TH2746B - Production of the antibiotic Kibdelosporangium aridum Shearer. - Google Patents
Production of the antibiotic Kibdelosporangium aridum Shearer.Info
- Publication number
- TH2746B TH2746B TH8401000333A TH8401000333A TH2746B TH 2746 B TH2746 B TH 2746B TH 8401000333 A TH8401000333 A TH 8401000333A TH 8401000333 A TH8401000333 A TH 8401000333A TH 2746 B TH2746 B TH 2746B
- Authority
- TH
- Thailand
- Prior art keywords
- aad
- antibiotic
- production
- complex
- nov
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract 4
- 241000203796 Kibdelosporangium aridum Species 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- ZHRODENVJFUAFN-PNKCYDOPSA-N aad 216 Chemical compound CCC(=O)N[C@H]1C(O)O[C@H](C(O)=O)[C@@H](O)[C@@H]1O.N1C(=O)C(NC(C(NC)C=2C=C(O3)C(O)=CC=2)=O)C(O)C(C=C2Cl)=CC=C2OC(C=2O)=CC4=CC=2OC(C(=C2)Cl)=C(Cl)C=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C5C=2)C(O)=O)=O)NC(=O)C5NC(=O)C4NC(=O)C1C1=CC3=CC(O)=C1Cl ZHRODENVJFUAFN-PNKCYDOPSA-N 0.000 claims abstract 6
- 239000007788 liquid Substances 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000203790 Kibdelosporangium Species 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 238000009629 microbiological culture Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
Abstract
การประดิษฐ์นี้กล่าวถึงการผลิตยาปฏิชีวนะใหม่ในกลุ่มยาปฏิชีวนะคล้ายคลึงแวนโคมัยซิน คือ สารประกอบเชิงซ้อนของAAD 216 โดยการหมักเชื้อ Kibdelosporangium aridum Shearer gen. nov., Sp.nov. ATCC 39323 ในอาหารเหลวภายใต้สภาวะที่มีอากาศ สารประกอบเชิงซ้อน AAD 216 และองค์ประกอบส่วนใหญ่ของมันคือ AAD 216A, AAD 216B และ AAD 216C มีฤทธิ์ในการเป็นยาปฏิชีวนะ และออกฤทธิ์ในการกระตุ้นการเจริญเติบโต This invention addresses the production of a new antibiotic in the vancomycin-like antibiotic class AAD 216 complex by fermentation. Kibdelosporangium aridum Shearer gen. nov., Sp.nov. ATCC 39323 in liquid medium under aerobic conditions. The complex AAD 216 and most of its constituents AAD 216A, AAD 216B and AAD 216C are active as antibiotics. and act to stimulate growth
Claims (4)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH2142A TH2142A (en) | 1985-01-02 |
| TH2746B true TH2746B (en) | 1992-01-28 |
Family
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