TH169587A - Ethyl derivatives that are modulators of MGLUR5 receptor activity. - Google Patents
Ethyl derivatives that are modulators of MGLUR5 receptor activity.Info
- Publication number
- TH169587A TH169587A TH1501002120A TH1501002120A TH169587A TH 169587 A TH169587 A TH 169587A TH 1501002120 A TH1501002120 A TH 1501002120A TH 1501002120 A TH1501002120 A TH 1501002120A TH 169587 A TH169587 A TH 169587A
- Authority
- TH
- Thailand
- Prior art keywords
- syndrome
- formula
- depression
- present
- chemical formula
- Prior art date
Links
- 101150087728 Grm5 gene Proteins 0.000 title 1
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 title 1
- 208000011580 syndromic disease Diseases 0.000 claims abstract 6
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims abstract 4
- 239000000126 substance Substances 0.000 claims abstract 3
- 208000019901 Anxiety disease Diseases 0.000 claims abstract 2
- 206010003805 Autism Diseases 0.000 claims abstract 2
- 208000020706 Autistic disease Diseases 0.000 claims abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical group [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract 2
- 208000018737 Parkinson disease Diseases 0.000 claims abstract 2
- 210000001766 X chromosome Anatomy 0.000 claims abstract 2
- 150000008043 acidic salts Chemical class 0.000 claims abstract 2
- 230000003281 allosteric effect Effects 0.000 claims abstract 2
- 230000036506 anxiety Effects 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims abstract 2
- 150000004673 fluoride salts Chemical group 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 230000002503 metabolic effect Effects 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 239000003607 modifier Substances 0.000 claims abstract 2
- 230000003287 optical effect Effects 0.000 claims abstract 2
- 150000003431 steroids Chemical class 0.000 claims abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
Abstract
การประดิษฐ์ปัจจุบันเกี่ยวข้องกับอนุพันธ์เอธินิล (ethylnyl) ของสูตร I (สูตรเคมี) I ที่ซึ่ง Y คือ N หรือ CH; R1 คือฟลูออไรหรือคลอไร; R2 คือไฮโดรเจนหรือเมธิล; หรือกับเกลือที่เติมกรดที่ยอมรับได้ทางเภสัชกรรม, กับสารผสมราวึมิก, หรือกับอีแนนทิ โอเมอร์ที่สอดคล้องของสิ่งนั้นและ/หรือออพติคัลไอไซเมอรืและ/หรือสเตอริโโซเมอรืของสิ่ง นั้น ในปัจจุบันได้ถูกพบอย่างน่าแปลใจว่าสารประกอบของสูตรทั้วไป I เป็นสารต้านเมตาโบ โทรปิกกลูตาเมตรีเวปเตอร์ (สารปรับอัลโลสเตอริกลบ) สำหรับใช้ในการรับษาอาการกังวล และอากเจ็บปวด, ภาวะซึมเสร้า, กลุ่มเศร้า, กลุ่มอาการโครโมโซม X เปราะบาง, กลุ่มโรคออทิสติก, โรค พาร์กินสัน, และดดรคกรดไหลย้อน (GERD) สิทธิบัตรยา The present invention involves an ethylnyl derivative of formula I (chemical formula) I, where Y is N or CH; R1 is fluoride or chloride; R2 is hydrogen or methyl; Or with a chemically acceptable acidic salt, with a rye mixture, or with an enanthi The corresponding ome of the thing and / or the optical isomer and / or the steroid of that present have been implicitly found that the compound of the whole formula Go I is a metabolic agent. Tropiglutametriwepters (Negative allosteric modifiers) for use in the treatment of anxiety And pain syndrome, depression, depression, fragile X chromosome syndrome, autism syndrome, Parkinson's disease, and acid reflux (GERD) drug patents.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH169587A true TH169587A (en) | 2017-10-27 |
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