TH29546B - ตัวรีดิวซ์สำหรับรีดัคทีฟแอลคิเลชันของสารปฏิชีวนะไกลโคเพปไทด์ - Google Patents
ตัวรีดิวซ์สำหรับรีดัคทีฟแอลคิเลชันของสารปฏิชีวนะไกลโคเพปไทด์Info
- Publication number
- TH29546B TH29546B TH9701004748A TH9701004748A TH29546B TH 29546 B TH29546 B TH 29546B TH 9701004748 A TH9701004748 A TH 9701004748A TH 9701004748 A TH9701004748 A TH 9701004748A TH 29546 B TH29546 B TH 29546B
- Authority
- TH
- Thailand
- Prior art keywords
- clause
- cupic
- glycopeptide
- soluble copper
- reducing agent
- Prior art date
Links
- 239000003910 polypeptide antibiotic agent Substances 0.000 title claims 5
- 239000003638 chemical reducing agent Substances 0.000 title claims 3
- 238000005932 reductive alkylation reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims 11
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 4
- 229910052802 copper Inorganic materials 0.000 claims 4
- 239000010949 copper Substances 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 2
- 150000001299 aldehydes Chemical class 0.000 claims 2
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 1
- OBETXYAYXDNJHR-UHFFFAOYSA-M 2-ethylhexanoate Chemical compound CCCCC(CC)C([O-])=O OBETXYAYXDNJHR-UHFFFAOYSA-M 0.000 claims 1
- UVZMNGNFERVGRC-UHFFFAOYSA-N 4-cyclohexylbutanoic acid Chemical compound OC(=O)CCCC1CCCCC1 UVZMNGNFERVGRC-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- 108010015899 Glycopeptides Proteins 0.000 claims 1
- 102000002068 Glycopeptides Human genes 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 229910000085 borane Inorganic materials 0.000 claims 1
- NNTOJPXOCKCMKR-UHFFFAOYSA-N boron;pyridine Chemical group [B].C1=CC=NC=C1 NNTOJPXOCKCMKR-UHFFFAOYSA-N 0.000 claims 1
- SHZIWNPUGXLXDT-UHFFFAOYSA-N caproic acid ethyl ester Natural products CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 claims 1
- PTVDYARBVCBHSL-UHFFFAOYSA-N copper;hydrate Chemical group O.[Cu] PTVDYARBVCBHSL-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 230000002829 reductive effect Effects 0.000 claims 1
- 239000012279 sodium borohydride Substances 0.000 claims 1
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 1
Claims (2)
1. กรรมวิธีของข้อใดข้อหนึ่งข้อถือสิทธิข้อ 1 ถึง 9 ซึ่งสารปฏิชีวนะไกลโคเพปไทด์นั้น คือ A82845B 1
2. กรรมวิธีของข้อใดข้อหนึ่งข้อถือสิทธิข้อ 1 ถึง 11 ซึ่งคีโทน หรือแอลดีไฮด์นั้นคือ 4\'-คลอโร -4- ไบเฟนิลคาร์บอกแซลดีไฮด์
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH36730A TH36730A (th) | 2000-01-14 |
| TH29546B true TH29546B (th) | 2011-01-27 |
Family
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