TH126338A - - Google Patents

Info

Publication number

TH126338A

TH126338A TH901003267A TH0901003267A TH126338A TH 126338 A TH126338 A TH 126338A TH 901003267 A TH901003267 A TH 901003267A TH 0901003267 A TH0901003267 A TH 0901003267A TH 126338 A TH126338 A TH 126338A

Authority

TH

Thailand

Prior art keywords

substances

signal transduction

spirocyclic

salts

formula

Prior art date

2009-07-20

Links

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• 229940079593 drug Drugs 0.000 claims abstract 2
• 239000003814 drug Substances 0.000 claims abstract 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims 1
• 108010081348 HRT1 protein Hairy Proteins 0.000 claims 1
• 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
• VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 claims 1
• 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
• 239000000126 substance Substances 0.000 abstract 7
• 150000003839 salts Chemical class 0.000 abstract 4
• 230000019491 signal transduction Effects 0.000 abstract 4
• 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 3
• 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 3
• 125000000623 heterocyclic group Chemical group 0.000 abstract 3
• SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract 2
• 208000019693 Lung disease Diseases 0.000 abstract 2
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 2
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 2
• 201000010099 disease Diseases 0.000 abstract 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
• 230000000694 effects Effects 0.000 abstract 2
• CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 2
• 229960000367 inositol Drugs 0.000 abstract 2
• 210000004072 lung Anatomy 0.000 abstract 2
• 150000007522 mineralic acids Chemical class 0.000 abstract 2
• 239000000203 mixture Substances 0.000 abstract 2
• 150000007524 organic acids Chemical class 0.000 abstract 2
• 230000000144 pharmacologic effect Effects 0.000 abstract 2
• 238000002360 preparation method Methods 0.000 abstract 2
• 208000023504 respiratory system disease Diseases 0.000 abstract 2
• CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract 2
• 230000001225 therapeutic effect Effects 0.000 abstract 2
• 230000001173 tumoral effect Effects 0.000 abstract 2
• 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
• 230000003211 malignant effect Effects 0.000 abstract 1