TN2011000457A1 - Method or system using biomarkers for the monitoring of a treatment - Google Patents
Method or system using biomarkers for the monitoring of a treatmentInfo
- Publication number
- TN2011000457A1 TN2011000457A1 TN2011000457A TN2011000457A TN2011000457A1 TN 2011000457 A1 TN2011000457 A1 TN 2011000457A1 TN 2011000457 A TN2011000457 A TN 2011000457A TN 2011000457 A TN2011000457 A TN 2011000457A TN 2011000457 A1 TN2011000457 A1 TN 2011000457A1
- Authority
- TN
- Tunisia
- Prior art keywords
- biomarkers
- monitoring
- methyl
- treatment
- indolinone
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- CPMDPSXJELVGJG-UHFFFAOYSA-N methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate Chemical compound OC=1NC2=CC(=CC=C2C=1C(=NC1=CC=C(C=C1)N(C(CN1CCN(CC1)C)=O)C)C1=CC=CC=C1)C(=O)OC CPMDPSXJELVGJG-UHFFFAOYSA-N 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5064—Endothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09154964 | 2009-03-12 | ||
| PCT/EP2010/053063 WO2010103058A1 (en) | 2009-03-12 | 2010-03-11 | Method or system using biomarkers for the monitoring of a treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2011000457A1 true TN2011000457A1 (en) | 2013-03-27 |
Family
ID=42129920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TN2011000457A TN2011000457A1 (en) | 2009-03-12 | 2011-09-09 | Method or system using biomarkers for the monitoring of a treatment |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8802384B2 (enExample) |
| EP (1) | EP2406628A1 (enExample) |
| JP (1) | JP5667581B2 (enExample) |
| KR (1) | KR20110137307A (enExample) |
| CN (1) | CN102334030A (enExample) |
| AR (1) | AR076113A1 (enExample) |
| AU (1) | AU2010223256B2 (enExample) |
| BR (1) | BRPI1011688A2 (enExample) |
| CA (1) | CA2755055A1 (enExample) |
| CL (1) | CL2011002260A1 (enExample) |
| CO (1) | CO6430497A2 (enExample) |
| EA (1) | EA201101300A1 (enExample) |
| EC (1) | ECSP11011323A (enExample) |
| IL (1) | IL214747A0 (enExample) |
| MA (1) | MA33120B1 (enExample) |
| MX (1) | MX2011009482A (enExample) |
| NZ (1) | NZ594843A (enExample) |
| PE (1) | PE20120592A1 (enExample) |
| SG (1) | SG174324A1 (enExample) |
| TN (1) | TN2011000457A1 (enExample) |
| TW (1) | TW201100802A (enExample) |
| UA (1) | UA107789C2 (enExample) |
| UY (1) | UY32482A (enExample) |
| WO (1) | WO2010103058A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| UA107560C2 (uk) * | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| NO2299987T3 (enExample) * | 2008-06-06 | 2018-07-21 | ||
| US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
| CN104003925B (zh) * | 2013-06-05 | 2016-03-30 | 四川大学 | 吲哚酮化合物或其衍生物及其用途 |
| US20150044288A1 (en) | 2013-07-31 | 2015-02-12 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| WO2018081236A1 (en) * | 2016-10-28 | 2018-05-03 | Cedars-Sinai Medical Center | Method of predicting progression of idiopathic pulmonary fibrosis and monitoring of therapeutic efficacy |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6762180B1 (en) * | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| DE10237423A1 (de) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| EP1571225A1 (en) | 2004-03-02 | 2005-09-07 | PrimaGen Holding B.V. | Diagnosis of a disease and monitoring of therapy using the AC133 gene |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1777523A1 (en) | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| EP2008103B1 (en) | 2006-04-18 | 2010-07-28 | Wellstat Biologics Corporation | Detection of circulating endothelial cells |
