TH89299B - N-hydroxyamide That was replaced at the Omega position with a tri-cyclic group That are histone deacetylase inhibitors, and pharmaceutical mixtures that contain them - Google Patents
N-hydroxyamide That was replaced at the Omega position with a tri-cyclic group That are histone deacetylase inhibitors, and pharmaceutical mixtures that contain themInfo
- Publication number
- TH89299B TH89299B TH601001055A TH0601001055A TH89299B TH 89299 B TH89299 B TH 89299B TH 601001055 A TH601001055 A TH 601001055A TH 0601001055 A TH0601001055 A TH 0601001055A TH 89299 B TH89299 B TH 89299B
- Authority
- TH
- Thailand
- Prior art keywords
- hydroxyamide
- replaced
- histone deacetylase
- tri
- contain
- Prior art date
Links
- ZXKINMCYCKHYFR-UHFFFAOYSA-N aminooxidanide Chemical compound [O-]N ZXKINMCYCKHYFR-UHFFFAOYSA-N 0.000 title abstract 2
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000006168 tricyclic group Chemical group 0.000 title 1
- 239000000126 substance Substances 0.000 claims 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 2
- 108090000353 Histone deacetylase Proteins 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
Abstract
N-ไฮดรอกซีเอไมด์ของ n-แอลคิล คาร์บอกซิลิก แอซิด ที่ถูกแทนที่ที่ตำแหน่งโอเมกาด้วย ระบบไตรไซคลิกที่เหมาะสม ชนิดใหม่ ที่ถูกกำหนดลักษณะเฉพาะโดยวงแหวนที่มีสมาชิก 7 ตัว ที่อยู่ตรงกลาง , ซึ่งมีแอคติวิตี้เป็นสารยับยั้งของฮิสโทน ดีอะเซทิเลส (HDAC) N-hydroxyamide of n-alkyl carboxylic acid was replaced at the omega position. A new type of suitable tricyclic system characterized by a medial 7-membered ring, which has the activity as a inhibitor of histone deacetylase (HDAC).
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH89299B true TH89299B (en) | 2008-04-10 |
| TH89299A TH89299A (en) | 2008-04-10 |
Family
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| TH89299B (en) | N-hydroxyamide That was replaced at the Omega position with a tri-cyclic group That are histone deacetylase inhibitors, and pharmaceutical mixtures that contain them | |
| TH89299A (en) | N-hydroxyamide That was replaced at the position With tri-cyclic moo That is a histone inhibitor Deacetylase, and pharmaceutical mixtures that contain them |