TH167694A - Ethylenediamin Which is a metabolic glutamate receptor antagonist - Google Patents
Ethylenediamin Which is a metabolic glutamate receptor antagonistInfo
- Publication number
- TH167694A TH167694A TH1601000045A TH1601000045A TH167694A TH 167694 A TH167694 A TH 167694A TH 1601000045 A TH1601000045 A TH 1601000045A TH 1601000045 A TH1601000045 A TH 1601000045A TH 167694 A TH167694 A TH 167694A
- Authority
- TH
- Thailand
- Prior art keywords
- formula
- glutamate receptor
- ethylenediamin
- receptor antagonist
- syndrome
- Prior art date
Links
- PIICEJLVQHRZGT-UHFFFAOYSA-N 1,2-ethanediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 title 1
- 239000003825 glutamate receptor antagonist Substances 0.000 title 1
- 230000002503 metabolic Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 239000002253 acid Substances 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000000301 2-(3-chlorophenyl)ethyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 206010002855 Anxiety Diseases 0.000 abstract 1
- 206010057666 Anxiety disease Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 210000000349 Chromosomes Anatomy 0.000 abstract 1
- 208000009471 Gastroesophageal Reflux Diseases 0.000 abstract 1
- 206010017885 Gastrooesophageal reflux disease Diseases 0.000 abstract 1
- 102000016193 Metabotropic Glutamate Receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic Glutamate Receptors Proteins 0.000 abstract 1
- 206010061536 Parkinson's disease Diseases 0.000 abstract 1
- 230000003281 allosteric Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 201000002055 autistic disease Diseases 0.000 abstract 1
- 201000006860 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 abstract 1
- 230000000051 modifying Effects 0.000 abstract 1
- 201000010874 syndrome Diseases 0.000 abstract 1
Abstract
การประดิษฐ์ครั้งนี้เกี่ยวข้องกับอนุพันธ์เอทไธนิล (ethynyI) ตามสูตร I (สูตรเคมี) โดยที่ Y คือ N หรือ CH R1 คือไฮโดรเจน, ฟลูออโร หรือคลอโร; และ R2 คือ ไอโดรเจน หรืออัลคิลโมเลกุลต่ำ; หรือเกี่ยวข้องกับเกลือจากการเติมกรดที่ยอมรับได้ทางเภสัชกรรมของพวกมัน มันได้ถูกค้นพบอย่างน่าประหลาดใจในขณะนี้ว่า สารประกอบตามสูตรทั่วไป I คือ เมทาบอโทรปิค กลูตาเมต รีเซพเตอร์ แอนทาโกนิสต์ (metabotropic glutamate receptor antagunists) (สารปรับควบคุมอัลโลสเตอริกแบบลบ (Negative allosteric modulators)) สำหรับการใช้งานใน การบำบัด ภาวะวิตกกังวลและอาการปวด, ภาวะซึมเศร้า, กลุ่มอาการโรคโครโมโซนเอ็กซ์เปราะ, กลุ่มโรคออทิสติก, โรคพาร์กินสัน, และโรคกรดไหลย้อน (GERD): สิทธิบัตรยา This invention involves ethyny-derivative (ethynyI) according to formula I (chemical formula) where Y is N or CH R1 is hydrogen, fluoro, or chloro; And R2 is an idrogen or low molecular alkyl; Or pertaining to their pharmaceutical-acceptable acid salts It was now surprisingly discovered that Compounds according to the general formula I are metabotropic glutamate receptor antagunists (Negative allosteric modulators). )) For use in the treatment of anxiety and pain, depression, brittle chromosome X syndrome, autism syndrome, Parkinson's disease, and GERD. : Drug patent
Claims (3)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH167694A true TH167694A (en) | 2017-09-07 |
| TH1601000045A TH1601000045A (en) | 2017-09-07 |
| TH167694B TH167694B (en) | 2017-09-07 |
Family
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