SU651691A3 - Способ получени пептидов или их солей или амидов или сложных бензиловых эфиров - Google Patents
Способ получени пептидов или их солей или амидов или сложных бензиловых эфировInfo
- Publication number
- SU651691A3 SU651691A3 SU731959390A SU1959390A SU651691A3 SU 651691 A3 SU651691 A3 SU 651691A3 SU 731959390 A SU731959390 A SU 731959390A SU 1959390 A SU1959390 A SU 1959390A SU 651691 A3 SU651691 A3 SU 651691A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- liz
- boc
- bok
- mmol
- solution
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 15
- 150000003839 salts Chemical class 0.000 title claims description 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 4
- 238000000034 method Methods 0.000 title description 18
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 125000006239 protecting group Chemical group 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 208000010444 Acidosis Diseases 0.000 claims 1
- 230000007950 acidosis Effects 0.000 claims 1
- 208000026545 acidosis disease Diseases 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 claims 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
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- 238000011095 buffer preparation Methods 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- NKCVNYJQLIWBHK-UHFFFAOYSA-N carbonodiperoxoic acid Chemical compound OOC(=O)OO NKCVNYJQLIWBHK-UHFFFAOYSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- QIRAYNIFEOXSPW-UHFFFAOYSA-N dimepheptanol Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(O)CC)C1=CC=CC=C1 QIRAYNIFEOXSPW-UHFFFAOYSA-N 0.000 description 1
- 229950004655 dimepheptanol Drugs 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- XDDAORKBJWWYJS-UHFFFAOYSA-N glyphosate Chemical compound OC(=O)CNCP(O)(O)=O XDDAORKBJWWYJS-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- XCVNDBIXFPGMIW-UHFFFAOYSA-N n-ethylpropan-1-amine Chemical compound CCCNCC XCVNDBIXFPGMIW-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- SAALQYKUFCIMHR-UHFFFAOYSA-N propan-2-ol;2-propan-2-yloxypropane Chemical compound CC(C)O.CC(C)OC(C)C SAALQYKUFCIMHR-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 235000012045 salad Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- BQFFOUQBTAMINL-UHFFFAOYSA-N tert-butyl 2-methoxybenzoate Chemical compound COC1=CC=CC=C1C(=O)OC(C)(C)C BQFFOUQBTAMINL-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- DRDVJQOGFWAVLH-UHFFFAOYSA-N tert-butyl n-hydroxycarbamate Chemical compound CC(C)(C)OC(=O)NO DRDVJQOGFWAVLH-UHFFFAOYSA-N 0.000 description 1
- 239000012414 tert-butyl nitrite Substances 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 108010038745 tryptophylglycine Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HURI481A HU167360B (OSRAM) | 1972-08-25 | 1972-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU651691A3 true SU651691A3 (ru) | 1979-03-05 |
Family
ID=11000902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU731959390A SU651691A3 (ru) | 1972-08-25 | 1973-08-24 | Способ получени пептидов или их солей или амидов или сложных бензиловых эфиров |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3862111A (OSRAM) |
| JP (1) | JPS5434731B2 (OSRAM) |
| AT (1) | AT335082B (OSRAM) |
| AU (1) | AU471173B2 (OSRAM) |
| BE (1) | BE804016A (OSRAM) |
| CA (1) | CA1024509A (OSRAM) |
| CH (1) | CH591430A5 (OSRAM) |
| CS (1) | CS172872B2 (OSRAM) |
| DD (1) | DD108746A5 (OSRAM) |
