TH86243B - Macro cyclic inhibitors of hepatitis C virus - Google Patents
Macro cyclic inhibitors of hepatitis C virusInfo
- Publication number
- TH86243B TH86243B TH601003560A TH0601003560A TH86243B TH 86243 B TH86243 B TH 86243B TH 601003560 A TH601003560 A TH 601003560A TH 0601003560 A TH0601003560 A TH 0601003560A TH 86243 B TH86243 B TH 86243B
- Authority
- TH
- Thailand
- Prior art keywords
- hepatitis
- virus
- hydrogen
- macro cyclic
- cyclic inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 241000711549 Hepacivirus C Species 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 239000000126 substance Substances 0.000 claims abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
- 150000001204 N-oxides Chemical class 0.000 claims abstract 2
- 125000004429 atom Chemical group 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract 2
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 229940000425 combination drug Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
Abstract
ตัวยับยั้ง HCV ที่มีสูตร (I) (สูตรเคมี) (I) และ N - ออกไซด์, เกลือ, และสเทริโอไอโซเมอร์ ของสารเหล่านั้น ซึ่งเส้นประเลือกแทน พันธะคู่ระหว่าง อะตอม C7 และ C8; R1 คือ ไฮโดรเจนหรือ C1-6 แลอคิล; R2 คือไฮโดรเจน หรือ C1-6แอลคิล ; และ n คือ 3, 4, 5, หรือ 6; สารผสมทางเภสัชศาสตร์ ซึ่งมีสารประกอบ (I) และกรรมวิธีเตรียมสารประกอบ (I) ตัวยารวมที่มีชีวประมาณออกฤทธิ์ของตัวยังยั้ง HCV ที่มีสูตร (I) กับไรโทแนเวียร์ได้รับการกำหนดไว้ อีกด้วย HCV inhibitors with formulas (I) (chemical formulas) (I) and N-oxides, salts, and stereosomers. Of those substances Which the dash chooses instead Double bond between C7 and C8 atoms; R1 is hydrogen or C1-6 lagyl; R2 is hydrogen or C1-6 alkyl; And n is 3, 4, 5, or 6; Pharmaceutical mixtures The bioactive combination drug (I) and the compound (I) inhibitor also inhibits the formulation of HCV (I) with the rhatonavir.
Claims (3)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH86243A TH86243A (en) | 2007-08-30 |
| TH86243B true TH86243B (en) | 2007-08-30 |
Family
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