TH122337B - Amino-heterocyclic compounds - Google Patents
Amino-heterocyclic compoundsInfo
- Publication number
- TH122337B TH122337B TH801002312A TH0801002312A TH122337B TH 122337 B TH122337 B TH 122337B TH 801002312 A TH801002312 A TH 801002312A TH 0801002312 A TH0801002312 A TH 0801002312A TH 122337 B TH122337 B TH 122337B
- Authority
- TH
- Thailand
- Prior art keywords
- formula
- amino
- alkyl
- heterocyclic compounds
- alryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010001897 Alzheimer's disease Diseases 0.000 abstract 1
- 230000001149 cognitive Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001537 neural Effects 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Abstract
การประดิษฐ์จัดเตรียมสารประกอบยับยั้ง PDE9ของสูตร (I), (สูตรเคมี) (I) และเกลือที่สามารถยอมรับทางเภสัชกรรมของสิ่งเหล่านี้, โดยที่ R1 R1, R2 และ R3 คือตามที่ถูกนิยาม ในที่นี้ องค์ประกอบทางเภสัชกรรมที่มีสารประกอบของสูตร I, และการใช้ของสิ่งเหล่านี้ในการรักษา ความผิดปกติของการเสื่อมของประสาทและเกี่ยวกับความรู้ความเข้าใจ, เช่น โรคแอลไซเมอร์และโรค จิตเภท, ยังถูกจัดเตรียม The invention provides a PDE9 inhibitor of formula (I), (chemical formula) (I) and a chemically acceptable salt of these, where R1, R1, R2 and R3 are, as defined here, the pharmaceutical component. Containing compounds of Formula I, and their use in the treatment Neural and cognitive dystrophy disorders, such as Alzheimer's disease and schizophrenia, are also being prepared.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH122337A TH122337A (en) | 2013-03-29 |
| TH122337B true TH122337B (en) | 2013-03-29 |
Family
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