SU456808A1 - Способ получени 1- -арабинофуранозилцитозина - Google Patents
Способ получени 1- -арабинофуранозилцитозинаInfo
- Publication number
- SU456808A1 SU456808A1 SU1840153A SU1840153A SU456808A1 SU 456808 A1 SU456808 A1 SU 456808A1 SU 1840153 A SU1840153 A SU 1840153A SU 1840153 A SU1840153 A SU 1840153A SU 456808 A1 SU456808 A1 SU 456808A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- arabinofuranosylcytosine
- vacuo
- cytidine
- evaporated
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 5
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 title description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims description 3
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims description 3
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- ROORDVPLFPIABK-UHFFFAOYSA-N diphenyl carbonate Chemical compound C=1C=CC=CC=1OC(=O)OC1=CC=CC=C1 ROORDVPLFPIABK-UHFFFAOYSA-N 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- -1 diphenyl carbonate Chemical compound 0.000 claims 1
- 159000000011 group IA salts Chemical class 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000000126 substance Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS708471A CS164401B1 (en) | 1971-10-07 | 1971-10-07 | Method of 1-beta-d-arabinofuranosylcytosine's preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU456808A1 true SU456808A1 (ru) | 1975-01-15 |
Family
ID=5419302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1840153A SU456808A1 (ru) | 1971-10-07 | 1972-10-06 | Способ получени 1- -арабинофуранозилцитозина |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS4844271A (enrdf_load_stackoverflow) |
| AU (1) | AU458692B2 (enrdf_load_stackoverflow) |
| CA (1) | CA952901A (enrdf_load_stackoverflow) |
| CS (1) | CS164401B1 (enrdf_load_stackoverflow) |
| DE (1) | DE2234881A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1378408A (enrdf_load_stackoverflow) |
| HU (1) | HU165019B (enrdf_load_stackoverflow) |
| SU (1) | SU456808A1 (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4924676A (enrdf_load_stackoverflow) * | 1972-06-30 | 1974-03-05 | ||
| JPS55165627A (en) * | 1979-06-09 | 1980-12-24 | Pioneer Electronic Corp | Method for diffusing impurity into semiconductor |
| SE8802687D0 (sv) * | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
| MX9702927A (es) * | 1994-10-24 | 1998-04-30 | Genencor Int | L-piranosilnucleosidos. |
| US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
-
1971
- 1971-10-07 CS CS708471A patent/CS164401B1/cs unknown
-
1972
- 1972-07-05 AU AU44242/72A patent/AU458692B2/en not_active Expired
- 1972-07-15 DE DE19722234881 patent/DE2234881A1/de active Pending
- 1972-07-19 GB GB3373072A patent/GB1378408A/en not_active Expired
- 1972-08-04 CA CA148,838A patent/CA952901A/en not_active Expired
- 1972-10-05 HU HUCE000899 patent/HU165019B/hu unknown
- 1972-10-06 SU SU1840153A patent/SU456808A1/ru active
- 1972-10-07 JP JP10033372A patent/JPS4844271A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU4424272A (en) | 1974-01-10 |
| DE2234881A1 (de) | 1973-04-12 |
| CS164401B1 (en) | 1975-11-07 |
| AU458692B2 (en) | 1975-03-06 |
| JPS4844271A (enrdf_load_stackoverflow) | 1973-06-26 |
| GB1378408A (en) | 1974-12-27 |
| CA952901A (en) | 1974-08-13 |
| HU165019B (enrdf_load_stackoverflow) | 1974-06-28 |
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