| EP1870400A1 (en) | 2006-06-08 | 2007-12-26 | Boehringer Ingelheim Pharma GmbH & Co. KG | Salts and crystalline salt forms of an 2-indolinone derivative |
| CN101512017A (zh) * | 2006-09-07 | 2009-08-19 | 阿斯利康(瑞典)有限公司 | 评价用靶向ret受体酪氨酸激酶的药物治疗的患者的方法 |
| EP2527467A3 (en) | 2007-04-13 | 2013-03-20 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators |
| US20100184049A1 (en) | 2007-04-27 | 2010-07-22 | Steve Goodison | Glycoprotein Profiling of Bladder Cancer |
-
2010
- 2010-03-09 US US12/720,663 patent/US8802384B2/en not_active Expired - Fee Related
- 2010-03-10 UY UY0001032482A patent/UY32482A/es not_active Application Discontinuation
- 2010-03-11 CN CN201080009568XA patent/CN102334030A/zh active Pending
- 2010-03-11 JP JP2011553450A patent/JP5667581B2/ja not_active Expired - Fee Related
- 2010-03-11 KR KR1020117021089A patent/KR20110137307A/ko not_active Withdrawn
- 2010-03-11 BR BRPI1011688A patent/BRPI1011688A2/pt not_active IP Right Cessation
- 2010-03-11 NZ NZ594843A patent/NZ594843A/en not_active IP Right Cessation
- 2010-03-11 CA CA2755055A patent/CA2755055A1/en not_active Abandoned
- 2010-03-11 EP EP10709198A patent/EP2406628A1/en not_active Withdrawn
- 2010-03-11 SG SG2011065224A patent/SG174324A1/en unknown
- 2010-03-11 AU AU2010223256A patent/AU2010223256B2/en not_active Ceased
- 2010-03-11 MX MX2011009482A patent/MX2011009482A/es active IP Right Grant
- 2010-03-11 PE PE2011001619A patent/PE20120592A1/es not_active Application Discontinuation
- 2010-03-11 TW TW099107108A patent/TW201100802A/zh unknown
- 2010-03-11 WO PCT/EP2010/053063 patent/WO2010103058A1/en not_active Ceased
- 2010-03-11 EA EA201101300A patent/EA201101300A1/ru unknown
- 2010-03-11 AR ARP100100765A patent/AR076113A1/es unknown
- 2010-03-11 MA MA34165A patent/MA33120B1/fr unknown
- 2010-11-03 UA UAA201111801A patent/UA107789C2/ru unknown
-
2011
- 2011-08-18 IL IL214747A patent/IL214747A0/en unknown
- 2011-09-09 TN TN2011000457A patent/TN2011000457A1/fr unknown
- 2011-09-12 CO CO11117849A patent/CO6430497A2/es not_active Application Discontinuation
- 2011-09-12 CL CL2011002260A patent/CL2011002260A1/es unknown
- 2011-09-13 EC EC2011011323A patent/ECSP11011323A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20120592A1 (es) | 2012-06-09 |
| AR076113A1 (es) | 2011-05-18 |
| JP5667581B2 (ja) | 2015-02-12 |
| NZ594843A (en) | 2014-03-28 |
| UY32482A (es) | 2010-10-29 |
| EP2406628A1 (en) | 2012-01-18 |
| BRPI1011688A2 (pt) | 2016-03-22 |
| AU2010223256B2 (en) | 2014-08-21 |
| JP2012520446A (ja) | 2012-09-06 |
| ECSP11011323A (es) | 2011-10-31 |
| MA33120B1 (fr) | 2012-03-01 |
| WO2010103058A1 (en) | 2010-09-16 |
| CO6430497A2 (es) | 2012-04-30 |
| IL214747A0 (en) | 2011-11-30 |
| MX2011009482A (es) | 2011-09-27 |
| SG174324A1 (en) | 2011-10-28 |
| AU2010223256A1 (en) | 2011-09-15 |
| TW201100802A (en) | 2011-01-01 |
| CL2011002260A1 (es) | 2012-03-23 |
| CN102334030A (zh) | 2012-01-25 |
| US8802384B2 (en) | 2014-08-12 |
| US20100233705A1 (en) | 2010-09-16 |
| KR20110137307A (ko) | 2011-12-22 |
| CA2755055A1 (en) | 2010-09-16 |
| EA201101300A1 (ru) | 2012-04-30 |
| UA107789C2 (en) | 2015-02-25 |
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