SU261381A1 - METHOD OF OBTAINING 2,2-BIS- (ALKTIO)-PROPANOLOV-1 - Google Patents
METHOD OF OBTAINING 2,2-BIS- (ALKTIO)-PROPANOLOV-1Info
- Publication number
- SU261381A1 SU261381A1 SU1038632A SU1038632A SU261381A1 SU 261381 A1 SU261381 A1 SU 261381A1 SU 1038632 A SU1038632 A SU 1038632A SU 1038632 A SU1038632 A SU 1038632A SU 261381 A1 SU261381 A1 SU 261381A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- bis
- alktio
- obtaining
- propanolov
- propanol
- Prior art date
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- -1 isobutylthio Chemical group 0.000 description 3
- AHQLLEIQWZZXGP-UHFFFAOYSA-N (2-methyl-1,3-dioxolan-2-yl)methanol Chemical compound OCC1(C)OCCO1 AHQLLEIQWZZXGP-UHFFFAOYSA-N 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- BDFAOUQQXJIZDG-UHFFFAOYSA-N 2-methylpropane-1-thiol Chemical compound CC(C)CS BDFAOUQQXJIZDG-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L na2so4 Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propanol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing Effects 0.000 description 1
Description
ll
Предложен способ получени 2,2-би€-(алктио )-пропанолов-1, заключающийс во взаимодействии 2-метил-2-метилол-1,3-диоксолана с меркаптанами при температуре 50°С с последующей юерегонкой реакциоиной массы.A method for the preparation of 2,2-bi-1- (alktio) propanol-1 is proposed, which involves the interaction of 2-methyl-2-methylol-1,3-dioxolane with mercaptans at a temperature of 50 ° C, followed by reduction of the reaction mass.
Полученные соединени в литературе не опЕсаны и могут найти применение как «сходные вещества в синтезе лекарственных препаратов , а также в других област х народного хоз йства.The compounds obtained in the literature are not opsans and can be used as "similar substances in the synthesis of drugs, as well as in other areas of the national economy.
Пример. Смесь 11,8 г 2-метил-2-метилол1 ,3-диоксола1на и 18 г изобутилмеркаптана нагревают в колбе с обратным холодильником при температуре 50°С в течение 6 час, при этом выдел етс нерастворимый ъ целевом продукте этиленгликоль. Реакцию останавливают по прекращении увеличени сло этиленгликол . Последний от целевого продукта отдел ют на; делительной воронке, промывают эфиром, целевой П|родукт и эфирный слой объедин ют, сушат сульфатом натри , растворитель отгон ют, а остаток подвергают перегонке :В вакууме. Легколетучие вещества собирают в ловушке, охлажденной до -60°С. При этом получают 15,3 г (65%) 2,2-бис-(изобутилтио )-1Пропанола-1 с т. кип. 124-125°С (2 мм рт. ст.); п 1,5028; df 0,9849.Example. A mixture of 11.8 g of 2-methyl-2-methylol1, 3-dioxole1 and 18 g of isobutyl mercaptan is heated in a flask under reflux at 50 ° C for 6 hours, and insoluble ethylene glycol is obtained. The reaction is stopped when the increase in the ethylene glycol layer is stopped. The latter is separated from the target product by; the separatory funnel is washed with ether, the target product and the ether layer are combined, dried with sodium sulfate, the solvent is distilled off, and the residue is subjected to distillation: in vacuo. Volatile substances are collected in a trap cooled to -60 ° C. 15.3 g (65%) of 2,2-bis- (isobutylthio) -1-propanol-1 are obtained with a bale. 124-125 ° С (2 mm of mercury); p 1.5028; df 0.9849.
Вычи-слено, %: С 55,88; Н 10,24; S 27,13. MR 70,365.Calculator,%: C 55.88; H 10.24; S 27.13. MR 70,365.
Таким же о-бразом получены:The same o-braz obtained:
2,2-бис-(Бутилтио)-прот анол-1; выход 70%; т. кип. 126-128°С (при 2 мм рт. ст.}; п20 1,5058; df 0,9952.2,2-bis- (Butylthio) anol-1 prot; yield 70%; m.p. 126-128 ° C (at 2 mmHg. Art.}; R20 1.5058; df 0.9952.
