TH4420B - Hepatitis B vaccine freeze-dried under pressure drop (process) - Google Patents
Hepatitis B vaccine freeze-dried under pressure drop (process)Info
- Publication number
- TH4420B TH4420B TH8501000131A TH8501000131A TH4420B TH 4420 B TH4420 B TH 4420B TH 8501000131 A TH8501000131 A TH 8501000131A TH 8501000131 A TH8501000131 A TH 8501000131A TH 4420 B TH4420 B TH 4420B
- Authority
- TH
- Thailand
- Prior art keywords
- hepatitis
- under pressure
- dried under
- pressure drop
- dried
- Prior art date
Links
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 title abstract 2
- 229940124736 hepatitis-B vaccine Drugs 0.000 title abstract 2
- 241000270666 Testudines Species 0.000 claims 2
- 238000005452 bending Methods 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 241000700721 Hepatitis B virus Species 0.000 abstract 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052782 aluminium Inorganic materials 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Abstract
การเตรียมเฮพาไททิส บี วัคซีนแห้งที่ประกอบด้วย แอนติเจนผิวหน้าของเฮพาไททิสบีไวรัส ที่บริสุทธิ์ซึ่งเตรียมได้จากกรีคอมบิแนนท์จุลินทรีย์ที่สามารถผลิต HBs แอนติเจนได้และแอนติเจนนี้ดูดซับอยู่บนอะลูมินัมเจลและถูกทำให้แห้งในขณะที่มีสารที่ทำให้เสถียรอยู่ด้วยสามารถทำได้โดยมีขั้นตอนดังนี้คือ เติมอะลูมินัมเจลและสารที่ทำให้เสถียรลงไปใน HBs แอนติเจนบริสุทธิ์ที่มาจากรีคอมบิแนนท์แล้วนำสารผสมไปให้ทำแห้งโดยการแช่แข็งภายใต้ความดัน ผลิตภัณฑ์แห้งที่เตรียมได้ดังกล่าวสามารถเก็บไว้ได้อย่างเสถียรเป็นระยะนานโดยไม่สูญเสียแอติเจนไทเทอร์และมีประโยชน์มากในการนำมาใช้ป้องกันการติดเชื้อโดยเฮพาไททิสบีไวรัส สิทธิบัตรยา Dry preparation of the hepatitis B vaccine containing Surface antigen of hepatitis B virus The pure, prepared from microbial recombinant capable of producing HBs antigens, and this antigen are adsorbed on the aluminum gel and dried while the stabilizer is present. Is Aluminum gel and stabilizer are added to HBs, purified recombinant antigens, and dried by freeze-dried under pressure. The dry prepared product can be stored for a long period of time without depletion of the antigen and is very useful in the prevention of infection by hepatitis B virus.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH3859A TH3859A (en) | 1987-02-02 |
| TH4420B true TH4420B (en) | 1995-04-03 |
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