CA2755055A1 - Method or system using biomarkers for the monitoring of a treatment - Google Patents

Method or system using biomarkers for the monitoring of a treatment Download PDF

Info

Publication number
CA2755055A1
CA2755055A1 CA2755055A CA2755055A CA2755055A1 CA 2755055 A1 CA2755055 A1 CA 2755055A1 CA 2755055 A CA2755055 A CA 2755055A CA 2755055 A CA2755055 A CA 2755055A CA 2755055 A1 CA2755055 A1 CA 2755055A1
Authority
CA
Canada
Prior art keywords
cells
treatment
monitoring
accordance
biomarker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2755055A
Other languages
English (en)
French (fr)
Inventor
Tokuzo Arao
Kanae Kudo
Kazuhiko Nakagawa
Kazuto Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42129920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2755055(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CA2755055A1 publication Critical patent/CA2755055A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064Endothelial cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2755055A 2009-03-12 2010-03-11 Method or system using biomarkers for the monitoring of a treatment Abandoned CA2755055A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09154964 2009-03-12
EP09154964.2 2009-03-12
PCT/EP2010/053063 WO2010103058A1 (en) 2009-03-12 2010-03-11 Method or system using biomarkers for the monitoring of a treatment

Publications (1)

Publication Number Publication Date
CA2755055A1 true CA2755055A1 (en) 2010-09-16

Family

ID=42129920

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2755055A Abandoned CA2755055A1 (en) 2009-03-12 2010-03-11 Method or system using biomarkers for the monitoring of a treatment

Country Status (24)

Country Link
US (1) US8802384B2 (enExample)
EP (1) EP2406628A1 (enExample)
JP (1) JP5667581B2 (enExample)
KR (1) KR20110137307A (enExample)
CN (1) CN102334030A (enExample)
AR (1) AR076113A1 (enExample)
AU (1) AU2010223256B2 (enExample)
BR (1) BRPI1011688A2 (enExample)
CA (1) CA2755055A1 (enExample)
CL (1) CL2011002260A1 (enExample)
CO (1) CO6430497A2 (enExample)
EA (1) EA201101300A1 (enExample)
EC (1) ECSP11011323A (enExample)
IL (1) IL214747A0 (enExample)
MA (1) MA33120B1 (enExample)
MX (1) MX2011009482A (enExample)
NZ (1) NZ594843A (enExample)
PE (1) PE20120592A1 (enExample)
SG (1) SG174324A1 (enExample)
TN (1) TN2011000457A1 (enExample)
TW (1) TW201100802A (enExample)
UA (1) UA107789C2 (enExample)
UY (1) UY32482A (enExample)
WO (1) WO2010103058A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2299987B1 (en) 2008-06-06 2018-02-21 Boehringer Ingelheim International GmbH Capsule pharmaceutical dosage form comprising a suspension formulation of an indolinone derivative
UA107560C2 (uk) * 2008-06-06 2015-01-26 Фармацевтична лікарська форма для негайного вивільнення похідної індолінону
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
US20140350022A1 (en) 2013-05-10 2014-11-27 Boehringer Ingelheim International Gmbh Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment
CN104003925B (zh) * 2013-06-05 2016-03-30 四川大学 吲哚酮化合物或其衍生物及其用途
JP6799201B2 (ja) 2013-07-31 2020-12-16 アヴァリン ファーマ インク. エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用
WO2018081236A1 (en) * 2016-10-28 2018-05-03 Cedars-Sinai Medical Center Method of predicting progression of idiopathic pulmonary fibrosis and monitoring of therapeutic efficacy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA75054C2 (uk) 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
US6762180B1 (en) * 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
DE10237423A1 (de) 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
US20040204458A1 (en) * 2002-08-16 2004-10-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of Lck inhibitors for treatment of immunologic diseases
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
EP1571225A1 (en) 2004-03-02 2005-09-07 PrimaGen Holding B.V. Diagnosis of a disease and monitoring of therapy using the AC133 gene
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
MX2008013333A (es) 2006-04-18 2008-11-10 Wellstat Biologics Corp Deteccion de celulas endoteliales circulantes.
EP1870400A1 (en) * 2006-06-08 2007-12-26 Boehringer Ingelheim Pharma GmbH & Co. KG Salts and crystalline salt forms of an 2-indolinone derivative
KR20090048644A (ko) * 2006-09-07 2009-05-14 아스트라제네카 아베 Ret 수용체 티로신 키나아제를 타겟으로 하는 약물 치료를 위한 환자 평가 방법
WO2008128008A2 (en) 2007-04-13 2008-10-23 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
US20100184049A1 (en) 2007-04-27 2010-07-22 Steve Goodison Glycoprotein Profiling of Bladder Cancer