Найдено, %: С 56,06, 55,84; Н 10,40, 10,45; S 26,90; 26,80. MR 70,48.Found,%: C 56.06, 55.84; H 10.40, 10.45; S 26.90; 26.80. MR 70.48.
Вычислено, %: С 55,88; Н 10,24; S 27,13. MR 70,365.Calculated,%: C 55.88; H 10.24; S 27.13. MR 70,365.
2,2-бис - (Пропилтио) - пропанол -1; выход 78%; т. КИП. 102-104°С (1,5 мм рт. ст. п20 1,5090; df 1,0085.2,2-bis - (Propylthio) - propanol -1; yield 78%; T. KIP. 102-104 ° C (1.5 mmHg. Art. P20 1.5090; df 1.0085.
Найдено, %: С 51,55; 31,82; Н 9,75; 9,91; S 30,40; 30,50. MR 61,57.Found,%: C 51.55; 31.82; H 9.75; 9.91; S 30.40; 30.50. MR 61.57.
Вычислено, %: С 51,87; Н 9,67; S 30,78. MR 61,129.Calculated,%: C, 51.87; H 9.67; S 30.78. MR 61,129.
2020
Предмет изобретени Subject invention
Способ получени 2,2-бис-(алктио)-пропанолов-1 , отличающийс тем, что 2-метил-2метилол-1 ,3-диоксолан подвергают взаимодействию с меркаптанами при температуре с последующей перегонкой реакционThe method of obtaining 2,2-bis- (alktio) -propanol-1, characterized in that 2-methyl-2methylol-1, 3-dioxolane is reacted with mercaptans at a temperature followed by distillation of the reaction
Publications (1)
Publication Number | Publication Date |
---|---|
SU261381A1 true SU261381A1 (en) |
Family
ID=
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR0149006B1 (en) | Diethers usable in the preparation of ziegler natta catalysts | |
Stevens et al. | Carbodiimides. Dehydration of ureas | |
SU261381A1 (en) | METHOD OF OBTAINING 2,2-BIS- (ALKTIO)-PROPANOLOV-1 | |
SU188963A1 (en) | METHOD OF OBTAINING 1,2,2-TRIS (ALKTIO) PROPANOLS | |
SU187791A1 (en) | METHOD OF OBTAINING o) -ISOCIANAGALKYL TRIACYLSYLANS | |
SU181089A1 (en) | ||
SU187037A1 (en) | METHOD OF OBTAINING ALKTHYOETOXYLICATED 1,3-DIOXOLANES | |
SU245776A1 (en) | METHOD FOR OBTAINING ALKILALCOXIFORMIMIDES O- | |
SU447883A1 (en) | Method of producing fluoroalkyl esters of chloropropionic acid | |
SU1735264A1 (en) | Method of vinyl enters synthesis | |
SU192814A1 (en) | METHOD FOR OBTAINING FLUORINE-CONTAINING SILICON ORGANIC MONOMERS | |
SU245097A1 (en) | METHOD OF OBTAINING 0-DIGALOIDFORMMIN 0- | |
SU186451A1 (en) | METHOD OF OBTAINING VINYLOXYLCOCOXYLKINOLS | |
SU777033A1 (en) | Method of preparing 2-(beta-chloroethyl)-1,3-dioxolane | |
SU275062A1 (en) | ||
SU502879A1 (en) | The method of obtaining - (carbethoxy) - monoalkylthioacetamide | |
SU486010A1 (en) | The method of obtaining derivatives of perfluoromethacrylic acid | |
SU771090A1 (en) | Method of preparing tertiary alkylthienine alcohols | |
SU546607A1 (en) | Method for isolating amino alcohols or their salts | |
SU197552A1 (en) | METHOD OF OBTAINING p-CHLORETOXYMETHYL ETHER R'-NONILTIOETHANOL-1 | |
SU235034A1 (en) | METHOD OF OBTAINING 1- (Pyridyl-4 ') - BENZIMIDAZOLE | |
SU198343A1 (en) | METHOD OF OBTAINING SECONDARY AROMATIC AMINES | |
SU161783A1 (en) | ||
SU166019A1 (en) | METHOD OF OBTAINING EVGENOL | |
SU825487A1 (en) | Method of producing hydroquinone monomethylether |