TH17880C3 - Composition of nanoparticles containing pharmaceutical active ingredients for the preparation of in vitro pharmaceutical formulations. - Google Patents

Abstract

Invention Summary, which appears on the advert page ReadFile:------05/04/2018------(OCR)Page 1 of 1 Page Invention Summary This invention relates to elements of the Invention. Pharmaceutical active ingredient nanoparticles for the preparation of in vitro pharmaceutical formulations consist of a) 5-30 percent by weight of the total active ingredients, b) 0.5-5 percent by weight of the total ingredient, c) solid fat, 0.5-5 percent by weight of the total ingredient. Dissolving agent 0.5-5% by weight of the total mixture, d) surfactant 2-20 percent by weight of the total mixture, and e) 60-92 percent by weight of the total mixture, with its characteristics. That is, such nanoparticles can store at least 3 important pharmaceutical substances, which such nanoparticles have the ability to penetrate into the skin to enhance the effect and enhance the properties of important substances that are retained and stable. It is suitable for preparation of pharmaceutical formulations without causing skin irritation.-------------- This invention involves the composition of nanoparticles containing Active pharmaceutical substances for the preparation of pharmaceutical formulations for in vitro use include: Lifting) 5-30 percent by weight of pharmaceutical essence of total ingredients b) Solid fat 0.5-5 percent by weight of total ingredients c) Solubility agent 0.5-5 percent by weight of total ingredients d) Surfactant surface 2-20% by weight of the total ingredients and e) water 60-92% by weight of the total ingredients. It is characterized by the fact that such nanoparticles can hold at least three active pharmaceutical substances that such nanoparticles contain. The ability to penetrate into the skin has good synergistic effect and enhance the properties of important substances that retain and have good stability, suitable for preparing pharmaceutical formulations without causing irritation to skin

Claims (1)

