TH66056A - Sulfonyl amino derivatives, a new histone diazetylase inhibitor. - Google Patents
Sulfonyl amino derivatives, a new histone diazetylase inhibitor.Info
- Publication number
- TH66056A TH66056A TH301000863A TH0301000863A TH66056A TH 66056 A TH66056 A TH 66056A TH 301000863 A TH301000863 A TH 301000863A TH 0301000863 A TH0301000863 A TH 0301000863A TH 66056 A TH66056 A TH 66056A
- Authority
- TH
- Thailand
- Prior art keywords
- diazetylase
- inhibitor
- formula
- sulfonyl amino
- amino derivatives
- Prior art date
Links
- 108010033040 Histones Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 3
- 229940079593 drug Drugs 0.000 claims abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000003964 Histone deacetylase Human genes 0.000 abstract 1
- 108090000353 Histone deacetylase Proteins 0.000 abstract 1
Abstract
DC60 (09/06/46) การประดิษฐ์นี้ประกอบรวมด้วยสารประกอบใหม่ของสูตร (I) (สูตรทางเคมี) (I) โดยที่ n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z และ ---- A มีความหมายตามที่นิยาม ซึ่งมี กิจกรรมทางเอนไซม์ที่ยับยั้งฮิสโทนดีอะซีทิเลส การเตรียมของมัน สารผสมที่มีมันและการใช้มัน เป็นยา การประดิษฐ์นี้ประกอบรวมด้วยสารประกอบใหม่ของสูตร (I) (สูตรทางเคมี) (I) โดยที่ n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z และ (สูตร) มีความหมายตามที่นิยาม ซึ่งมี กิจกรรมทางเอนไซม์ที่ยับยั้งฮิสโทนดีอะซีทิเลส การเตรียมของมัน สารผสมที่มีมันและการใช้มัน เป็นยา สิทธิบัตรยา DC60 (09/06/46) This invention includes a new compound of formula (I) (chemical formula) (I), where n, m, t, R1, R2, R3, R4, R5, L, Q. , X, Y, Z, and ---- A, as defined by the definition, have enzymatic activity that inhibits histone deacetylase. Preparation of it Oily mixtures and their use as drugs.This invention included a new compound of formula (I) (chemical formula) (I), where n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and (formula) mean, as defined, have enzymatic activity that inhibits histone diazetylase. Preparation of it Mixture with oily and its use as a patent drug
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH66056A true TH66056A (en) | 2005-01-04 |
Family
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