SU910654A1 - Process for producing 7-dehydrocholesterol benzoate - Google Patents
Process for producing 7-dehydrocholesterol benzoate Download PDFInfo
- Publication number
- SU910654A1 SU910654A1 SU802967263A SU2967263A SU910654A1 SU 910654 A1 SU910654 A1 SU 910654A1 SU 802967263 A SU802967263 A SU 802967263A SU 2967263 A SU2967263 A SU 2967263A SU 910654 A1 SU910654 A1 SU 910654A1
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- SU
- USSR - Soviet Union
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- benzoate
- mol
- producing
- dehydrocholesterol
- picoline
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
1one
Изобретение относитсй к усоверЯиенствованному способу получени бензоата 7 дегидрохолестерина-промежуточного продукта в ринтезе витамина Д .The invention relates to an improved method for the preparation of benzoate 7 of the dehydrocholesterol intermediate product in vitamin D Dint.
Известен способ получени бензоата 7-дегидрохолестерина путем дегидробромировани бензоата 7-бромхолестерина с помсндью органических или неорганических оснований ГИ. A known method for producing 7-dehydrocholesterol benzoate by dehydrobrominating 7-bromholesterol benzoate with an organic or inorganic GI base.
Недостатком такого способа вл етс образование большого количества побочных продуктов и вследствие этого невысокий выход продукта (не более 55%).The disadvantage of this method is the formation of a large amount of by-products and, consequently, a low yield of the product (no more than 55%).
Наиболее близким к предлагаемому способу вл етс известный способ получени бензоата 7-дегидрохолестерина путем дегидробромировани бензоата 7-бромхолестерина с помощью двууглекислого натри в присутствии каталитических количеств 1-пиколина (0,05-0,2 моль) в растворе кип щего ксилола с последующим выделением це- .The closest to the proposed method is the known method for producing 7-dehydrocholesterol benzoate by dehydrobroming 7-bromholesterol benzoate with sodium bicarbonate in the presence of catalytic amounts of 1-picoline (0.05-0.2 mol) in boiling xylene solution, followed by separation of -.
левого продукта из ксилольного фильтрата Г2 .left product of the xylene filtrate G2.
Выход бензоата 7-Двгидрохолестерина 60-62%. Содержание вещества в целевых продуктах.90-93,0%.The output of benzoate 7-Dvhydrocholesterol 60-62%. The content of the substance in the target products. 90-93,0%.
Цель изобретени - повышение выхода и качества целевого продукта.The purpose of the invention is to increase the yield and quality of the target product.
Цель изобретени достигаетс тем, что при получении бензоата 7-дегидрохолестерина путем дегидробромиро10 ваии бензоата 7-брбмхолестерина с помощью двууглекислого натри в присутствии d-пиколина в кип щем ксилоле процесс провод т в присутствии каталатических количеств дибензо-1815 -краун-6-эфира.The purpose of the invention is achieved by the fact that when producing 7-dehydrocholesterol benzoate by dehydrobromide of 7-brbmcholesterol benzoate using sodium bicarbonate in the presence of d-picoline in boiling xylene, the process is carried out in the presence of catalatic amounts of dibenzo-1815 -crown-6-ether.
Процесс предпочтительно провод т при следующем соотношении реагентов: 0,2-0,5 моль dL-пиколина, 0,1-0,2 моль дибензо-18-краун-6-эфира, 5-7 моль The process is preferably carried out in the following ratio of reagents: 0.2-0.5 mol of dL-picoline, 0.1-0.2 mol of dibenzo-18-crown-6-ether, 5-7 mol
20 двууглекислого натри на 1 моль бензоата 7-бромхолестерина.20 sodium bicarbonate per 1 mole of 7-bromholesterol benzoate.
Преимуществом предлагаемого способа вл етс повышение выхода целевоThe advantage of the proposed method is to increase the yield of the target
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU802967263A SU910654A1 (en) | 1980-07-31 | 1980-07-31 | Process for producing 7-dehydrocholesterol benzoate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU802967263A SU910654A1 (en) | 1980-07-31 | 1980-07-31 | Process for producing 7-dehydrocholesterol benzoate |
Publications (1)
Publication Number | Publication Date |
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SU910654A1 true SU910654A1 (en) | 1982-03-07 |
Family
ID=20912325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SU802967263A SU910654A1 (en) | 1980-07-31 | 1980-07-31 | Process for producing 7-dehydrocholesterol benzoate |
Country Status (1)
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SU (1) | SU910654A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101486748B (en) * | 2008-01-15 | 2011-11-02 | 浙江新和成股份有限公司 | Preparation method of preparation of 5,7-diene cholesterol |
-
1980
- 1980-07-31 SU SU802967263A patent/SU910654A1/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101486748B (en) * | 2008-01-15 | 2011-11-02 | 浙江新和成股份有限公司 | Preparation method of preparation of 5,7-diene cholesterol |
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