TH95082A - วิธีการสำหรับการผลิตกรดแอล-อะมิโนโดยใช้แบคทีเรียของตระกูล Enterobacteriaceae - Google Patents
วิธีการสำหรับการผลิตกรดแอล-อะมิโนโดยใช้แบคทีเรียของตระกูล EnterobacteriaceaeInfo
- Publication number
- TH95082A TH95082A TH701003581A TH0701003581A TH95082A TH 95082 A TH95082 A TH 95082A TH 701003581 A TH701003581 A TH 701003581A TH 0701003581 A TH0701003581 A TH 0701003581A TH 95082 A TH95082 A TH 95082A
- Authority
- TH
- Thailand
- Prior art keywords
- series
- amino acid
- alcohol dehydrogenase
- glutamic acid
- replacement
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title claims abstract 9
- 150000008575 L-amino acids Chemical class 0.000 title claims abstract 8
- 241000588921 Enterobacteriaceae Species 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 238000000034 method Methods 0.000 claims abstract 19
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims abstract 15
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims abstract 15
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract 13
- 229960002989 glutamic acid Drugs 0.000 claims abstract 9
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims abstract 6
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 4
- 239000001301 oxygen Substances 0.000 claims abstract 4
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 claims abstract 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims abstract 3
- 229930064664 L-arginine Natural products 0.000 claims abstract 3
- 235000014852 L-arginine Nutrition 0.000 claims abstract 3
- 239000004473 Threonine Substances 0.000 claims abstract 3
- 229960002898 threonine Drugs 0.000 claims abstract 3
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- 229940024606 amino acid Drugs 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 12
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 6
- 235000013922 glutamic acid Nutrition 0.000 claims 6
- 239000004220 glutamic acid Substances 0.000 claims 6
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 5
- 150000003679 valine derivatives Chemical class 0.000 claims 5
- 150000001294 alanine derivatives Chemical group 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
- 241000607142 Salmonella Species 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 3
- 239000012190 activator Substances 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 150000002519 isoleucine derivatives Chemical group 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 241000588698 Erwinia Species 0.000 claims 2
- 241000588722 Escherichia Species 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 241000588748 Klebsiella Species 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- 240000006024 Lactobacillus plantarum Species 0.000 claims 2
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 2
- 241000588771 Morganella <proteobacterium> Species 0.000 claims 2
- 241000520272 Pantoea Species 0.000 claims 2
- 241000588696 Pantoea ananatis Species 0.000 claims 2
- 241000588701 Pectobacterium carotovorum Species 0.000 claims 2
- 241000588768 Providencia Species 0.000 claims 2
- 241000607720 Serratia Species 0.000 claims 2
- 241000607768 Shigella Species 0.000 claims 2
- 241000607762 Shigella flexneri Species 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 238000009360 aquaculture Methods 0.000 claims 2
- 244000144974 aquaculture Species 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 claims 2
- 150000002333 glycines Chemical class 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 229960002885 histidine Drugs 0.000 claims 2
- 229940072205 lactobacillus plantarum Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 150000002742 methionines Chemical class 0.000 claims 2
- 229960005190 phenylalanine Drugs 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 108010068370 Glutens Proteins 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical group CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- -1 L-sysine Chemical compound 0.000 claims 1
- 241000194035 Lactococcus lactis Species 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 241001024304 Mino Species 0.000 claims 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- 235000021312 gluten Nutrition 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 235000018977 lysine Nutrition 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 125000003607 serino group Chemical class [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 235000020046 sherry Nutrition 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
- 101150014383 adhE gene Proteins 0.000 abstract 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 abstract 1
Abstract
DC60 (15/10/50) การประดิษฐ์นี้ได้เปิดเผยถึงวิธีการสำหรับการผลิตกรดแอล-อะมิโนถูกอธิบายไว้, ตัวอย่างเช่น แอล-ทรีโอนีน, แอล-ไลซีน, แอล-ฮิสติดีน, แอล-เฟนิลอะลานีน, แอล-อาร์จินีน, แอล-ทริปโตแฟน, กรด แอล-กลูตามิกโดยใช้แบคทีเรียของตระกูล Enterobacteriaceae, โดยที่แบคทีเรียดังกล่าวได้ถูกดัดแปลง เพื่อที่ให้มีการเด่นขึ้นของการทำหน้าที่ของแอลกอฮอล์ดีไฮโดรจีเนสชนิดดั้งเดิมที่ถูกถอดรหัสโดยยีน adhE หรือ แอลกอฮอล์ดีไฮโดรจีเนสกลายพันธุ์ที่ซึ่งทนทานการไม่มีการทำหน้าที่ที่มีออกซิเจน
Claims (1)
1. วิธีการตามข้อใดข้อหนึ่งของข้อถือสิทธิข้อ 1ถึง 10, โดยที่แอล-อะมิโนดังกล่าวถูก เลือกจากกลุ่มที่ประกอบด้วยแอล-ทรีโอนีน, แอล-ไลซีน, แอล-ฮิสติดีน, แอล-เฟนิลอะลานีน, แอล- อาร์จินีน, แอล-ทริปโตแฟน, กรดแอล-กลูตามิก, และ แอล-ลูซีน แอล-กลูตามิก
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH95082B TH95082B (th) | 2009-04-09 |
| TH95082A true TH95082A (th) | 2009-04-09 |
| TH73041B TH73041B (th) | 2019-12-06 |
Family
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116018400A (zh) * | 2020-06-26 | 2023-04-25 | 瓦克化学股份公司 | 改进的产生半胱氨酸的菌株 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116018400A (zh) * | 2020-06-26 | 2023-04-25 | 瓦克化学股份公司 | 改进的产生半胱氨酸的菌株 |
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