SU539432A1 - Method for racemizing optically active aminoacids - Google Patents

Description

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noii resin with and. myodiastatic) (j- |) ynii; Mii in copper form, a product is obtained, the combination of copper in which is only 0.014%, which is determined by means of flame photometry.

The resin can be used many times for the reaction of racemization of the same ampokielote without additional regimen.

According to the proposed method, the following amipocslots are used: /) - alapip, Dorleytspn p /} - serine.

PRPMER 1. 2 ml of smo.ty containing quaternary ammopium groups neutralize 0.04 g of salicylic aldehyde (3.0-10 mol / l). Add 0.5 ml amphoteropic emols with complex-like properties in copper form n 0.27 g (0.3 mol / l) /} - alapipa in 10 ml of water.

The laugh is heated at 65 ° C for 1 hour. The resin is then filtered and the solution is evaporated. The degree of racemization is controlled by the molecule. Under these conditions, racemization takes place by 100%.

Example 2. It differs from Example 1 in that instead of saldetal aldegda, it is used) nthrosalpaldehyde and reactively carried out at 75 ° C. Ran.emizatsiya runs at 100%.

Example 3. It differs from Example 1 in that bromealicylic aldehyde is used instead of salicylic aldegpd. Racemization takes place pas 100%.

PRPME 4. 2 ml of the resin, containing quaternary ammonium groups, neutralized 0.06 g of bromealpcyl aldeg.cha (3.0-10 2 mol / l). 0.27 g (0.3 mol / l) of O-alania is added to 10 ml of water.

The mixture is heated at 50 ° C and with stirring for 1 hour. Then, the resin is filtered and the solution is sterilized. The degree of racemization is determined by GLC.

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Under these conditions, racemization takes 60%.

Example 5. It differs from Example 1 in that, instead of D-alappa, racemized / 3-porleppn. Race compaction is 100%:

Example (). Differs from Example 1 in that racemize / 3-aronp instead of / -alanip. Under the same conditions, racemization is 80%.

Example 7. 2 ml of the resin, stored J, its fourth ammopium group, peutralized 0.04 g of saline a.1 h1 and placed in a thermostatically controlled column. Add 0.5 ml of amphoteropic resin with complex-type properties in the copper form p 0, g (0.3 mol / l) D-alaiin in 10 ml of water. The microaeron pumped the solution of ampoxyacid through the column for 1 hour. The temperature in the jacket of the column was 65 ° C. Then the solution is drained, evaporated and analyzed by GLC. In these conditions, racemization is 100% complete.

F O r M u l a p 3 o b e t e i u

Comparatively interpreting optically active amino acids in aqueous solution when heated in n) istststii organic resins based on sopo; gimer divipelapzol and styrene, tl and h and n and tel, that, with the aim of h1roi1, epi iiponecca, as Divipilbzpol and etirol copolymer resins use an ion exchange resin containing quaternary amopium groups in the OD form, to which is added the aldehyde or its derivative, or a mixture with a base resin containing the fourth ammonium groups in the OH form and the gum based resins, containing resins containing Quaternary ammonium groups in the OH form and resins on the basis of the resin. a and styrene LGedpoy form.

Claims (1)

The method of racemization of optically active 30 amino acids in an aqueous solution when heated in the presence of organic resins based on a divinylbenzene copolymer and styrene, characterized in that, in order to simplify the process, an ion-exchange resin containing quaternary ammonium is used as a resin based on a 35 based copolymer of divinylbenzene and styrene groups in the OH ^- form, to which was added salicylaldehyde or its derivatives, or a mixture of 40 ion exchange resin containing quaternary ammonium groups in the OH form and divinyl-based resin styrene in the form of copper.