SV2013004584A - Procedimiento de manufactura para obtención de de n-bencil-2-(2-nitro-1h-imidazol-1-il)acetamida - Google Patents
Procedimiento de manufactura para obtención de de n-bencil-2-(2-nitro-1h-imidazol-1-il)acetamidaInfo
- Publication number
- SV2013004584A SV2013004584A SV2013004584A SV2013004584A SV2013004584A SV 2013004584 A SV2013004584 A SV 2013004584A SV 2013004584 A SV2013004584 A SV 2013004584A SV 2013004584 A SV2013004584 A SV 2013004584A SV 2013004584 A SV2013004584 A SV 2013004584A
- Authority
- SV
- El Salvador
- Prior art keywords
- bencil
- nitro
- imidazol
- synthesis
- acetamide
- Prior art date
Links
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 3
- 238000003786 synthesis reaction Methods 0.000 abstract 3
- YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 abstract 1
- 206010001935 American trypanosomiasis Diseases 0.000 abstract 1
- 208000024699 Chagas disease Diseases 0.000 abstract 1
- 241000223109 Trypanosoma cruzi Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SV2013004584A SV2013004584A (es) | 2013-11-19 | 2013-11-19 | Procedimiento de manufactura para obtención de de n-bencil-2-(2-nitro-1h-imidazol-1-il)acetamida |
| US15/033,238 US9765036B2 (en) | 2013-11-19 | 2014-11-19 | Production method for producing N-benzyl-2-(2-nitro-1H-imidazol-1-yl) acetamide |
| PCT/SV2014/000001 WO2015076760A1 (es) | 2013-11-19 | 2014-11-19 | Procedimiento de manufactura para obtención de n-bencil-2-(2-nitro-1h-imidazol-1-il)acetamida |
| BR112016011160-5A BR112016011160B1 (pt) | 2013-11-19 | 2014-11-19 | Procedimento de fabricação para obtenção de n-benzil-2- (2-nitro-1h-imidazol-1-ila) acetamida |
| JP2016554169A JP6425734B2 (ja) | 2013-11-19 | 2014-11-19 | Ｎ−ベンジル−２−（２−ニトロ−１ｈ−イミダゾール−１−イル）アセトアミドを得るための製造工程 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SV2013004584A SV2013004584A (es) | 2013-11-19 | 2013-11-19 | Procedimiento de manufactura para obtención de de n-bencil-2-(2-nitro-1h-imidazol-1-il)acetamida |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2013004584A true SV2013004584A (es) | 2015-09-07 |
Family
ID=53179913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2013004584A SV2013004584A (es) | 2013-11-19 | 2013-11-19 | Procedimiento de manufactura para obtención de de n-bencil-2-(2-nitro-1h-imidazol-1-il)acetamida |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9765036B2 (enExample) |
| JP (1) | JP6425734B2 (enExample) |
| BR (1) | BR112016011160B1 (enExample) |
| SV (1) | SV2013004584A (enExample) |
| WO (1) | WO2015076760A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017205622A1 (en) * | 2016-05-25 | 2017-11-30 | Savant Neglected Diseases, Llc | Method of making benznidazole |
| WO2019240671A1 (es) * | 2018-06-11 | 2019-12-19 | Ministerio De Educación, Ciencia Y Tecnología | Método de manufactura para la producción de benznidazol y su escalado industrial |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3505349A (en) * | 1966-04-18 | 1970-04-07 | Hoffmann La Roche | 2-nitro-imidazolyl-1-acetamides |
| WO2001087848A2 (en) * | 2000-05-17 | 2001-11-22 | Manufacturas Humberto Bukele E Hijos, S.A. De C.V. | Synthesis procedure for biphenylimidazolyl-(1)-phenylmethane and related compounds |
-
2013
- 2013-11-19 SV SV2013004584A patent/SV2013004584A/es active IP Right Grant
-
2014
- 2014-11-19 WO PCT/SV2014/000001 patent/WO2015076760A1/es not_active Ceased
- 2014-11-19 US US15/033,238 patent/US9765036B2/en active Active - Reinstated
- 2014-11-19 BR BR112016011160-5A patent/BR112016011160B1/pt active IP Right Grant
- 2014-11-19 JP JP2016554169A patent/JP6425734B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016539185A (ja) | 2016-12-15 |
| JP6425734B2 (ja) | 2018-11-21 |
| US20160289197A1 (en) | 2016-10-06 |
| WO2015076760A1 (es) | 2015-05-28 |
| BR112016011160A2 (enExample) | 2017-08-08 |
| BR112016011160B1 (pt) | 2022-07-05 |
| US9765036B2 (en) | 2017-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant |