TH95055A - Hydroxyamide is a histone inhibitor. De-acetylase and pharmaceutical mixtures that contain it - Google Patents
Hydroxyamide is a histone inhibitor. De-acetylase and pharmaceutical mixtures that contain itInfo
- Publication number
- TH95055A TH95055A TH601001032A TH0601001032A TH95055A TH 95055 A TH95055 A TH 95055A TH 601001032 A TH601001032 A TH 601001032A TH 0601001032 A TH0601001032 A TH 0601001032A TH 95055 A TH95055 A TH 95055A
- Authority
- TH
- Thailand
- Prior art keywords
- aromatic
- histone
- inhibitor
- acetylase
- hydroxyamide
- Prior art date
Links
- 108010033040 Histones Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- ZXKINMCYCKHYFR-UHFFFAOYSA-N aminooxidanide Chemical compound [O-]N ZXKINMCYCKHYFR-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 abstract 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000002738 chelating agent Substances 0.000 abstract 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 239000011701 zinc Substances 0.000 abstract 2
- 229910052725 zinc Inorganic materials 0.000 abstract 2
- 229910002056 binary alloy Inorganic materials 0.000 abstract 1
Abstract
DC60 (06/06/49) สารประกอบที่มีแอคติวิตี้เป็นตัวยับยั้งฮิสโตน ดีอะซีทิเลส (HDAC) ถูกอธิบาย สารประกอบถูกศึกษาลักษณะทางเคมีโดยมีกรดไฮดรอกชามิค, ที่มีสังกะสีเป็นคีเลเตอร์, และ นิวเคลียสของอะโรมาติคถูกเชื่อมด้วยตัวเชื่อมซึ่งในระบบไบไซคลิค อะโรมาติคหรือไม่ก็วงแหวน ไพเพอริดิโนปรากฏ สารประกอบที่มีแอคติวิตี้เป็นตัวยับยั้งฮิสโตน ดีอะชีทิเลส (HDAC) ถูกอธิบาย สารประกอบถูกศึกษาลักษณะทางเคมีโดยมีกรดไฮดรอกชามิค, ที่มีสังกะสีเป็นคีเลเตอร์, และ นิวเคลียสของอะโรมาติคถูกเชื่อมด้วยตัวเชื่อมซึ่งในระบบไบไซคลิค อะโรมาติคหรือไม่ก็วงแหวน ไพเพอริดิโนปรากฎ สิทธิบัตรยา DC60 (06/06/49) An active compound as a histone diazetylase (HDAC) inhibitor was described.The compound was chemically studied with hydroxychamic acid, containing zinc. Is a chelator, and the aromatic nucleus is bridged by a coupler, which in the binary system Aromatic or ring Piperidino appears The active compound as an inhibitor of histone deacthylase (HDAC) is described. Compounds are chemically studied with hydroxychamic acid, with zinc as chelator, and the nucleus of Aromatic is welded by a coupler, in which the binary Aromatic or ring Piperidino appears patent for drug
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH95055B TH95055B (en) | 2009-04-09 |
| TH95055A true TH95055A (en) | 2009-04-09 |
Family
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