1. Claims (all) which will not appear on advertisement page:Revised 30/11/2018 Claims 1. The composition of nanoparticles containing active pharmaceutical substances for the preparation of pharmaceutical formulations. For use outside the body A. Active pharmaceutical substances 5-30 percent by weight of total ingredients b. Solid fat 0.5-5 percent by weight of total ingredients C. Dissolution enhancer 0.5-5 percent by weight of all ingredients. D. Surfactant 2-20 percent by weight of the total mixture E. Water 60-92% by weight of the total mixture The unique feature is that such nanoparticles can effectively store important pharmaceutical substances. At least 3 types------05/04/2018------(OCR) Page 1 of 2 Pages Claims 1. Composition of nanoparticles containing with important pharmaceutical substances for preparing pharmaceutical formulations For use outside the body A. Active pharmaceutical substances 5-30 percent by weight of all ingredients b. Solid fat 0.5-5 percent by weight of all ingredients C. Dissolution enhancer 0.5-5 percent by weight of all ingredients. D. Surfactants 2-20 percent by weight of the total ingredients. Mon. Water 60-92 percent by weight of all ingredients. Its characteristic is that such nanoparticles can store at least 3 active pharmaceutical substances. Important pharmaceutical substances are natural extracts from essential oils, extracts. coarse or mixture of such substances3. The composition of nanoparticles packed with active pharmaceutical substances according to claim 1 or 2. The important pharmaceutical substances can be selected from Plai (Plai), Turmeric (Tumeric), Galangal (Galanga), Clove. (Clove), Rosemary (Wintergreen), Betel (Plu), Lemongrass (Lemongrass), Ginger (Ginger), Camphor (Camphor), Borneo (Bomeol), Mulberry (Mulberry), Pomegranate (Shikakai), Basil (Basil) ),peppermint (Peppermint), tamarind leaves (Tamarind), bergamot (Bergamot), lotus (Lotus), lavender. (Lavender), chamomile (Chamomile) or a mixture of such substances. 4. Composition of nanoparticles containing active pharmaceutical substances according to one of the claims Previously, the important pharmaceutical substances were a mixture of turmeric (Tumeric), cloves (Clove), galangal. (Galanga), Lavender (Lavender), Plai (Plai) and Rum (Wintergreen)5. The composition of nanoparticles containing active pharmaceutical substances according to one of the claims Previously, where active pharmaceutical substances amounted to between 15-20 percent by weight of all ingredients Page 2 of the number 2 pages 6. The composition of nanoparticles containing active pharmaceutical substances according to claim 1, where Solid fat is obtained from citylpalmetate (Cetylpalmetate), canubawax (Canubawax), compound. Compritolwax or its mixture 7. The composition of nanoparticles containing active pharmaceutical substances according to claim 1, where substances Improves solubility, selectable from ethyl alcohol (Ethylalcohol), ethoxydiglycol. (Ethoxydiglycol), Butylene Glycol (Butyleneglycol), Propylene Glycol (PropyleneGlycol), Di Propylene glycol (Dipropyleneglycol) or its mixture 8. The composition of nanoparticles containing active pharmaceutical substances according to claim 1, where substances Surfactants can be selected from Sorbitanmonolaurate, Poloxamer. (Poloxamer), polysorbate (Polysorbate), Cetearyl alcohol - Kodo - glucoside (Cetearyl Alcohol-Coco-Glucoside) or mixtures thereof 9. The composition of nanoparticles containing active pharmaceutical substances according to one of the claims Previously, the composition was supplemented with additives in the amount of between 0.1-5. Percent by weight of all ingredients1 0. The composition of nanoparticles containing active pharmaceutical substances according to claim 9, where Ash additives can be obtained from styling agents, thickeners, anti-oxidants or mixtures of Such substances ------------ 1. The composition of nanoparticles containing active pharmaceutical substances for the preparation of pharmaceutical formulations. For use outside the body A. Active pharmaceutical substances 5-30 percent by weight of total ingredients b. Solid fat 0.5-5 percent by weight of total ingredients C. Dissolution enhancer 0.5-5 percent by weight of all ingredients. D. Surfactant 2-20 percent by weight of the total mixture E. Water 60-92% by weight of the total mixture Its characteristic is that such nanoparticles can store at least 3 active pharmaceutical substances. Active pharmaceutical substances are natural extracts selected from essential oils, extracts. coarse or mixtures thereof 3. Composition of nanoparticles containing active pharmaceutical substances according to claim 1 or 2. The important pharmaceutical substances can be selected from Plai (Plai), Turmeric (Tumeric), Galangal (Galanga), Clove. (Clove), Rosemary (Wintergreen), Betel (Plu), Lemongrass (Lemongrass), Ginger (Ginger), Camphor (Camphor), Borneol (Borneol), Mulberry (Mulberry), Orange leaves (Shikakai), Basil ( Basil), mint (Peppermint), tamarind leaves (Tamarind), bergamot (Bergamot), lotus (Lotus), lavender. (Lavender), chamomile (Chamomile) or a mixture of such substances. 4. Composition of nanoparticles containing active pharmaceutical substances according to one of the claims Previously, the important pharmaceutical substances were a mixture of turmeric (Tumeric), cloves (Clove), galangal. (GaLanga), lavender (Lavender), Plai (Plai) and ragweed (Wintergreen). Previously, where active pharmaceutical substances amounted to between 15-20 percent by weight of all ingredients 6. The composition of nanoparticles containing active pharmaceutical substances according to claim 1, where Solid fats can be selected from Cetylpalmetate, Canubawax, Compound. Compritolwax or its mixture 7. The composition of nanoparticles containing active pharmaceutical substances according to claim 1, where substances Improves solubility, selectable from ethyl alcohol (Ethylalcohol), ethoxydiglycol. (Ethoxydiglycol), Butylene Glycol (Butyleneglycol), Propylene Glycol (PropyleneGlycol), Di Propylene glycol (Dipropyleneglycol) or its mixture 8. The composition of nanoparticles containing active pharmaceutical substances according to claim 1, where substances Surfactants can be selected from Sorbitanmonolaurate, Poloxamer. (Poloxamer), polysorbate (Polysorbate), Cetearyl alcohol - Coco - glucoside (Cetearyl Alcohol-Coco-Glucoside) or mixtures thereof 9. The composition of nanoparticles containing active pharmaceutical substances according to one of the claims Previously, the composition was supplemented with additives in the amount of between 0.1-5. Percent by weight of all ingredients1 0. The composition of nanoparticles for transdermal delivery according to claim 9, where additives Choose from preservatives, thickeners, antioxidants or mixtures of them.