SU196857A1 - METHOD OF OBTAINING 2-MERCAPTOTYLZOLINE OR TETRAHYDROTIAZINE - Google Patents
METHOD OF OBTAINING 2-MERCAPTOTYLZOLINE OR TETRAHYDROTIAZINEInfo
- Publication number
- SU196857A1 SU196857A1 SU1088426A SU1088426A SU196857A1 SU 196857 A1 SU196857 A1 SU 196857A1 SU 1088426 A SU1088426 A SU 1088426A SU 1088426 A SU1088426 A SU 1088426A SU 196857 A1 SU196857 A1 SU 196857A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- tetrahydrotiazine
- mercaptotylzoline
- obtaining
- yield
- carbonic acid
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000009835 boiling Methods 0.000 description 2
- QGJOPFRUJISHPQ-UHFFFAOYSA-N carbon bisulphide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- AJZGFFKDLABHDD-UHFFFAOYSA-N thiazinane Chemical compound C1CCSNC1 AJZGFFKDLABHDD-UHFFFAOYSA-N 0.000 description 2
- WGJCBBASTRWVJL-UHFFFAOYSA-N 1,3-thiazolidine-2-thione Chemical compound SC1=NCCS1 WGJCBBASTRWVJL-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- OCVLSHAVSIYKLI-UHFFFAOYSA-O SC=1SC=C[NH+]=1 Chemical compound SC=1SC=C[NH+]=1 OCVLSHAVSIYKLI-UHFFFAOYSA-O 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
Предложен новый способ получени 2-меркаптотиазолииа или тетрагидротиазина кип чением внутренней co.iu соответственно (5- илн у-аминоалкилтритиоугольной кислоты. Полученные предлагаемым способом соединени обладают высокой степенью чистоты и не требуют дальнейшей очистки. Выход почти количественный .A new method for the preparation of 2-mercaptothiazolium or tetrahydrothiazine by boiling internal co. Iu, respectively (5-yl y-aminoalkyltriethio-carbonic acid) has been proposed. The compounds obtained by the proposed method have a high degree of purity and do not require further purification. The yield is almost quantitative.
Пример. 4,59 г (0,03 моль) внутренней соли р-аминоэтилтритиоугольной кислоты в 30 мл воды кип т т с обратным холодильником до полного растворени соли и обесцвечивани раствора. При этом наблюдаетс выделение сероводорода. По окончании нагревани бесцветный прозрачный раствор охлаждаетс . Выделившиес белые кристаллы 2-меркаптотиазолина отфильтровывают и высушивают . Выход продукта с т. пл. 107°С 3,5 г ( от теоретического).Example. 4.59 g (0.03 mol) of the internal salt of p-aminoethyltriethio-carbonic acid in 30 ml of water is refluxed until the salt completely dissolves and the solution becomes colorless. An emission of hydrogen sulphide is observed. At the end of the heating, the colorless clear solution is cooled. The isolated white crystals of 2-mercaptothiazoline are filtered off and dried. The product yield with so pl. 107 ° C 3.5 g (from theoretical).
Проба смешени с продуктом, полученным из р-бромэтиламина п сероуглерода, депрессии не дает.The sample mixed with the product obtained from p-bromo ethylamine and carbon disulfide does not give any depression.
Вычислено, о/о: S 53,77; N 11,76.Calculated, o / o: S 53.77; N 11.76.
CaHsNSa.CaHsNSa.
Найдено, «/о: S 53,54; N 11,49.Found, “/ o: S 53.54; N 11.49.
Аналогично получают (количественный выход ) 2-меркаптотетрагидротиазнп с т. пл. 133°С, исход из внутренней соли у-аминопронилтритиоугольной кислоты.Similarly, receive (quantitative yield) 2-mercaptotetrahydrothiaznp with so pl. 133 ° C, starting from the internal salt of γ-aminopronyltriothiol acid.
Вычислено, о/о: S 48,12; N 10,52.Calculated, o / o: S 48.12; N 10.52.
C l-l-NS-2.C l-l-NS-2.
Найдено, S 48,29; N 10,20.Found S 48.29; N 10.20.
Предмет изобретени Subject invention
Способ получени 2-меркаптотпазолнна или тетрагидротиазина, отличающийс тем, что с целью повышени выхода и чистоты продукта, внутреннюю соль р- или у-аминоалкилтритноугольпой кислоты подвергают кип чению.A method for the preparation of 2-mercaptoptazumn or tetrahydrothiazine, characterized in that in order to increase the yield and purity of the product, the internal salt of p- or y-aminoalkyltritic carbonic acid is boiled.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU196857A1 true SU196857A1 (en) |
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