SU462814A1 - Method of producing methylcyclopropyl ketone - Google Patents

Method of producing methylcyclopropyl ketone

Info

Publication number
SU462814A1
SU462814A1 SU1873704A SU1873704A SU462814A1 SU 462814 A1 SU462814 A1 SU 462814A1 SU 1873704 A SU1873704 A SU 1873704A SU 1873704 A SU1873704 A SU 1873704A SU 462814 A1 SU462814 A1 SU 462814A1
Authority
SU
USSR - Soviet Union
Prior art keywords
producing
target product
ketone
methylcyclopropyl ketone
methyl
Prior art date
Application number
SU1873704A
Other languages
Russian (ru)
Inventor
Роберт Аветисович Караханов
Борис Борисович Блинов
Валентина Алексеевна Зефирова
Original Assignee
Институт Органической Химии Им.Н.Д. Зелинского
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Органической Химии Им.Н.Д. Зелинского filed Critical Институт Органической Химии Им.Н.Д. Зелинского
Priority to SU1873704A priority Critical patent/SU462814A1/en
Application granted granted Critical
Publication of SU462814A1 publication Critical patent/SU462814A1/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

1one

Изобретение относитс  к способу получени  метилциклопропилкетона, используемого в тонком органическом синтезе.This invention relates to a method for producing methylcyclopropyl ketone used in fine organic synthesis.

Известен способ получени  метилциклопропилкетона изомеризацией 2-метил-4,5-дигидрофурана при 475-500°С с последующим выделением целевого продукта известными приемами .A known method for producing methylcyclopropyl ketone by isomerization of 2-methyl-4,5-dihydrofuran at 475-500 ° C, followed by isolation of the target product by known methods.

Выход целевого продукта 32%.The yield of the target product is 32%.

Недостатком известного способа  вл етс  низкий выход целевого продукта и проведение процесса при высоких температурах.The disadvantage of this method is the low yield of the target product and the process at high temperatures.

С целью повышени  выхода целевого продукта и упрощени  процесса предлагаетс  использовать 2-метил-4,5-дигидрофуран в виде насыщенного пара в смеси с инертным газом и вести процесс в присутствии окиси алюмини  в качестве катализатора, предпочтительно при 300-350°С.In order to increase the yield of the target product and simplify the process, it is proposed to use 2-methyl-4,5-dihydrofuran in the form of saturated steam mixed with an inert gas and conduct the process in the presence of alumina as a catalyst, preferably at 300-350 ° C.

Выход целевого продукта 85%.The yield of the target product is 85%.

И р и м е р. Кварцевую трубку (длина 400 мм, диаметр 20 мм) заполн ют 25 г промышленной окиси алюмини  и помещают в электрическую печь с автоматической регулировкой температуры.And p and meer. A quartz tube (length 400 mm, diameter 20 mm) is filled with 25 g of industrial alumina and placed in an electric oven with automatic temperature control.

50 г исходного дигидросильвана, т. кип. 79-80°С/750 мм; г о 1,4301; 0,9039, подают на катализатор в виде насыщенного пара50 g of the original dihydrosilvana, t. Kip. 79-80 ° С / 750 mm; r about 1.4301; 0.9039, served on the catalyst in the form of saturated steam

22

в Токе азота в течение 2,5 час. Давление 1 атм, температура 310°С. В приемнике с вод ным охлаждением собирают 47 г (95%) катализата , при ректификации которого с выходом 85% выдел ют метилциклопропилкетон, т. кип.in the current of nitrogen for 2.5 hours. Pressure is 1 atm, temperature is 310 ° C. 47 g (95%) of catalyzate is collected in a water-cooled receiver, the distillation of which gives off 85% to give methylcyclopropyl ketone, m.p.

110°С/7бО мм; По 1,4252; 4 0,8984; т. пл. семикарбазона 120°С. Конверси  98%. Из катализата также выдел ют метилпропилкетон (3-4%), тетрагидросильван (4%), сильван (6%) и легкокип щие вещества (3%).110 ° C / 7 mm; 1.4252 each; 4 0.8984; m.p. semicarbazone 120 ° C. Conversion 98%. Methylpropyl ketone (3–4%), tetrahydrosilane (4%), sylvan (6%), and low-boiling substances (3%) are also isolated from catalyzate.

