TH125170B - Oxazine derivatives and their use as a BACE inhibitor (BACE inhibitor) for the treatment of neurological disorders. - Google Patents
Oxazine derivatives and their use as a BACE inhibitor (BACE inhibitor) for the treatment of neurological disorders.Info
- Publication number
- TH125170B TH125170B TH1201000270A TH1201000270A TH125170B TH 125170 B TH125170 B TH 125170B TH 1201000270 A TH1201000270 A TH 1201000270A TH 1201000270 A TH1201000270 A TH 1201000270A TH 125170 B TH125170 B TH 125170B
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- bace inhibitor
- treatment
- neurological disorders
- thio
- Prior art date
Links
- 101700044176 BACE Proteins 0.000 title abstract 3
- 101700051112 BACE1 Proteins 0.000 title abstract 3
- 102100015650 BACE1 Human genes 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 208000009025 Nervous System Disease Diseases 0.000 title 1
- 206010029305 Neurological disorder Diseases 0.000 title 1
- 150000004893 oxazines Chemical class 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 5
- 150000003839 salts Chemical group 0.000 claims abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 2
- 206010001897 Alzheimer's disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drugs Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Abstract
(สูตรเคมี)(l),การประดิษฐ์เกี่ยวข้องกับสารประกอบเฮเทอโรไซคลิกชนิดใหม่(heterocyclic compound)ของสูตร(I)ซึ่งทั้งหมดของกลุ่มสารแปรผันเป็นดังที่ถูกนิยามไว้ในรายละเอียดการประดิษฐ์ในรูปอิสระหรือในรูปเกลือ,กับสารเตรียมของสารนั้น,กับการใช้ยาของสารนั้นในฐานะตัวยับยั้ง BACEสำหรับการบำบัดโรคอัลไซเมอร์และกับยาที่ประกอบด้วยสารเหล่านั้น (Chemical formula) (l), the invention relates to a new heterocyclic compound (heterocyclic compound) of the formula (I) in which all of the variant groups are defined in the fabrication description in free form or in salt form, with the preparation of that substance, with the dosing of that substance as an inhibitor. BACE for the treatment of Alzheimer's disease and with drugs containing them
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH125170A TH125170A (en) | 2013-07-05 |
TH125170B true TH125170B (en) | 2013-07-05 |
Family
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