TH89299A - N-hydroxyamide That was replaced at the position With tri-cyclic moo That is a histone inhibitor Deacetylase, and pharmaceutical mixtures that contain them - Google Patents
N-hydroxyamide That was replaced at the position With tri-cyclic moo That is a histone inhibitor Deacetylase, and pharmaceutical mixtures that contain themInfo
- Publication number
- TH89299A TH89299A TH601001055A TH0601001055A TH89299A TH 89299 A TH89299 A TH 89299A TH 601001055 A TH601001055 A TH 601001055A TH 0601001055 A TH0601001055 A TH 0601001055A TH 89299 A TH89299 A TH 89299A
- Authority
- TH
- Thailand
- Prior art keywords
- replaced
- hydroxyamide
- moo
- tri
- cyclic
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 108010033040 Histones Proteins 0.000 title abstract 2
- ZXKINMCYCKHYFR-UHFFFAOYSA-N aminooxidanide Chemical compound [O-]N ZXKINMCYCKHYFR-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000000126 substance Substances 0.000 claims 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 3
- 108090000353 Histone deacetylase Proteins 0.000 abstract 3
- -1 N-hydroxyamide amide Chemical class 0.000 abstract 1
Abstract
DC60 (06/06/49) N-ไฮดรอกซีเอไมด์ของ n-แอลคิล คาร์บอกซิลิก แอซิด ที่ถูกแทนที่ที่ตำแหน่งโอเมกาด้วย ระบบไตรไซคลิกที่เหมาะสม ชนิดใหม่ ที่ถูกกำหนดลักษณะเฉพาะโดยวงแหวนที่มีสมาชิก 7 ตัว ที่อยู่ตรงกลาง , ซึ่งมีแอคติวิตี้เป็นสารยับยั้งของฮิสโทน ดีอะเซทิเลส (HDAC) N-ไฮดรอกซีเอไมด์ของ n-แอลคิล คาร์บอกซิลิก แอซิด ที่ถูกแทนที่ที่ตำแหน่งโอเมกาด้วย ระบบไตรไซคลิกที่เหมาะสม ชนิดใหม่ ที่ถูกกำหนดลักษณะเฉพาะโดยวงแหวนที่มีสมาชิก 7 ตัว ที่อยู่ตรงกลาง , ซึ่งมีแอคติวิตี้เป็นสารยับยั้งของฮิสโทน ดีอะเซทิเลส (HDAC) สิทธิบัตรยา DC60 (06/06/49) N-hydroxyamide amide of n-alkyl carboxylic acid that was also replaced at omega position. A new type of suitable tricyclic system characterized by a medial 7-membered ring, which has the activity as a inhibitor of histone deacetylase (HDAC) N-Hi. The n-alkyl carboxylic acid droxymide was replaced at the omega position. A new suitable tricyclic system characterized by a medial seven-membered ring, which has the activity as an inhibitor of histone diazetylase (HDAC).
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH89299B TH89299B (en) | 2008-04-10 |
| TH89299A true TH89299A (en) | 2008-04-10 |
Family
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