SU632686A1 - Method of obtaining esters of a-nitrocinnamic acids - Google Patents
Method of obtaining esters of a-nitrocinnamic acidsInfo
- Publication number
- SU632686A1 SU632686A1 SU772499827A SU2499827A SU632686A1 SU 632686 A1 SU632686 A1 SU 632686A1 SU 772499827 A SU772499827 A SU 772499827A SU 2499827 A SU2499827 A SU 2499827A SU 632686 A1 SU632686 A1 SU 632686A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- acids
- nitrocinnamic
- esters
- acid
- obtaining esters
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
II
Изобретение относитс к способу ролучеви эфиров л-нитрокоричной кислоты исходных продуктов дл синтеза аминокислот.This invention relates to a process for the rolloid and esters of l-nitrocaric acid starting materials for the synthesis of amino acids.
Известен способ получени эфиров л-ннтрокоричной кислоты реакцией зфиров нитроуксуоной кислоты с ароматическими альдегидами в присутствии четыреххлористого титана, тетрагидррфурана и третичного .органического основани ц1 Выход при этом достигает 78%.A known method for the preparation of esters of n-n-crocoric acid by the reaction of nitro -suconic acid esters with aromatic aldehydes in the presence of titanium tetrachloride, tetrahydrrfuran, and a tertiary organic base is 1.
Наиболее близким к изобретению вл етс способ получени эфиров а(, нитрокоричной кислоты взаимодействием эфиров ОС, -нитроуксусной кислоты с основани ми Шиффа соответствующих ароматических альдегидов при в среде уксуснуго ангидрида 2J .Выход целевых продуктов 85-90%.The closest to the invention is a method for producing a (, nitrocoric acid esters by reacting esters of OS, α-nitroacetic acid with Schiff bases of the corresponding aromatic aldehydes with acetic anhydride 2J. The yield of target products is 85-90%.
При этом выделение целевого продукта из смеси с эквимол рным количеством образующегос ацетанилида св зано с трудност ми, и недостаточно высок выход целевого продукта.However, it is difficult to isolate the target product from a mixture with an equimolar amount of acetanilide formed, and the yield of the desired product is not high enough.
Цель изобретени - упрощение технологии процесса, позвол ющее исключить трудоемкую очистку целевого продукта, повышение выхода целевого продукта.The purpose of the invention is to simplify the process technology, which eliminates time-consuming purification of the target product, increasing the yield of the target product.
Поставленна цель достигаетс предлагаелвлм способом получени эфиров ей -нитрокоричных кислот взаимодействием метилового эфира нитроуксусной кислоты с эквимол рным количеством адеталей ароматических альдегидов в уксусном ангидриде при 105-160С.This goal is achieved by a method for the preparation of esters of its-nitrocoric acids by the interaction of nitroacetic acid methyl ester with an equimolar amount of aromatic aldehyde adhesives in acetic anhydride at 105-160 ° C.
Отличительньрю признаками способа по изобретению вл ютс использование в качестве исходного продукта ацеталей ароматических альдегидов и проведение процесса при 105-160 С и эквимол рном соотношении реагентов .Distinctive features of the method according to the invention are the use of acetals of aromatic aldehydes as starting materials and carrying out the process at 105-160 ° C and an equimolar ratio of the reactants.
Способ осуществл ют следующим образом.The method is carried out as follows.
