SU62646A1 - The method of producing propyl nitrite - Google Patents
The method of producing propyl nitriteInfo
- Publication number
- SU62646A1 SU62646A1 SU34A SU34A SU62646A1 SU 62646 A1 SU62646 A1 SU 62646A1 SU 34 A SU34 A SU 34A SU 34 A SU34 A SU 34A SU 62646 A1 SU62646 A1 SU 62646A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- nitrite
- propyl nitrite
- mixture
- water
- producing propyl
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Изобретение относитс к способутюлучепи фармацевтического ирепарата , ирактически примен емого в медицинской ирактике.The invention relates to the method of pharmaceutical preparation, and it is practical in medical practice.
Известный способ получени пропи.тнитрита слагаетс из двух отдельных процессов: приготовлени смеси пропанола, серной кислоты и раствора нитрита натри в воде и ох.маждеии смеси до соответственно низкой темпе)атуры. По этому способ иы.ходы достигаютс око.ю 70% от теоретического.The known method of producing propitol nitrite consists of two separate processes: the preparation of a mixture of propanol, sulfuric acid and a solution of sodium nitrite in water and the cooling of the mixture to a correspondingly low rate. According to this method, yo.khody reach an eye of 70% of theoretical.
Описываемый способ устран ет доиолните.-ьный процесс приготовлени смеси пропанола, серной кислоты и воды, требующий значите.-1ьпой затраты времени и известных расходов па охлаждение смесп до низкой температуры. Кроме того oииcывae ;ып способ дает нозмо кпост1 держать те гпературу на пескол1,ко градусов выше, чем в извсч тных способах. Выходы в данном случае посто нны и достигают от теоретического .The described method eliminates the completion of the process of preparing a mixture of propanol, sulfuric acid and water, which requires a significant amount of time and known expenses for cooling the mixture to a low temperature. In addition, the aea; yp method makes it possible for the nosmo kpast1 to keep those temperatures at a sandstone 1, a degree higher than in conventional methods. Outputs in this case are constant and reach from the theoretical.
Пример. В эмалированный железный аппарат. спабжсн1П11Й мешалкой и рубашкой дл холодильного рассола загружают раствор нитрита натри 12,8 кг в 55 литрах воды и 8 кг пропанола. После доведени температуры смеси до -Ь7° добавл етс техническа серна кислота (уд. веса 1,84) 7,7 кг, разбавленна половинным количеством воды (т. е. 3,8 л) и охлажденна до комнатной температуры. Врем прибавлени серной кислоты определ етс поддерживанием температуры реакционной массы при г7, скоростью пропуска рассола через рубашку аппарата в среднем около 6 час. После расхода всей кислоты продолжают перемешивание еще некоторое врем , пока температура снизитс примерно, градуса на 3. Продукт реакции отстаиваетс NnniyT 20 и верхний слой пропилнитрита отдел ют в делительной воронке известными техническими приемами.Example. In the enameled iron apparatus. Using a stirrer and a jacket for refrigeration brine, a solution of sodium nitrite 12.8 kg in 55 liters of water and 8 kg of propanol is charged. After adjusting the temperature of the mixture to -7 °, technical sulfuric acid (weight: 1.84) 7.7 kg, diluted with half the amount of water (i.e., 3.8 l) and cooled to room temperature, is added. The time of addition of sulfuric acid is determined by maintaining the temperature of the reaction mass at r7, the speed of passing the brine through the jacket of the apparatus, on average, about 6 hours. After all the acid has been consumed, stirring is continued for some time, until the temperature decreases by about 3 degrees. The reaction product is settled with NnniyT 20 and the upper layer of propyl nitrite is separated in a separating funnel using known techniques.
Фракционированием получают фармакопейный пропилнитрит с уд. з. 0,8865. Выход 9150 г, т. е. 77% от теоретического.Pharmacopoeial propyl nitrite with beats is obtained by fractionation. h 0.8865. Output 9150 g, ie, 77% of theoretical.
№ В2646- 2 № В2646- 2
П р е д м е т и з о б р е т е н и PRIORITY AREA
Способ получени нормальпого пропилнитрита, взаимодействием серией кислоты, пропилового спирта и нитрита натри , о т л и ч а ю щ и йс тем, что раствор сериой кислоты приливаетс к смеси нормального пропанола, нитрита натри и воды при комнатной температуре.The process for the preparation of normal propyl nitrite, by the interaction of a series of acid, propyl alcohol and sodium nitrite, is carried out in that the solution of seric acid is added to a mixture of normal propanol, sodium nitrite and water at room temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU34A SU62646A1 (en) | 1942-05-14 | 1942-05-14 | The method of producing propyl nitrite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU34A SU62646A1 (en) | 1942-05-14 | 1942-05-14 | The method of producing propyl nitrite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU62646A1 true SU62646A1 (en) | 1942-11-30 |
Family
ID=48243763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU34A SU62646A1 (en) | 1942-05-14 | 1942-05-14 | The method of producing propyl nitrite |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU62646A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2553391C2 (en) * | 2010-04-15 | 2015-06-10 | Чайна Петролеум & Кемикал Корпорейшн | Method for producing c1-c4 alkyl nitrile |
-
1942
- 1942-05-14 SU SU34A patent/SU62646A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2553391C2 (en) * | 2010-04-15 | 2015-06-10 | Чайна Петролеум & Кемикал Корпорейшн | Method for producing c1-c4 alkyl nitrile |
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