TH14569C3 - Pharmacopoeia formulations for external use products - Google Patents

Abstract

1 page of the number 1 page summary of the invention This invention relates to the composition of the pharmaceutical formula. For products use Outside of the body containing: a) 5-50% by weight of nanoparticles containing pharmaceutical active substances; B) gelling agent amount 2.5-15% by weight; C) modifier medium amount of 0.2-0.5% by weight; D) additives 0.5-15% by weight and e) Pharmaceutical acceptable carriers (pharmaceutically acceptable carrier) for adjusting the dosage to 100 percent by weight. Whose characteristics are Such nanoparticles Able to store at least 3 kinds of important substances by the above formulation Has good stability And can increase the delivery of important substances Better into the skin, patent drug

Claims (9)

Disclaimer (all) which will not appear on the advertisement page. : ------ 05/04/2018 ------ (OCR) Page 1 of 2 pages. 1. Composition of the Pharmacy Formula For external use products Containing - nanoparticles containing at least three active pharmaceutical substances, 5-50% by weight; - Gelling agent amount 2.5-15% by weight; - neutralizer, 0.2-0.5 percent by weight; And - a pharmaceutical acceptable carrier (pharmaceutically acceptable carrier) for adjusting the dosage to 100 percent by weight. 2. Composition of the pharmaceutical formulation according to claim 1, where appropriate nanoparticles containing essential substances are capable of holding 5-10 substances. 3. Composition of the Pharmacy Formula According to claim 1 or 2, where active pharmaceutical substance is an active pharmaceutical substance for topical delivery of drugs. 4. Composition of the Pharmacy Formulation according to claim 1, where the nanoparticles containing pharmaceutical active substances are selectable from emulsion nanoparticles, lipid nanoparticles, solid lipid particles, polymer nanoparticles. Or a mixture of such substances 5. Composition of the Pharmacy Formula According to claim 4, wherein the nanoparticles containing A suitable pharmaceutical active substance is nanoparticle emulsion. 6. Composition of the Pharmacy Formula According to claim 1, where the gelling agent is selected from the substance group Emulsifying-Stabilizing Polymer, Acrylate Synthetic Polymer, Modified Synthetic Starch, Hydrogenated Wet Table Oil, Polymer Synthetic carbomer Or a mixture of such substances 7. Composition of the pharmaceutical formulation according to claim 1, where the neutralizing agent can be selected from triethanolamine, potassium hydroxide, sodium hydroxide. Or a mixture of such substances 8. Composition of Pharmacopoeia Formulation According to claim 1, where the pharmaceutical acceptable carrier Consisted of additive amount of 0.5-15% by weight of the ingredients of the formula, page 2 of the number of 2 pages. 9. Composition of Pharmacopoeia Formulation According to claim 8, where additives can be selected based on solvents, flavoring agents, preservatives, cooling additives. Or mixtures thereof. 1 0. Composition of a pharmaceutical formula. According to any of the 1-9 claims The steps are as follows: a. Dissolve the gelling agent. And a pharmaceutical acceptable carrier, then stir at 250-450 rpm until a homogeneous solution is obtained. B. Adjust the pH of the solution obtained from step a) with a neutralizer until there is PH value in the range of 5-7 C. Add nanoparticles containing pharmaceutical active ingredients. Into the prepared substance from step b) and stir continuously at 250-450 rpm until combined ------------ 1. Composition of the Pharmacy Formula For external use products Consisting of a) nanoparticles containing 5 to 50 percent of active pharmaceutical ingredients; B) gelling agent amount 2.5-15% by weight; C) neutralizing agents in the amount of 0.2-0.5 percent by weight; And d) a pharmaceutical acceptable carrier (pharmaceutically acceptable carrier) for adjusting the dosage to 100 percent by weight. Whose characteristics are Such nanoparticles Able to store at least 3 important substances 2. Composition of the Pharmacy Formula According to claim 1, the nanoparticles containing such vital substances can hold 5-10 active substances. 3. Composition of the Pharmacy Formula According to claim 1 or 2, where active pharmaceutical substance is an active pharmaceutical substance for topical delivery of drugs. 4. Composition of the Pharmacy Formula According to claim 1, where the nanoparticles containing pharmaceutical active substance in item a) can be selected from emulsion nanoparticles, fat nanoparticles, solid fat nanoparticles, polymer nanoparticles. Or a mixture of such substances 5. Composition of the Pharmacy Formula According to claim 4, wherein the nanoparticles containing The active pharmaceutical substance in a) is nano-emulsion. 6. Composition of the Pharmacy Formula According to claim 1, where the gelling agent in item b) is chosen from the emulsifying-stabilizing polymer group, the synthetic acrylate polymer. , Modified synthetic starch, hydrogenate wet table oil, synthetic polymer, carbomer Or a mixture of such substances 7. Composition of the Pharmacy Formula According to claim 1, where the neutralizing agent in c) can be selected from triethanolamine, potassium hydroxide, sodium hydroxide. Or a mixture of such substances 8. Composition of Pharmacopoeia Formulation According to claim 1, where the pharmaceutical acceptable carrier in section d) is supplemented with a 0.5-15% additive by weight of the composition of the formulation 9. Composition of Pharmacopoeia Formulation According to claim 8, where additives can be selected based on solvents, flavoring agents, preservatives, cooling additives. Or a mixture of such substances 1 0. Composition of a pharmaceutical recipe recipe In accordance with any of the previous claims provided that the aforementioned composition is prepared from a process containing i) gelling solution. And a pharmaceutical acceptable carrier, stir at 250- 450 rpm, until a homogeneous solution is obtained; ii) adjust the pH of the solution obtained from step i) with a neutralizer. Until the pH value is in the range 5-7 iii) Add nanoparticles containing pharmaceutical active ingredients. Into the prepared substance from step ii) and stir continuously at 250-450 rpm until blended.