SU276937A1 - - Google Patents
Info
- Publication number
- SU276937A1 SU276937A1 SU1244752A SU1244752A SU276937A1 SU 276937 A1 SU276937 A1 SU 276937A1 SU 1244752 A SU1244752 A SU 1244752A SU 1244752 A SU1244752 A SU 1244752A SU 276937 A1 SU276937 A1 SU 276937A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- adamantylamino
- glucuronic acid
- mixture
- aminoadamantane
- glucuronide
- Prior art date
Links
- 229940097043 Glucuronic Acid Drugs 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- AEMOLEFTQBMNLQ-QIUUJYRFSA-N β-D-glucuronic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-QIUUJYRFSA-N 0.000 description 3
- DKNWSYNQZKUICI-UHFFFAOYSA-N Amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000005020 pharmaceutical industry Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
Description
СПОСОБ ПОЛУЧЕНИЯ METHOD OF OBTAINING
Изобретение касаетс получени соединейий , которые могут найти широкое нрименение в фармацевтической промышленности.The invention relates to the preparation of compounds which can be widely used in the pharmaceutical industry.
Предлагаетс новый способ получени не описанных в литературе адамантиламино-Nглюкуронидов , заключающийс в том, что аминоадамантан подвергают взаимодействию с глюкуроновой кислотой в безводном органическом растворителе при кратковременном кип чении смеси эквимол рных количеств исходных компонентов с последующим выделением целевого продукта известными приемами .A new method is proposed for the preparation of adamantylamino-Nglucuronides not described in the literature, namely that aminoadamantane is reacted with glucuronic acid in an anhydrous organic solvent during a short-term boiling of a mixture of equimolar amounts of the starting components followed by isolation of the target product by known methods.
Пример. 19,4 г (0,1 моль) глюкуроновой кислоты раствор ют в кнп шем абсолютном этаноле (1000 мл) и к раствору добавл ют 15,1 г (0,1 моль) аминоадамантана в 300 мл бензола. Реакционную с.месь кип т т в течение 1 час. Выпавший осадок после охлаждени отфильтровывают, промывают на фильтре этанолом и сушат. Получают 27,8 г (85% от теоретического) белого кристаллического аналитически чистого без перекристаллизации продукта с т. нл. 181 - 182°С (с разложением ).Example. 19.4 g (0.1 mol) of glucuronic acid is dissolved in more than 100% absolute ethanol (1000 ml) and 15.1 g (0.1 mol) of aminoadamantane in 300 ml of benzene is added to the solution. The reaction mixture is boiled for 1 hour. The precipitate formed after cooling is filtered, washed on the filter with ethanol and dried. Obtain 27.8 g (85% of theoretical) of a white crystalline analytically pure product without recrystallization with t. NL. 181 - 182 ° С (with decomposition).
Найдено, %: С 58,61; И 7,78; N 4,64. CisHssOeN.Found,%: C 58.61; And 7.78; N 4.64. CisHssOeN.
Вычислено, %: С 58,75; Н 7,68; N 4,27. Calculated,%: C 58.75; H 7.68; N 4.27.
Предмет и з о б р е т е н и Subject and title
Способ получени адамантиламино-Ы-глюкуронида , отличающийс тем, что смесь эквимол рных количеств амнноадамантана н глюкуроновой кислоты кип т т в безводном органическом растворителе не более часа с последующим выделением целевого продукта известными приема.ми. АДАМАНТИЛАМИНО-Ы-ГЛЮКУРОНИДАThe method of producing adamantylamino-N-glucuronide, characterized in that a mixture of equimolar amounts of amnnoadamantane and glucuronic acid is boiled in an anhydrous organic solvent for not more than an hour, followed by isolation of the target product by known methods. Adamantylamino-y-glucuronide
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU276937A1 true SU276937A1 (en) |
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