| DE (1) | DE2342862C3 (OSRAM) |
| ES (1) | ES418158A1 (OSRAM) |
| FR (1) | FR2196815B1 (OSRAM) |
| GB (1) | GB1429808A (OSRAM) |
| HU (1) | HU167360B (OSRAM) |
| IL (1) | IL43056A (OSRAM) |
| NL (1) | NL7311592A (OSRAM) |
| RO (1) | RO72481A (OSRAM) |
| SU (1) | SU651691A3 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071510A (en) * | 1974-12-16 | 1978-01-31 | Lars Ake Ingemar Carlsson | Peptides having a high adrenocorticotropic effect and a method of producing the same |
| HU177133B (en) * | 1977-07-18 | 1981-07-28 | Richter Gedeon Vegyeszet | Process for preparing angiotensin ii analogues containing alpha- amino-oxy-acid in position 1 with angiotensin ii antagonist activity |
| IT1204434B (it) * | 1986-01-15 | 1989-03-01 | Alfio Bertolini | Composizioni farmaceutiche comprendenti frammenti di acth per il trattamento terapeutico degli stati di shock e dell'insufficienza respiratoria e cardiocircolatoria |
| US6951947B2 (en) * | 2000-07-13 | 2005-10-04 | The Scripps Research Institute | Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation |
| WO2002028890A1 (en) * | 2000-09-29 | 2002-04-11 | The Scripps Research Institute | Labeled peptides, and processes and intermediates useful for their preparation |
| US7176037B2 (en) | 2000-07-13 | 2007-02-13 | The Scripps Research Institute | Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation |
-
1972
- 1972-08-25 HU HURI481A patent/HU167360B/hu unknown
-
1973
- 1973-08-10 CH CH1154973A patent/CH591430A5/xx not_active IP Right Cessation
- 1973-08-13 AT AT706473A patent/AT335082B/de active
- 1973-08-15 US US388547A patent/US3862111A/en not_active Expired - Lifetime
- 1973-08-15 GB GB3859873A patent/GB1429808A/en not_active Expired
- 1973-08-16 AU AU59291/73A patent/AU471173B2/en not_active Expired
- 1973-08-20 CS CS5842A patent/CS172872B2/cs unknown
- 1973-08-22 DD DD173021A patent/DD108746A5/xx unknown
- 1973-08-22 NL NL7311592A patent/NL7311592A/xx not_active Application Discontinuation
- 1973-08-23 IL IL43056A patent/IL43056A/en unknown
- 1973-08-24 SU SU731959390A patent/SU651691A3/ru active
- 1973-08-24 CA CA179,548A patent/CA1024509A/en not_active Expired
- 1973-08-24 FR FR7330785A patent/FR2196815B1/fr not_active Expired
- 1973-08-24 BE BE134929A patent/BE804016A/xx unknown
- 1973-08-24 DE DE2342862A patent/DE2342862C3/de not_active Expired
- 1973-08-24 JP JP9509473A patent/JPS5434731B2/ja not_active Expired
- 1973-08-24 ES ES418158A patent/ES418158A1/es not_active Expired
- 1973-08-25 RO RO7375881A patent/RO72481A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATA706473A (de) | 1976-06-15 |
| AU5929173A (en) | 1975-02-20 |
| AT335082B (de) | 1977-02-25 |
| US3862111A (en) | 1975-01-21 |
| DE2342862C3 (de) | 1981-01-15 |
| IL43056A (en) | 1976-10-31 |
| JPS5434731B2 (OSRAM) | 1979-10-29 |
| FR2196815A1 (OSRAM) | 1974-03-22 |
| BE804016A (fr) | 1973-12-17 |
| ES418158A1 (es) | 1976-08-01 |
| RO72481A (ro) | 1983-02-01 |
| NL7311592A (OSRAM) | 1974-02-27 |
| DD108746A5 (OSRAM) | 1974-10-05 |
| JPS5040563A (OSRAM) | 1975-04-14 |
| HU167360B (OSRAM) | 1975-09-27 |
| DE2342862A1 (de) | 1974-02-28 |
| AU471173B2 (en) | 1976-04-08 |
| CH591430A5 (OSRAM) | 1977-09-15 |
| GB1429808A (en) | 1976-03-31 |
| IL43056A0 (en) | 1973-11-28 |
| FR2196815B1 (OSRAM) | 1976-10-22 |
| CA1024509A (en) | 1978-01-17 |
| CS172872B2 (OSRAM) | 1977-01-28 |
| DE2342862B2 (de) | 1980-05-08 |
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