NO20073758L - 2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidines used as CGRP antagonists - Google Patents
2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidines used as CGRP antagonistsInfo
- Publication number
- NO20073758L NO20073758L NO20073758A NO20073758A NO20073758L NO 20073758 L NO20073758 L NO 20073758L NO 20073758 A NO20073758 A NO 20073758A NO 20073758 A NO20073758 A NO 20073758A NO 20073758 L NO20073758 L NO 20073758L
- Authority
- NO
- Norway
- Prior art keywords
- benzodiazepin
- tetrahydro
- oxo
- cgrp antagonists
- salts
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A61P39/00—General protective or antinoxious agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
Abstract
Det beskrives nye CGRP-antagonister med den generelle Formel (I) hvor B, R1 og R2 er som definert i krav 1, deres tautomerer, deres isomerer, deres diastereomerer, deres enantiomerer, deres hydrater, deres blandinger og deres salter, samt hydratene av saltene, særlig deres fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, medikamenter inneholdende disse forbindelsene, deres anvendelse og fremgangsmåte for deres fremstilling. ?? ?? ?? ?? 1New CGRP antagonists of general Formula (I) are disclosed wherein B, R1 and R2 are as defined in claim 1, their tautomers, their isomers, their diastereomers, their enantiomers, their hydrates, their mixtures and their salts, as well as the hydrates of the salts, especially their physiologically acceptable salts with inorganic or organic acids or bases, drugs containing these compounds, their use and process for their preparation. ?? ?? ?? ?? 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2005/003094 WO2005092880A1 (en) | 2004-03-29 | 2005-03-23 | Selected cgrp antagonists, methods for the production thereof and their use as medicaments |
PCT/EP2006/002557 WO2006100026A1 (en) | 2005-03-23 | 2006-03-21 | 2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidines used as cgrp antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20073758L true NO20073758L (en) | 2007-10-19 |
Family
ID=36406232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20073758A NO20073758L (en) | 2005-03-23 | 2007-07-19 | 2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidines used as CGRP antagonists |
Country Status (19)
Country | Link |
---|---|
EP (2) | EP1992349B8 (en) |
JP (1) | JP4210322B2 (en) |
KR (1) | KR20070113317A (en) |
CN (2) | CN101146799A (en) |
AU (1) | AU2006226544A1 (en) |
CA (1) | CA2600189A1 (en) |
DE (1) | DE502006002066D1 (en) |
DK (1) | DK1863791T5 (en) |
EA (1) | EA012590B1 (en) |
ES (1) | ES2317512T3 (en) |
HR (1) | HRP20090011T3 (en) |
MY (1) | MY144635A (en) |
NO (1) | NO20073758L (en) |
PL (1) | PL1863791T3 (en) |
PT (1) | PT1863791E (en) |
RS (1) | RS50722B (en) |
SI (1) | SI1863791T1 (en) |
WO (1) | WO2006100026A1 (en) |
ZA (1) | ZA200705852B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10250082A1 (en) | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals |
DE102004015723A1 (en) * | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals |
US7696195B2 (en) | 2004-04-22 | 2010-04-13 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
EP1770086A1 (en) * | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Selected CGRP antagonists, process for their preparation as well as their use as medicaments |
PE20080153A1 (en) * | 2006-06-08 | 2008-04-14 | Boehringer Ingelheim Int | PHARMACEUTICAL COMPOSITION INCLUDING AN ANTAGONIST OF THE PEPTIDE RELATED TO THE CALCITONIN GENE (CGRP) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10250082A1 (en) * | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals |
DE10250080A1 (en) * | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals |
EP1644332A1 (en) | 2003-07-03 | 2006-04-12 | Poseidon Pharmaceuticals A/S | Diarylmethyl derivatives as potassium channel modulators |
TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
EP1619187A1 (en) | 2004-07-23 | 2006-01-25 | Boehringer Ingelheim Pharma GmbH & Co. KG | Process for the preparation of 3-(4-piperidinyl)- 2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-on |
-
2006
- 2006-03-18 CN CNA2006800095861A patent/CN101146799A/en active Pending
- 2006-03-21 AU AU2006226544A patent/AU2006226544A1/en not_active Abandoned
- 2006-03-21 SI SI200630191T patent/SI1863791T1/en unknown
- 2006-03-21 PL PL06723571T patent/PL1863791T3/en unknown
- 2006-03-21 PT PT06723571T patent/PT1863791E/en unknown
- 2006-03-21 CA CA002600189A patent/CA2600189A1/en not_active Abandoned
- 2006-03-21 DE DE502006002066T patent/DE502006002066D1/en active Active
- 2006-03-21 EP EP08160848.1A patent/EP1992349B8/en active Active
- 2006-03-21 WO PCT/EP2006/002557 patent/WO2006100026A1/en active Application Filing
- 2006-03-21 KR KR1020077024261A patent/KR20070113317A/en not_active Application Discontinuation
- 2006-03-21 EP EP06723571A patent/EP1863791B1/en active Active
- 2006-03-21 JP JP2008501243A patent/JP4210322B2/en active Active
- 2006-03-21 ES ES06723571A patent/ES2317512T3/en active Active
- 2006-03-21 CN CNA2006800095984A patent/CN101146790A/en active Pending
- 2006-03-21 DK DK06723571.3T patent/DK1863791T5/en active
- 2006-03-21 EA EA200701843A patent/EA012590B1/en not_active IP Right Cessation
- 2006-03-21 RS RSP-2009/0019A patent/RS50722B/en unknown
- 2006-03-23 MY MYPI20061292A patent/MY144635A/en unknown
-
2007
- 2007-07-16 ZA ZA200705852A patent/ZA200705852B/en unknown
- 2007-07-19 NO NO20073758A patent/NO20073758L/en not_active Application Discontinuation
-
2009
- 2009-01-12 HR HR20090011T patent/HRP20090011T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2006226544A1 (en) | 2006-09-28 |
CA2600189A1 (en) | 2006-09-28 |
EP1992349B1 (en) | 2013-07-31 |
EP1863791B1 (en) | 2008-11-12 |
JP2008533083A (en) | 2008-08-21 |
PL1863791T3 (en) | 2009-04-30 |
EA200701843A1 (en) | 2008-02-28 |
WO2006100026A8 (en) | 2007-02-08 |
KR20070113317A (en) | 2007-11-28 |
CN101146790A (en) | 2008-03-19 |
WO2006100026A1 (en) | 2006-09-28 |
RS50722B (en) | 2010-08-31 |
PT1863791E (en) | 2008-12-15 |
EP1992349B8 (en) | 2013-10-09 |
JP4210322B2 (en) | 2009-01-14 |
SI1863791T1 (en) | 2009-04-30 |
ES2317512T3 (en) | 2009-04-16 |
DK1863791T5 (en) | 2010-10-04 |
DE502006002066D1 (en) | 2008-12-24 |
EP1992349A1 (en) | 2008-11-19 |
ZA200705852B (en) | 2009-12-30 |
EP1863791A1 (en) | 2007-12-12 |
CN101146799A (en) | 2008-03-19 |
DK1863791T3 (en) | 2009-02-16 |
EA012590B1 (en) | 2009-10-30 |
HRP20090011T3 (en) | 2009-02-28 |
MY144635A (en) | 2011-10-14 |
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