Ацетали, легко образующиес из соответствующих альдегидов, конденсируют с метиловым эфиром нитроуксусной кислоты в присутствии избытка уксусного ангидрида при постепенном повышении температуры от 105 до . npJi этом в течение 5-9 час отгон етс сначала этилацетат , а затем уксусна кислота. В остатке получаютс эфи ал -нитрокоричных кислот. Выход целевого продукта составл ет 95-99% от теоре-. тического.Acetals, which are easily formed from the corresponding aldehydes, are condensed with methyl ester of nitroacetic acid in the presence of an excess of acetic anhydride with a gradual increase in temperature from 105 to. After 5-9 hours, npJi was first distilled off with ethyl acetate, and then acetic acid. The residue gives ester of al-nitrocinnamic acids. The yield of the target product is 95-99% of theorem. Tic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU772499827A SU632686A1 (en) | 1977-06-27 | 1977-06-27 | Method of obtaining esters of a-nitrocinnamic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU772499827A SU632686A1 (en) | 1977-06-27 | 1977-06-27 | Method of obtaining esters of a-nitrocinnamic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU632686A1 true SU632686A1 (en) | 1978-11-15 |
Family
ID=20714779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772499827A SU632686A1 (en) | 1977-06-27 | 1977-06-27 | Method of obtaining esters of a-nitrocinnamic acids |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU632686A1 (en) |
-
1977
- 1977-06-27 SU SU772499827A patent/SU632686A1/en active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2566826C1 (en) | Method of producing 1-palmitoyl-3-acetylglycerine and method of producing 1-palmitoyl-2-linoleoyl-3-acetylglycerine using said compound | |
| SU632686A1 (en) | Method of obtaining esters of a-nitrocinnamic acids | |
| US3957856A (en) | Production of the carboxylic acid of perillyl alcohol | |
| Nagano et al. | A New and Convenient Method for the Synthesis of Dehydroamino Acids Starting from Ethyl N-Boc-and NZ-. ALPHA.-Tosylglycinates and Various Nitro Compounds. | |
| YAMAMOTO et al. | 1, 3-Oxazines and Related Compounds. XIV. Facile Synthesis of 2, 3, 6-Trisubstituted 2, 3-Dihydro-1, 3-oxazine-5-carboxylic Acids and 1, 4-Disubstituted 3-Acyl-β-lactams from Acyl Meldrum's Acids and Schiff Bases | |
| US4360691A (en) | Production of malonic anhydrides and derivatives thereof | |
| JP2010229097A (en) | New oxazolidine derivative, new oxazolidine derivative salt and method for producing optically active compound using the oxazolidine derivative salt as asymmetric organic molecular catalyst | |
| US2698341A (en) | Acidolysis of methylal with carboxylic acid anhydroides | |
| WO1986002065A1 (en) | Process for preparing 1,3-cyclohexanedione derivatives and intermediates therefor | |
| SU1366514A1 (en) | Method of obtaining derivatives of n-aryl-5-arylamido-4,6-dimethylpyridone-2 | |
| US4249015A (en) | Preparation of organic acids and/or esters | |
| CA2027010C (en) | 3-substituted 2-hydroxy-3-formylpropionic esters, the preparation thereof and the use thereof for preparing 3-substituted 3-formylacrylic esters | |
| SU1046240A1 (en) | Process for preparing ethers of beta-alkoxyacrylic or beta-alkoxymethacrylic acid | |
| SU715583A1 (en) | Method of preparing alpha-organosilicon acylals | |
| JP2668435B2 (en) | Cyclopentenone derivatives and their production | |
| JP2001181271A (en) | Method for producing alpha-monoglyceride ketal | |
| SU749825A1 (en) | Method of preparing tert-butyl ester of n-phthalylglycine | |
| SU1105114A3 (en) | Method of obtaining 3,3-dimethylglutaric acid or its esters | |
| SU787410A1 (en) | Method of preparing 2-methyl-2,2'-bidioxacycloclanes-1,3 | |
| HU196947B (en) | Process for production of phenil-acetic-acid-esthers | |
| SU440367A1 (en) | Method for producing aminobenzoic acid esters | |
| SU745893A1 (en) | Method of preparing 2,2-dichloropropionic acid powest aliphatic esters | |
| SU425900A1 (en) | Method of producing complex esters of o) -chloroalkylcarbonic acids | |
| JPS6364416B2 (en) | ||
| SU719996A1 (en) | Method of preparing methyl tricarboxylates |