SU976956A1 - Hemocoagulator - Google Patents

Description

The invention relates to medical technology, in particular to devices for measuring parameters of the blood coagulation process.

Thromboelastometers for recording blood coagulation and containing a cuvette for a blood sample under study, a float, an electromechanical actuator of a cuvette, a transducer to transduce blood into an electrical signal and an amplifier, an indication unit and measures of reaction time and area of thromboelastomacylmfm are known. informative parameters of the coagulation process.

Closest to the proposed technical essence digital. a thromboelastometer including a cuvette, a sensor-transducer of physical properties of a sample into an electrical signal, a voltage-code transducer, a control unit, and a parameter meter, the output of which is connected to indicators 2.

This device has a low accuracy of the coagulation process due to the insufficient number of informative parameters.

The purpose of the invention is to improve the accuracy of the study.

To this end, a hemocoagulometer, a cuvette for examining a blood sample, a cuvette drive, a transducer connected to it, the output of which is connected to

10 serially connected analog-to-digital converter, blood coagulation parameter measurement units and a display unit, with one output of the control unit connected to

15 by a driven cell, a block for determining the maximum amplitude of the blood coagulation process and a block for determining the maximum speed of the blood coagulation process, and

The output of the analog-digital converter is connected to the input of the block for determining the maximum amplitude of the blood coagulation process, the input of the block for determining the maximum speed

25 of the blood coagulation process is connected to a unit determining the maximum amplitude of the blood coagulation process, the outputs of the units determining the maximum amplitudes and speed of the process.

30, the blood coagulation is connected to the display unit, and the vault control units of the maximum amplitude and speed of the blood coagulation process are connected to the second output of the control unit.

FIG. 1 shows a functional block diagram of a hemocoagulometer; . in fig. 2 is a functional block diagram of gauges of maximum amplitude and speed of the hemocoagulation process. .

A hemocoagulometer contains a cuvette 1 kinematically connected with a drive 2 and a sensor transducer 3, which includes a float immersed in the cuvette and a transducer of the angle of rotation of the float into an electrical signal. Output sensor converter. 3 is connected to the converter 4 of the analog signal to the pulse code (ADC). The output 5 of the A / D converters 4 are connected in parallel with the block 5 for measuring blood coagulation parameters, as well as the block 6 for measuring the maximum amplitude of the blood coagulation process, with which the block 7 for measuring the maximum coagulation rate is connected. The control inputs of the measurement units 5-7 are connected to the control unit 8, to which the drive 2 of the cuvette 1 is also connected. The outputs of the measurement units are connected to the display unit 9. Each of blocks 6 and 7 contains pulse distributors, respectively 10 and 11, counting registers 12 and 13 with summing counting inputs and counting registers 14 and 15 with subtracting counting inputs. The information inputs of registers 12 and 14 are connected to the outputs of the distributor 10, registers 13 and 15 - to the outputs of the distributor 11. The counting registers are connected bitwise 12 from 14, 13 and 15, and the bit enable inputs of the counting registers 14 and 15 are connected to the bus Reset (clock signal) of control block 4. In addition, registers 14 and 15 have feedback to the distributors 10 and 11, respectively. The output of block 10 (11) for determining the maximum speed (V) is the output of register 13, and the output of register 12 is connected to the indicator of maximum amplitude (A) of display unit 9.

Hemocoagulometer works as follows.

A blood sample is placed in cuvette 1 where the float of the transducer 3 is immersed (Fig. 1). At intervals determined by control unit 8 (typically 8-10 s), actuator 2 informs the cuvette rotational oscillations that are transmitted through a blood sample to the float of transducer 3, at the output of which a periodic signal appears that is proportional to the rheological properties

blood. The transducer 4, this signal turns into a pulse code, which enters the inputs of the blocks 5, where taking into account the clock signals from the bus. Resetting the control unit 8 in a known manner converts to the blood coagulation parameters, which go to the corresponding display indicators 9.

Pulse Code and Clock

The 0 signal Reset also goes to the inputs of the maximum amplitude measurement unit b, which works in conjunction with the maximum folding rate measurement unit 7 in the following order.

The initial state of registers 12-15 (Fig. 2) is zeros in all bits, and the feedback between registers with deducting counters

 inputs (14 and 15) and distributors (10 and 11) ensure the passage of pulses from the distributors either to the inputs of these registers only, if their contents are different from zero, or only to the inputs of registers 12

and 13 otherwise. The gauges take into account that the coagulation process is a monotonically increasing function from zero to maximum.

The first series of pulses passes

0 through the distributor 10 into the register 12. The control pulse, before the next pulse train is received, overwrites the first number into the register 14 from the register 12

5 without erasing the information in the latter. The next series of pulses passes through the distributor 10 into register 14, decreasing its contents to zero by each pulse, after which the remaining number of pulses passes into register 12 and is added to the recorded first number, forming the second number of pulses. With the next reset signal, this number is overwritten in register 14, and so on.

up to the maximum number. In this case, in the circuit between registers 10 and 12 each time passes the number of pulses, which is the difference between the next and the previous

a series of pulses, and in register 12 is always written the value of the largest amplitude. The decrease in the intensity of the coagulation process, i.e. the amplitude decrease and the arrival to the distributor 10 of a smaller number of pulses no longer change the register 12 contained. Thus, the block b extracts the maximum amplitude and contains information at each step

0 about the difference of the amplitudes in the form of the number of pulses. These pulses are fed to the input of block 7, where their conversion occurs in a similar sequence: overwriting from the register

5 13 into register 15, subtracting from register 15 zero, summing the remainder with the contents of register 13. Then in register 13, the largest amplitude difference is always the largest, which carries information about the maximum folding rate and transmits it to the indicator of this parameter of the display unit 9.

Thus, the proposed hemocoagulometer automatically determines the new parameter of the coagulation process — the maximum speed, which additionally expands the functionality of the device and allows a hemocoagulation process to be studied with great accuracy.

Claims (2)

1. USSR author's certificate number 513686, cl. L 61 V 5/14, 1974. 2.Biomatic 1,000. Prospect Laboued, Germany, 1974 (prototype).