Предмет изобретени Subject invention

Claims (2)

1. Способ получени  метилциклопропилкетона изомеризацией 2-метил-4,5-дигидрофурана при повышенной температуре с последующим выделением целевого продукта известными приемами, отличающийс  тем, что, с целью повышени  выхода целевого продукта и упрощени  процесса, используют 2-метил-4,5дигидрофуран в виде насыщенного пара в смеси с инертным газом и процесс ведут в присутствии окиси алюмини  в качестве катализатора .1. A method for producing methylcyclopropyl ketone by isomerization of 2-methyl-4,5-dihydrofuran at elevated temperature followed by separation of the target product by known methods, characterized in that, in order to increase the yield of the target product and simplify the process, 2-methyl-4,5dihydrofuran is used in the form of saturated steam mixed with an inert gas and the process is carried out in the presence of alumina as a catalyst. 2. Способ по п. 1, отличающийс  2. The method according to claim 1, wherein тем, что процесс ведут при 300- 350°С.the fact that the process is carried out at 300-350 ° C.
SU1873704A 1973-01-19 1973-01-19 Method of producing methylcyclopropyl ketone SU462814A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU1873704A SU462814A1 (en) 1973-01-19 1973-01-19 Method of producing methylcyclopropyl ketone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1873704A SU462814A1 (en) 1973-01-19 1973-01-19 Method of producing methylcyclopropyl ketone

Publications (1)

Publication Number Publication Date
SU462814A1 true SU462814A1 (en) 1975-03-05

Family

ID=20539782

Family Applications (1)

Application Number Title Priority Date Filing Date
SU1873704A SU462814A1 (en) 1973-01-19 1973-01-19 Method of producing methylcyclopropyl ketone

Country Status (1)

Country Link
SU (1) SU462814A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106554263A (en) * 2016-11-16 2017-04-05 江苏清泉化学股份有限公司 A kind of preparation method of cyclopropyl methyl ketone

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106554263A (en) * 2016-11-16 2017-04-05 江苏清泉化学股份有限公司 A kind of preparation method of cyclopropyl methyl ketone
CN106554263B (en) * 2016-11-16 2019-11-08 江苏清泉化学股份有限公司 A kind of preparation method of cyclopropyl methyl ketone

Similar Documents

Publication Publication Date Title
Castellino et al. Syntheses of Tetrahydrofuro [2, 3-B] benzofurans: a Synthesis of (.+-.)-aflatoxin B2
SU462814A1 (en) Method of producing methylcyclopropyl ketone
Yamaguchi et al. Synthesis of phenols by polyketide condensation and an efficient synthesis of 3, 5-dioxoalkanoates from amides
SU474966A3 (en) Method for producing diolefinic hydrocarbons
SU123959A1 (en) The method of obtaining vinyl - and phenyldichlorosilanes
RU2152938C1 (en) Method of preparing formyltetrahydropyrans
Crawford Facile synthesis of (+-)-ar-artemisene via olefin metalation
SU657031A1 (en) Method of obtaining selencyclohexane
Onishi et al. SELECTIVE ISOMERIZATION OF 2, 5-DIENONES TO 2, 4-DIENONES WITH NICKEL ACETYLACETONATE CATALYST
SU368210A1 (en) METHOD OF OBTAINING OLEFIN HYDROCARBONS
US3149172A (en) Trans 1-halobutadienes
SU370195A1 (en) USSR Academy of Sciences
SU438631A1 (en) The method of producing isobutylene
SU386896A1 (en) Method of producing octafluorostirol
SU992515A1 (en) Process for preparing 4-methyl-5,6-dihydro-2h-pyran
Sundberg et al. Photochemical deconjugation as a synthetic route to 1, 2, 3, 6-tetrahydropyridine-4-acetic acid esters from. DELTA. 4,. alpha.-piperidine-4-acetic acid esters
SU432142A1 (en) METHOD OF OBTAINING LEPIDIN
SU703519A1 (en) Method of preparing indenes
Chang et al. Vapor-phase Reaction of Monoterpenes Part I. Cyclization of Citronellal to Isopulegol
SU468917A1 (en) The method of obtaining tert.-butylperoxyalkylbenzenesulfonate
SU426987A1 (en) METHOD OF GETTING METHYL CYCLOPENTADIENE
SU379567A1 (en) METHOD FOR OBTAINING DERIVATIVE PERFLUORETHACRYLIC ACID DERIVATIVES .. ACETO ^ C REVIEW, GLA1 ^ 0-T; 1SCHBBIE-L ^ O: T: -
SU389099A1 (en) Method of producing polyfluoroalkenyl (alkyl) halogenesyl
Ikeda et al. SYNTHESIS OF d l-(2 E, 6 Z, 10 E)-CERICERENE FOR ELUCIDATION OF THE PROPOSED STRUCTURE OF CERICEROL-I
US2596102A (en) Process of preparing cyclohexene