TH77233B - Lactam-containing compounds and their derivatives are inhibitors of factor Xa. - Google Patents
Lactam-containing compounds and their derivatives are inhibitors of factor Xa.Info
- Publication number
- TH77233B TH77233B TH201003138A TH0201003138A TH77233B TH 77233 B TH77233 B TH 77233B TH 201003138 A TH201003138 A TH 201003138A TH 0201003138 A TH0201003138 A TH 0201003138A TH 77233 B TH77233 B TH 77233B
- Authority
- TH
- Thailand
- Prior art keywords
- derivatives
- containing compounds
- lactam
- factor
- inhibitors
- Prior art date
Links
- 108010074860 Factor Xa Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000003951 lactams Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- HRGUSFBJBOKSML-UHFFFAOYSA-N 3',5'-di-O-methyltricetin Chemical compound COC1=C(O)C(OC)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 HRGUSFBJBOKSML-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- IDDMFNIRSJVBHE-UHFFFAOYSA-N Piscigenin Natural products COC1=C(O)C(OC)=CC(C=2C(C3=C(O)C=C(O)C=C3OC=2)=O)=C1 IDDMFNIRSJVBHE-UHFFFAOYSA-N 0.000 abstract 1
- 229940122055 Serine protease inhibitor Drugs 0.000 abstract 1
- 101710102218 Serine protease inhibitor Proteins 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000003001 serine protease inhibitor Substances 0.000 abstract 1
- BMCJATLPEJCACU-UHFFFAOYSA-N tricin Natural products COc1cc(OC)c(O)c(c1)C2=CC(=O)c3c(O)cc(O)cc3O2 BMCJATLPEJCACU-UHFFFAOYSA-N 0.000 abstract 1
Abstract
DC60 (07/10/45) การประยุกต์ใช้นี้อธิบายสารประกอบที่มีแลคแตมและอนุพันธ์ของสิ่งเหล่านี้ของสูตร I P4-P-M-M4 I หรือรูปแบบเกลือที่สามารถยอมรับได้ทางเภสัชกรรมของสิ่ง เหล่านี้, โดยที่วงแหวน P, ถ้าปรากฏคือคาร์บอไซเคิลหรือเฮต เทอโรไซเคิลที่มีคาร์บอน 5-7 และวงแหวน M คือคาร์บอไซเคิล หรือ เฮตเทอโรไซเคิลหรือที่มีคาร์บอน 5-7 สารประกอบของการ ประดิษฐ์นี้ใช้ประโยชน์เป็นตัวยับยั้งเซอรีน โปรตีเอสที่ คล้ายกับทริบซิน, โดยเฉพาะอย่างยิ่งปัจจัย Xa: สิทธิบัตรยา DC60 (07/10/45) This application describes lactam-containing compounds and their derivatives of formula I P4-PM-M4 I or the pharmaceutically acceptable salt form of them, where the P ring, if present is carbocycle or het. Terocycles with 5-7 carbon and M ring are carbocycles or heterocycles or with 5-7 carbons. This invention is exploited as a serine protease inhibitor similar to tricin, particularly factor Xa: patent drug.
Claims (1)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH0201003138B TH0201003138B (en) | 2015-10-12 |
| TH143475A TH143475A (en) | 2015-10-12 |
| TH77233B true TH77233B (en) | 2020-07-13 |
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