TH125824B - 2- amino-5,5-dipluoro-5,6-dihydro-4H-oxacin Which are inhibitors of Bace 1 and / or Bace 2 - Google Patents
2- amino-5,5-dipluoro-5,6-dihydro-4H-oxacin Which are inhibitors of Bace 1 and / or Bace 2Info
- Publication number
- TH125824B TH125824B TH1201002739A TH1201002739A TH125824B TH 125824 B TH125824 B TH 125824B TH 1201002739 A TH1201002739 A TH 1201002739A TH 1201002739 A TH1201002739 A TH 1201002739A TH 125824 B TH125824 B TH 125824B
- Authority
- TH
- Thailand
- Prior art keywords
- bace
- dihydro
- amino
- oxacin
- low molecular
- Prior art date
Links
- 101700051112 BACE1 Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 abstract 2
- -1 2-Amino-5,5-difluoro-5,6-dihydro-4H- [1,3] oxazin-4-yl Chemical group 0.000 abstract 1
- 206010001897 Alzheimer's disease Diseases 0.000 abstract 1
- 102100015650 BACE1 Human genes 0.000 abstract 1
- 208000001072 Type 2 Diabetes Mellitus Diseases 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000009117 preventive therapy Methods 0.000 abstract 1
Abstract
การประดิษฐ์ครั้งนี้เกี่ยวข้องข้องอนุพันธ์ 2-อะมิโน-5,5-ไดฟลูออโร-5,6-ไดไฮโดร-4H- [1,3]ออกซาซิน-4-อิล)-ฟีนิล]-เอไมด์ (2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)- phenyl]-amidederivatives) ตามสูตรI (สูตรเคมี) ซึ่งมีฤทธิ์ยับยั้ง BACE1 และ/หรือ BACE21, การผลิตของพวกมัน, องค์ประกอบเชิงเภสัชกรรมซึ่งมี พวกมัน และการใช้งานของพวกมันเป็นสารออกฤทธิ์เชิงการบำบัดรักษาโรค สารประกอบออกฤทธิ์ ตามการประดิษฐ์ครั้งนี้จะมีประโยชน์ในการบำบัดเชิงการรักษาและ/หรือเชิงการป้องกันโรค ได้แก่ โรคอัลไซเมอร์ และโรคเบาหวานชนิดที่ 2 This invention relates to derivatives. 2- amino-5,5-difluoro-5,6-dihydro-4H- [1,3] oxacin-4-il) - phenyl] - amide (2-Amino-5,5-difluoro-5,6-dihydro-4H- [1,3] oxazin-4-yl) - phenyl] -amidederivatives) according to formula I (chemical formula), which inhibits BACE1 and / or BACE21, their production, the pharmaceutical constituents which contain them and their use are therapeutic active substances. Active compound According to this invention, it can be useful in therapeutic and / or prophylactic therapy, including Alzheimer's disease. And type 2 diabetes
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH125824A TH125824A (en) | 2013-07-29 |
TH125824B true TH125824B (en) | 2013-07-29 |
Family
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