SU557753A3 - The method of obtaining-penicillamine - Google Patents
The method of obtaining-penicillamineInfo
- Publication number
- SU557753A3 SU557753A3 SU2121914A SU2121914A SU557753A3 SU 557753 A3 SU557753 A3 SU 557753A3 SU 2121914 A SU2121914 A SU 2121914A SU 2121914 A SU2121914 A SU 2121914A SU 557753 A3 SU557753 A3 SU 557753A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- penicillamine
- carried out
- obtaining
- solvent
- acid
- Prior art date
Links
Description
тнаэолидиновое кольцо бензюшенилловой кислоты. Образующийс ги разон рвстворим в гор чем растйоритепе , а D пеюндалламин выдел етс в кристаллической форме.thaolidine ring of benzushenyl acid. The resulting gaseous solution is soluble in the hot melter and D peundallamine D is isolated in crystalline form.
Протдасс осуществл ют следующим образом.The procedure is carried out as follows.
Смесь бензилпенйлповой кислоты и фенилгвдразиш в растворгггеле нагревают 2 час пру 70-140°С. Полученный кристаллический D пеницилламин отфильтровывают от гор чей реакциейн А смеси в промьшают гор чим абсолютным этиловым спиртом.A mixture of benzylpenic acid and phenylgddisish in solution gel is heated for 2 hours at a pressure of 70-140 ° C. The obtained crystalline penicillamine D is filtered off from the hot reaction A in the mixture and then washed with hot absolute ethanol.
Пример. Смесь 20 г (0,065 моль) бензилпеиилловой кислоты, 21 г (0,194 моль) феннлпцфаЗИНЕ н 60 мл абсо.шотного эталового спирта иеремешивают 2 час при кип чении. Гор чую реакционную смесь ф 1лырзют, кристаллический D - пеннцилламин промьшают на фильтре 30 мл гор чего абсолютного этилового сгафта в получают 7,5 г D -пеницилламина (77,5%). Содерношие основного вещества 98,5%; -«l -60,7.Example. A mixture of 20 g (0.065 mol) of benzyl peiyl acid, 21 g (0.194 mol) of fennlpcphaZINE and 60 ml of abstalut alcohol was stirred at reflux for 2 h. A hot reaction mixture, 1Lyrzyut, crystalline D-penncylamine, is washed on the filter with 30 ml of hot absolute ethyl sgafat, 7.5 g of D-penicillamine (77.5%) are obtained. Some main substance 98.5%; - “l -60,7.
В аналогичных услови х при использовании BNKCTO абсолнгаюго этилового спирта другого растворител получают D пеницилламин, характерисIHKH которого претедетш в таблице.Under similar conditions, when BNKCTO is used with the absolute ethanol of another solvent, D penicillamine is obtained, the IHKH of which is listed in the table.
Claims (3)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YU97374A YU97374A (en) | 1974-04-08 | 1974-04-08 | Process for preparing d-penicillamine |
Publications (1)
Publication Number | Publication Date |
---|---|
SU557753A3 true SU557753A3 (en) | 1977-05-05 |
Family
ID=25552228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU2121914A SU557753A3 (en) | 1974-04-08 | 1975-04-07 | The method of obtaining-penicillamine |
Country Status (5)
Country | Link |
---|---|
AT (1) | AT337150B (en) |
CH (1) | CH598210A5 (en) |
DE (1) | DE2512608C2 (en) |
SU (1) | SU557753A3 (en) |
YU (1) | YU97374A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1523090A (en) * | 1976-07-10 | 1978-08-31 | Taisho Pharmaceutical Co Ltd | Method for preparing d-pencilillamine and salts thereof |
CN102627592A (en) * | 2012-03-16 | 2012-08-08 | 石家庄学院 | Preparation method of high-purity D-penicillamine |
-
1974
- 1974-04-08 YU YU97374A patent/YU97374A/en unknown
-
1975
- 1975-03-19 CH CH351675A patent/CH598210A5/xx not_active IP Right Cessation
- 1975-03-21 DE DE19752512608 patent/DE2512608C2/en not_active Expired
- 1975-03-27 AT AT234875A patent/AT337150B/en not_active IP Right Cessation
- 1975-04-07 SU SU2121914A patent/SU557753A3/en active
Also Published As
Publication number | Publication date |
---|---|
CH598210A5 (en) | 1978-04-28 |
ATA234875A (en) | 1976-10-15 |
DE2512608C2 (en) | 1982-10-21 |
AT337150B (en) | 1977-06-10 |
YU97374A (en) | 1980-04-30 |
DE2512608A1 (en) | 1975-10-23 |
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