26 | 1989-10-25 | A method of preparing an oral multi-unit pharmaceutical formulation |
PH39411A PH26653A (en) | 1988-10-26 | 1989-10-25 | Novel dosage form |
JP1276203A JPH082783B2 (en) | 1988-10-26 | 1989-10-25 | Novel dosage form |
NO894255A NO179478C (en) | 1988-10-26 | 1989-10-25 | Process for preparing multiple units with coatings containing pore forms |
HU895452A HU201883B (en) | 1988-10-26 | 1989-10-26 | Process for producing orally administerable pharmaceutical compositions consisting of composite units and having controlled release of active ingredient |
DK198905339A DK175608B1 (en) | 1988-10-26 | 1989-10-26 | New dosage form |
CN89108221A CN1043957C (en) | 1988-10-26 | 1989-10-26 | Novel dosage form |
ZA898127A ZA898127B (en) | 1988-10-26 | 1989-10-26 | Dosage form |
KR89015471A KR0120111B1 (en) | 1988-10-26 | 1989-10-26 | Novel dosage form |
US07/770,767 US5178868A (en) | 1988-10-26 | 1991-10-04 | Dosage form |
LVP-93-1388A LV10382B (en) | 1988-10-26 | 1993-12-28 | New medicinal preparation |
SG123894A SG123894G (en) | 1988-10-26 | 1994-08-25 | Novel dosage form |
HK123394A HK123394A (en) | 1988-10-26 | 1994-11-10 | Novel dosage form |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19888803822A SE8803822D0 (en) | 1988-10-26 | 1988-10-26 | NOVEL DOSAGE FORM |
SG123894A SG123894G (en) | 1988-10-26 | 1994-08-25 | Novel dosage form |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8803822A true SE8803822A (en) | 1988-10-26 |
SE8803822D0 SE8803822D0 (en) | 1988-10-26 |
Family
ID=26660328
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE19888803822A SE8803822D0 (en) | 1988-10-26 | 1988-10-26 | NOVEL DOSAGE FORM |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0365947B1 (en) |
JP (1) | JPH082783B2 (en) |
AU (1) | AU612525B2 (en) |
CA (1) | CA2000932C (en) |
DE (1) | DE68907177T2 (en) |
ES (1) | ES2055775T3 (en) |
HK (1) | HK123394A (en) |
SE (1) | SE8803822D0 (en) |
SG (1) | SG123894G (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9202250D0 (en) * | 1992-07-29 | 1992-07-29 | Gacell Lab Ab | CONTROLLED RELEASE MORPHINE PREPARATION |
US6875872B1 (en) | 1993-05-28 | 2005-04-05 | Astrazeneca | Compounds |
SE9402431D0 (en) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
BR9506018A (en) * | 1994-07-08 | 1997-09-02 | Astra Ab | Oral dosage form of multiple unit dosage in tablet processes for preparing it for inhibiting the secretion of gastric acid in mammals and in man and for the treatment of inflammatory gastrointestinal diseases in mammals and in man and transverse pressure ampoule packaging |
SE9500422D0 (en) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
SE9500478D0 (en) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
SE9600072D0 (en) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients II |
SE9600071D0 (en) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
SE9600070D0 (en) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
GB9620709D0 (en) * | 1996-10-04 | 1996-11-20 | Danbiosyst Uk | Colonic delivery of weak acid drugs |
US6066339A (en) * | 1997-10-17 | 2000-05-23 | Elan Corporation, Plc | Oral morphine multiparticulate formulation |
WO2000044353A1 (en) * | 1999-01-29 | 2000-08-03 | Losan Pharma Gmbh | Pharmaceutical compositions |
SE0001151D0 (en) * | 2000-03-31 | 2000-03-31 | Amarin Dev Ab | Method of producing a controlled-release composition |
DE10149674A1 (en) | 2001-10-09 | 2003-04-24 | Apogepha Arzneimittel Gmbh | Orally administered composition for sustained release of propiverine, useful for treatment of hypertonic bladder disorders, especially by once-daily administration |
CN1596128A (en) * | 2001-11-30 | 2005-03-16 | 辉瑞产品公司 | Pharmaceutical compositions of 5,7,14-triazatetracyclo[10.3.1.0(2,11).0(4,9)]-hexadeca-2(11)3,5,7,9-pentaene |
JP2005104914A (en) * | 2003-09-30 | 2005-04-21 | Kyowa Yakuhin Kogyo Kk | Basic agent-containing pharmaceutical preparation |
WO2007123883A2 (en) * | 2006-04-17 | 2007-11-01 | Actavis Group Ptc Ehf | Oral dosage formulations and methods of preparing the same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4160452A (en) * | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
US4557925A (en) * | 1982-07-08 | 1985-12-10 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
GB8322007D0 (en) * | 1983-08-16 | 1983-09-21 | Wellcome Found | Pharmaceutical delivery system |
JPH075457B2 (en) * | 1983-08-16 | 1995-01-25 | ザ ウエルカム フアウンデ−シヨン リミテツド | Pharmaceutical composition allowing the release of the active ingredient in a controlled manner |
DK62184D0 (en) * | 1984-02-10 | 1984-02-10 | Benzon As Alfred | DIFFUSION COATED POLYDEPOT PREPARATION |
DE3485618D1 (en) * | 1984-08-17 | 1992-04-30 | Wellcome Found | COMPOSITION FOR THE CONTROLLED DELIVERY OF AN ACTIVE SUBSTANCE AND THEIR PRODUCTION. |
SE8404467D0 (en) * | 1984-09-06 | 1984-09-06 | Ferrosan Ab | CONTROLLED-RELEASE MEDICAL PREPARATIONS |
US4728512A (en) * | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
-
1988
- 1988-10-26 SE SE19888803822A patent/SE8803822D0/en unknown
-
1989
- 1989-10-14 EP EP89119102A patent/EP0365947B1/en not_active Expired - Lifetime
- 1989-10-14 DE DE89119102T patent/DE68907177T2/en not_active Expired - Fee Related
- 1989-10-14 ES ES89119102T patent/ES2055775T3/en not_active Expired - Lifetime
- 1989-10-18 CA CA002000932A patent/CA2000932C/en not_active Expired - Fee Related
- 1989-10-24 AU AU43650/89A patent/AU612525B2/en not_active Ceased
- 1989-10-25 JP JP1276203A patent/JPH082783B2/en not_active Expired - Lifetime
-
1994
- 1994-08-25 SG SG123894A patent/SG123894G/en unknown
- 1994-11-10 HK HK123394A patent/HK123394A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2000932C (en) | 1999-12-28 |
AU4365089A (en) | 1990-05-03 |
EP0365947A1 (en) | 1990-05-02 |
SE8803822D0 (en) | 1988-10-26 |
ES2055775T3 (en) | 1994-09-01 |
DE68907177T2 (en) | 1994-01-13 |
EP0365947B1 (en) | 1993-06-16 |
HK123394A (en) | 1994-11-18 |
JPH02164821A (en) | 1990-06-25 |
JPH082783B2 (en) | 1996-01-17 |
AU612525B2 (en) | 1991-07-11 |
SG123894G (en) | 1995-03-17 |
DE68907177D1 (en) | 1993-07-22 |
CA2000932A1 (en) | 1990-04-26 |
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