TH167680A - Ethyl derivatives as a modulator of activity of MGLUR5 receptor. - Google Patents
Ethyl derivatives as a modulator of activity of MGLUR5 receptor.Info
- Publication number
- TH167680A TH167680A TH1501002107A TH1501002107A TH167680A TH 167680 A TH167680 A TH 167680A TH 1501002107 A TH1501002107 A TH 1501002107A TH 1501002107 A TH1501002107 A TH 1501002107A TH 167680 A TH167680 A TH 167680A
- Authority
- TH
- Thailand
- Prior art keywords
- formula
- gerd
- ethyl derivatives
- modulator
- disease
- Prior art date
Links
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 title claims abstract 3
- 230000000051 modifying Effects 0.000 title claims abstract 3
- 102100006612 GRM5 Human genes 0.000 title 1
- 101700027086 GRM5 Proteins 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 201000006860 gastroesophageal reflux disease Diseases 0.000 claims abstract 4
- 208000009471 Gastroesophageal Reflux Diseases 0.000 claims abstract 3
- 206010017885 Gastrooesophageal reflux disease Diseases 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 3
- 206010002855 Anxiety Diseases 0.000 claims abstract 2
- 206010057666 Anxiety disease Diseases 0.000 claims abstract 2
- 208000001914 Fragile X Syndrome Diseases 0.000 claims abstract 2
- 108009000484 Fragile X Syndrome Proteins 0.000 claims abstract 2
- 206010061536 Parkinson's disease Diseases 0.000 claims abstract 2
- 150000008043 acidic salts Chemical class 0.000 claims abstract 2
- 230000003281 allosteric Effects 0.000 claims abstract 2
- 230000036506 anxiety Effects 0.000 claims abstract 2
- 201000007185 autism spectrum disease Diseases 0.000 claims abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 claims abstract 2
- 108010070004 glucose receptor Proteins 0.000 claims abstract 2
- 230000003287 optical Effects 0.000 claims abstract 2
Abstract
การประดิษฐ์เกี่ยวข้องกับอนุพันธ์เอไทนิลตามสูตร I (สูตรเคมี) I โดยที่ Y เป็น N หรือ CH Rl เป็นฟลูออโรหรือคลอโร หรือเกี่ยวข้องกับเกลือที่เกิดจากการเติมกรดซึ่งเป็นที่ยอมรับทางเภสัชกรรม, ของผสมราซีมิก หรือ อิแนนทิโอเมอร์และ/หรือออปทิคัลไอโซเมอร์และ/หรือสเตอริโอไอโซเมอร์ที่สอดคล้องกันของสาร ดังกล่าว ขณะนี้มีการค้นพบอย่างไม่คาดหมายว่าสารประกอบตามสูตรทั่งไป I เป็นแอนตะกอนิสต์ ของเมทาโบโทรปิกกลูทาเมตรีเซปเตอร์ (เนกาทีฟแอลโลสเตอริกโมดูเลเตอร์) สำหรับใช้งานในการรักษา ความวิตกกังวลและอาการปวด, ภาวะซึมเศร้า, แฟรกไจล์-เอ็กซ์ซินโดรม, ความผิดปกติแบบออทิสซึม สเปกตรัม, โรคพาร์กินสัน และโรคกรดไหลย้อน (GERD) สิทธิบัตรยา Invention involves ethyl derivatives according to the formula I (chemical formula) I, where Y is N or CH Rl is fluoro or chloro. Or pertaining to pharmacologically acceptable acidic salts, razamic or inanthiomers and / or optical isomers and / or stereoisomers. It is now unexpectedly discovered that compounds according to the general formula I to be an anthraconist. Of metabotropic glucose receptor (Negative Allosteric Modulator) for use in the treatment of Anxiety and Pain, Depression, Fragile-X Syndrome, Autism Spectrum Disorders, Parkinson's Disease And acid reflux disease (GERD) drug patents.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH167680A true TH167680A (en) | 2017-09-07 |
| TH167680B TH167680B (en) | 2017-09-07 |
Family
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