Also Published As

Publication number Publication date
US20100233705A1 (en) 2010-09-16
JP5667581B2 (ja) 2015-02-12
JP2012520446A (ja) 2012-09-06
UA107789C2 (en) 2015-02-25
MA33120B1 (fr) 2012-03-01
KR20110137307A (ko) 2011-12-22
CO6430497A2 (es) 2012-04-30
CL2011002260A1 (es) 2012-03-23
WO2010103058A1 (en) 2010-09-16
UY32482A (es) 2010-10-29
AU2010223256B2 (en) 2014-08-21
PE20120592A1 (es) 2012-06-09
MX2011009482A (es) 2011-09-27
TN2011000457A1 (en) 2013-03-27
ECSP11011323A (es) 2011-10-31
BRPI1011688A2 (pt) 2016-03-22
US8802384B2 (en) 2014-08-12
AR076113A1 (es) 2011-05-18
CN102334030A (zh) 2012-01-25
NZ594843A (en) 2014-03-28
EP2406628A1 (en) 2012-01-18
EA201101300A1 (ru) 2012-04-30
SG174324A1 (en) 2011-10-28
TW201100802A (en) 2011-01-01
AU2010223256A1 (en) 2011-09-15
IL214747A0 (en) 2011-11-30

Similar Documents

Publication Publication Date Title
Mastelic-Gavillet et al. Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
AU2010223256B2 (en) Method or system using biomarkers for the monitoring of a treatment
JP5795311B2 (ja) 抗体ベースのアレイを使用する胃癌療法のための薬物選択
KR101553723B1 (ko) 항체­기반 어레이를 사용한 폐 암 치료를 위한 약물 선별법
CA2716826C (en) Drug selection for breast cancer therapy using antibody-based arrays
RU2558797C2 (ru) Способы выявления онкогенных слитых белков, основанные на анализе близкого взаимного расположения
Fan et al. Interleukin‐1β augments the angiogenesis of endothelial progenitor cells in an NF‐κB/CXCR7‐dependent manner
Gotesman et al. mTOR inhibition enhances efficacy of dasatinib in ABL-rearranged Ph-like B-ALL
Chen et al. Tumor-derived exosomal ICAM1 promotes bone metastasis of triple-negative breast cancer by inducing CD8+ T cell exhaustion
WO2021075528A1 (ja) 薬物毒性評価方法
Greenfield et al. Surrogate markers predict angiogenic potential and survival in patients with glioblastoma multiforme
CN111971557A (zh) 嗜中性粒细胞亚型
Kim et al. Prediction of tumor metastasis via extracellular vesicles-treated platelet adhesion on a blood vessel chip
JP7255896B2 (ja) シクロホスファミド療法に対する応答者の予測
Comin-Anduix et al. Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma
CN113747919A (zh) 评估由放射治疗获得的抗肿瘤免疫效果的外周血生物标志物
Chen et al. Construction of IMMS containing multi-site liposomes for dynamic monitoring of blood CTC in patients with osimertinib-resistant non-small-cell lung cancer and its mechanism
HK1162668A (en) Method or system using biomarkers for the monitoring of a treatment
WO2025012911A1 (en) Methods for determining personalized treatment and uses thereof for treating disorders
TW202603361A (zh) 胰臟癌患者之il—6抑制劑與化學療法之併用療法之治療效果預測法
Maria et al. Platelet-derived growth factor and platelet-derived growth factor receptor-α expression in the normal human thymus and...
Fung The effect of molecular targeted agents used in combination with chemotherapy to inhibit the repopulation of tumour cells and xenografts
Dakhil Eicosapentaenoic acid: the answers are not all in
Thomas et al. 489 LC06, a novel angiopoietin-2 selective human antibody with potent anti-tumoral and anti-angiogenic efficacy in different xenograft models
Abrantes et al. 573 Does GLUTs expression influence 18F-FDG uptake? Study in breast cancer cell lines

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20160311