SU417422A1 - - Google Patents

Info

Publication number

SU417422A1

SU417422A1 SU1685996A SU1685996A SU417422A1 SU 417422 A1 SU417422 A1 SU 417422A1 SU 1685996 A SU1685996 A SU 1685996A SU 1685996 A SU1685996 A SU 1685996A SU 417422 A1 SU417422 A1 SU 417422A1

Authority

SU

USSR - Soviet Union

Prior art keywords

alkaloids

atropine sulfate

chloroform

sulfate

apoatropine

Prior art date

1971-07-23

Links

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• Global Dossier
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• WPUIZWXOSDVQJU-XYPWUTKMSA-N [(1s,5r)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylprop-2-enoate Chemical compound C([C@H]1CC[C@@H](C2)N1C)C2OC(=O)C(=C)C1=CC=CC=C1 WPUIZWXOSDVQJU-XYPWUTKMSA-N 0.000 description 12
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
• HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 description 8
• 229930013930 alkaloid Natural products 0.000 description 8
• 229960002028 atropine sulfate Drugs 0.000 description 8
• 238000000034 method Methods 0.000 description 7
• 239000007864 aqueous solution Substances 0.000 description 3
• 238000000605 extraction Methods 0.000 description 3
• 239000012535 impurity Substances 0.000 description 3
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
• 238000000746 purification Methods 0.000 description 2
• 239000000741 silica gel Substances 0.000 description 2
• 229910002027 silica gel Inorganic materials 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
• VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
• 235000011114 ammonium hydroxide Nutrition 0.000 description 1
• OSOHBQZPFDDOMK-UHFFFAOYSA-N azane;propan-2-one Chemical compound N.CC(C)=O OSOHBQZPFDDOMK-UHFFFAOYSA-N 0.000 description 1
• 239000003153 chemical reaction reagent Substances 0.000 description 1
• 239000002026 chloroform extract Substances 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Cited By (4)