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(4-пиридил)-пропен-1-ола-3 на вз тый 4-виыилпири ин 46,7%. Пример 4. Провод т реакцию, как в првмере 3, использу Б .качестве вторичного амшш 0,0013 г пиперидина. Выход целевого продукта 47,5 7о при 100%-иой конверсии 4-винилпиридина. Предмет изобретени 1. Способ получени 2-(4-пиридил)-пропбн-1-ола-3 , отличающийс тем, что, с целью упрощени процесса и повышени степени чистоты продукта, 4-винилпир(ИДИн подвергают взаимодейст1вию с формальдегидом при повышенной температуре в присутствии каталитических количеств (Вторичных аминов с пОСледуюш,им выделением целевого продукта известными приемами. 2. Способ по п. 1, отличающийс тем, что процесс ведут при 130-200° С.(4-pyridyl) -propen-1-ola-3 for 4-viyylpyri and 46.7%. Example 4. The reaction was carried out as in Example 3, using B. A quality of secondary amyloch 0.0013 g of piperidine. The yield of the target product is 47.5 7 ° at 100% conversion of 4-vinylpyridine. The subject matter of the invention is 1. A method for producing 2- (4-pyridyl) -propbn-1-ola-3, characterized in that, in order to simplify the process and increase the purity of the product, 4-vinylpyr (IDIN is reacted with the formaldehyde at an elevated temperature the presence of catalytic amounts (Secondary amines with further development, by isolating the target product by known methods. 2. The method of claim 1, wherein the process is carried out at 130-200 ° C.
SU1924632A1973-05-211973-05-21
The method of obtaining 2- (4-pyridyl) propen-1-ol-3
SU479764A1
(en)
A method for producing quinoline alkyl derivatives. The invention relates to a method for producing quinoline alkyl derivatives of the general formula where RI is alkyl; R2 is hydrogen or alkyl, and alkyl RI contains one carbon atom more than alkyl Rs, which are used in the chemical industry. Known methods for producing alkyl derivatives of quinoline by reacting anilines with carbonyl-containing compounds (for example, aldehydes, ketones) in the presence of various condensates , their and yush oxide, their agents require the use of hard-to-reach starting materials. The purpose of the invention — to improve the process technology — is achieved by the fact that a mixture of nitrobenzene and aliphatic alcohol of the general formula ROH, where R is Cz — Ce-alkyl, passed through an industrial vanadium catalyst (B-3) at 320–360 ° C, followed by isolation of the target product by known methods.5 Irimer 1. Synthesis of 2-methylquinoline (quinaldine). A mixture of 13 ml of nitrobenzene and 14 ml of ethyl alcohol is passed through a B-3 vanadium catalyst heated to 320 ° C, but partially activated by hydrogen for 1 hour at 350–380 ° C. An oily layer is separated from the catalyzate consisting of two layers, distilled, and 4.6 ml (35%) quinaldine are obtained, i.e. bale. 246-249 ° C, so pl. picra-15 and 191–192 ° C. Found,%: N 9.92; 10,13.CioHgN. Calculated,%: N 9.79. In Examples 2-5, tabulated, 20 experiments were carried out, as in Example 1, using in each case 13 ml of nitrobenzene and different amounts of alcohols and skips the reaction mixture is heated to a certain temperature vanadium catalyst B-3. 25 The results are shown in the table.