SU557753A3 - The method of obtaining-penicillamine - Google Patents

The method of obtaining-penicillamine

Info

Publication number
SU557753A3
SU557753A3 SU2121914A SU2121914A SU557753A3 SU 557753 A3 SU557753 A3 SU 557753A3 SU 2121914 A SU2121914 A SU 2121914A SU 2121914 A SU2121914 A SU 2121914A SU 557753 A3 SU557753 A3 SU 557753A3
Authority
SU
USSR - Soviet Union
Prior art keywords
penicillamine
carried out
obtaining
solvent
acid
Prior art date
Application number
SU2121914A
Other languages
Russian (ru)
Inventor
Гашперт Бранко
Херак Йюрай
Original Assignee
Плива Фармацойтише Унд Хемише Фабрик (Инопредприятие)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Плива Фармацойтише Унд Хемише Фабрик (Инопредприятие) filed Critical Плива Фармацойтише Унд Хемише Фабрик (Инопредприятие)
Application granted granted Critical
Publication of SU557753A3 publication Critical patent/SU557753A3/en

Links

Description

тнаэолидиновое кольцо бензюшенилловой кислоты. Образующийс  ги разон рвстворим в гор чем растйоритепе , а D пеюндалламин выдел етс  в кристаллической форме.thaolidine ring of benzushenyl acid. The resulting gaseous solution is soluble in the hot melter and D peundallamine D is isolated in crystalline form.

Протдасс осуществл ют следующим образом.The procedure is carried out as follows.

Смесь бензилпенйлповой кислоты и фенилгвдразиш в растворгггеле нагревают 2 час пру 70-140°С. Полученный кристаллический D пеницилламин отфильтровывают от гор чей реакциейн А смеси в промьшают гор чим абсолютным этиловым спиртом.A mixture of benzylpenic acid and phenylgddisish in solution gel is heated for 2 hours at a pressure of 70-140 ° C. The obtained crystalline penicillamine D is filtered off from the hot reaction A in the mixture and then washed with hot absolute ethanol.

Пример. Смесь 20 г (0,065 моль) бензилпеиилловой кислоты, 21 г (0,194 моль) феннлпцфаЗИНЕ н 60 мл абсо.шотного эталового спирта иеремешивают 2 час при кип чении. Гор чую реакционную смесь ф 1лырзют, кристаллический D - пеннцилламин промьшают на фильтре 30 мл гор чего абсолютного этилового сгафта в получают 7,5 г D -пеницилламина (77,5%). Содерношие основного вещества 98,5%; -«l -60,7.Example. A mixture of 20 g (0.065 mol) of benzyl peiyl acid, 21 g (0.194 mol) of fennlpcphaZINE and 60 ml of abstalut alcohol was stirred at reflux for 2 h. A hot reaction mixture, 1Lyrzyut, crystalline D-penncylamine, is washed on the filter with 30 ml of hot absolute ethyl sgafat, 7.5 g of D-penicillamine (77.5%) are obtained. Some main substance 98.5%; - “l -60,7.

В аналогичных услови х при использовании BNKCTO абсолнгаюго этилового спирта другого растворител  получают D пеницилламин, характерисIHKH которого претедетш в таблице.Under similar conditions, when BNKCTO is used with the absolute ethanol of another solvent, D penicillamine is obtained, the IHKH of which is listed in the table.

Claims (3)

1.Способ получени  D пеницшшамнв расщеплением бензилпенилловс кислоты при нагревани , отличающийс  тем, что, с цепыо увеличени  выхода конечного продукта, расщепление провод т фешшгидразином в безвощюм растворителе и полученный KpHCTajunrteooift продукт отфильтровывают и промывают абсолютньпм этиловым спиртом.1. A method for producing D penicillins by splitting benzylpenyl acid with heating, characterized in that with a chain of increase in the yield of the final product, the cleavage is carried out with feshhydrazine in a solvent free solvent and the product obtained with KpHCTajunrteooift is filtered and washed with absolute alcohol. 2.Способ по п. 1, отличающийс  тем, что в качестве растворител  примен ют абсолютный2. A method according to claim 1, characterized in that the solvent used is absolute этиловый эфир, бензол, толуол или К(Я1ЛОЛ.ethyl ether, benzene, toluene or K (YALOL. 3.Способ по п. 1, отличающийс  тем,что процесс ведут при 70-140° С.3. The method according to claim 1, characterized in that the process is carried out at 70-140 ° C.
SU2121914A 1974-04-08 1975-04-07 The method of obtaining-penicillamine SU557753A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU97374A YU97374A (en) 1974-04-08 1974-04-08 Process for preparing d-penicillamine

Publications (1)

Publication Number Publication Date
SU557753A3 true SU557753A3 (en) 1977-05-05

Family

ID=25552228

Family Applications (1)

Application Number Title Priority Date Filing Date
SU2121914A SU557753A3 (en) 1974-04-08 1975-04-07 The method of obtaining-penicillamine

Country Status (5)

Country Link
AT (1) AT337150B (en)
CH (1) CH598210A5 (en)
DE (1) DE2512608C2 (en)
SU (1) SU557753A3 (en)
YU (1) YU97374A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523090A (en) * 1976-07-10 1978-08-31 Taisho Pharmaceutical Co Ltd Method for preparing d-pencilillamine and salts thereof
CN102627592A (en) * 2012-03-16 2012-08-08 石家庄学院 Preparation method of high-purity D-penicillamine

Also Published As

Publication number Publication date
CH598210A5 (en) 1978-04-28
ATA234875A (en) 1976-10-15
DE2512608C2 (en) 1982-10-21
AT337150B (en) 1977-06-10
YU97374A (en) 1980-04-30
DE2512608A1 (en) 1975-10-23

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