SU775694A1 - Method of diagnosis of systematic lupus erythematosus - Google Patents
Method of diagnosis of systematic lupus erythematosus Download PDFInfo
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- SU775694A1 SU775694A1 SU782664851A SU2664851A SU775694A1 SU 775694 A1 SU775694 A1 SU 775694A1 SU 782664851 A SU782664851 A SU 782664851A SU 2664851 A SU2664851 A SU 2664851A SU 775694 A1 SU775694 A1 SU 775694A1
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- USSR - Soviet Union
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- lupus erythematosus
- lymphocytes
- diagnosis
- activity
- cells
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Description
(54) СПОСОБ ДИАГНОСТИКИ СИСТЕМНОЙ КРАСНОЙ ВО.ПЧАНКИ(54) METHOD OF DIAGNOSTICS OF SYSTEM RED VO.
Изобретение относитс к области медицины, а именно педиатрии.This invention relates to the field of medicine, namely pediatrics.
Известен способ диагностики системной красной волчанки путем подсчета 5 в крови розеткообразующих Т и В лимфоцитов l.A known method for the diagnosis of systemic lupus erythematosus by counting 5 in the blood of rosette-forming T and B lymphocytes l.
Однако известный способ не позвол ет определить сте.пень активности заболевани .10However, the known method does not allow to determine the degree of disease activity .10
Целью изобретени вл етс определение степени активности заболевани .The aim of the invention is to determine the degree of activity of the disease.
Эта цель достигаетс тем, что подсчитывают количество высокоаффинных лимфоцитов, прикрепивших 16 и более |5 эритроцитов, и при величине 2,5 - 5,0% диагностируют минимальную, 5 - 8% умеренную , а 8 - 15% - высокую степень активности системной красной волчанки.20This goal is achieved by counting the number of high-affinity lymphocytes attached 16 and more | 5 erythrocytes, and with a value of 2.5-5.0% diagnose a minimum, 5-8% moderate, and 8-15% a high degree of systemic red lupus
Способ осуществл ют следующим образом.The method is carried out as follows.
Лимфоциты из периферической крови выдел ют по известной методике в градиенте фико.пл-уротраста. Дл получе- 25 ни Т-клеток к лимфоцитам добавл ют взвесь эритроцитов барана, дл получени В-клеток - эритроциты быка, сенсибилизированные антителами и комплемен том. Готов т мазки,в которых ЗОLymphocytes from peripheral blood were isolated by a known technique in a gradient of a phyko.pl-urostras. To obtain 25 T cells, a sheep erythrocyte suspension is added to the lymphocytes; to obtain B cells, bovine erythrocytes, sensitized with antibodies and complement, are obtained. Prepared t strokes in which ZOR
среди розеткообразующих Т- и В-клеток определ ют процент высокоаффинных лимфоцитов, т;е. прикрепивших 16 и более эритроцитов. При наличии последних в количестве менее 5% к общему числу роэеткообразующих клеток диагностируют минимальную степень активности, 5-8% - умеренную и более 8% - высокую степень активности, что служит основанием дл назначени патогенетического лечени . Данный способ дает возможность на основании анализа адгезивной способности клеток вы вл ть число функционально активных лимфоцитов в попул ции Ти В-клеток.among the rosetting T and B cells, the percentage of high affinity lymphocytes is determined, i; e. attached 16 or more red blood cells. If the latter are present in an amount of less than 5% of the total number of rRNA cells, a minimal degree of activity is diagnosed, 5-8% is moderate, and more than 8% is a high degree of activity, which serves as the basis for prescribing pathogenetic treatment. This method makes it possible, based on an analysis of the adhesion ability of cells, to reveal the number of functionally active lymphocytes in a population of Ti B cells.
Пример. Больна Г. поступила в клинику по поводу системной красной волчанки дл решени вопроса об активности заболевани и продолжени или отмены лечени . При поступлении отсутствовгши выраженные клинические признаки активности заболевани , отмечены лишь артралгии и умеренные влени миокардита. Данные, полученные при предварительном обследовании противоречивы: умеренно ускоренна РОЭ, наличие ЛЕ-клеток, высокий антинуклеарный фактор свидетельExample. Ill G. was admitted to the clinic for systemic lupus erythematosus to decide on the activity of the disease and to continue or cancel treatment. Upon admission, there were no pronounced clinical signs of disease activity, only arthralgia and moderate myocarditis were observed. The data obtained during the preliminary examination are contradictory: moderately accelerated ROE, presence of LU cells, high antinuclear factor witness
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782664851A SU775694A1 (en) | 1978-10-02 | 1978-10-02 | Method of diagnosis of systematic lupus erythematosus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782664851A SU775694A1 (en) | 1978-10-02 | 1978-10-02 | Method of diagnosis of systematic lupus erythematosus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU775694A1 true SU775694A1 (en) | 1980-10-30 |
Family
ID=20785555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU782664851A SU775694A1 (en) | 1978-10-02 | 1978-10-02 | Method of diagnosis of systematic lupus erythematosus |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU775694A1 (en) |
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1978
- 1978-10-02 SU SU782664851A patent/SU775694A1/en active
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