SU1429032A1 - Method of analysing cerebral atherosclerosis - Google Patents

Abstract

The invention relates to medicine, more specifically to neuropathology, intended to diagnose cerebral-1 atherosclerosis. The purpose of the invention is to increase the accuracy of the diagnostic method in the early stages of the disease. The amount of luteinizing hormone (LH) in the patient's bloodstream is determined before and after 24 h after administration of 1.0 ml of 5% p-ra testosterone-propionate using a radioimmunoassay method. In healthy individuals, the loss of PH after administration of the drug drops by 50% or more. In patients with cerebral atherosclerosis, the concentration of LH after administration of 1.0 ml of 5% testosterone propionate decreases by an average of 20% and is less or even worse. (L

Description

The invention relates to medicine, namely to neuropathology, and can be used to diagnose cerebral atherosclerosis. , with

The purpose of the invention is to improve the accuracy of the method in the early stages of the disease.

The method is carried out in the following way. ten

In a patient on an empty stomach, blood is taken from the cubital vein into a centrifugal tag and centrifuged for 15 minutes at 3000 rpm. After blood sampling, the patient is injected intramuscularly | 5

1.0MP 5% testosterone-propio. Twenty-four hours after the injection, blood is re-taken from the ulnar vein. After centrifugation, a selection of two 20 samples from the sample (before and after the introduction of testosterone propionate) is taken and the radioim is the munological definition of luteinizing hormone (LH). Healthy

The level of LH after injection of 1.0 ml of 25 5% testosterone propionate drops by 50% or more. In patients with cerebral atherosclerosis, the concentration of LH in the blood after exercise is reduced by an average of 20% and the DL is less or less. even rises

Patient B, 60 years old, was admitted to the hospital with complaints of headaches without clear localization, aggravated by mental over-exhaustion, memory loss, anxious sleep, and occasionally unpleasant sensations in the region of the heart.

On the basis of a clinical, rheocephalographic examination, a diagnosis was made: initial atherosclerotic encephalopathy.

The LH was determined in blood during the stress test. The content of LH-dz in the blood before the introduction of 1.0 ml of 5% testosterone propionate was

1.1µg / l. After administration of the drug 1.1 µg / l, no decrease in the level

LH in the blood indicates a violation of the Research Institute of the Functional State of the Hypopharyngeal Arthritis System and confirms the presence of initial manifestations of cerebral atherosclerosis (NAE),

Example 2, Patient I, 50 years old, was admitted to the clinic for examination with complaints of dizziness, aggravated during sharp turns of the head, unstable headaches without clear localization, pain in the cervical and lumbar spine.

Based on a clinical and radiological examination, a preliminary diagnosis was made: NAE, spinal osteochondrosis.

Conducted stress test with the introduction of testosterone propionate.

The content of LH in the blood before the administration of the drug is 2.2 µg / l, after the administration of 1.0 µg / l, the drop in the level of LH under the influence of testosterone propionate is 54.5%. and establish the final diagnosis: cervical osteochondrosis with secondary vertebrobasilar insufficiency.

Example 3. Patient C, 64, was admitted to the hospital with complaints of headaches, aggravated by mental fatigue, memory loss, fatigue, irritability. He considers himself sick about 8 years.

During examination of the patient, LH was determined in the blood during a stress test with the introduction of testosterone propionate. The content of LH in the blood before the administration of the drug is 1.54 µg / l, after the administration of 1.24 14kg7l. The decrease in the content of LH in the blood relative to the initial level by 20% after the administration of testosterone pro.pionate indicates the presence of cerebral atherosclerosis in the patient,

The diagnosis was confirmed during examination of the patient by other methods: REG - increase in the vascular tone of the brain (ofS ".0.26 s, o, D 0.24 s). The fundus of the eye is retinal angiopati, the neurological status is a positive reflex of automatism, static ataxi, A / D 120/80.

The proposed method allows to diagnose the initial forms of cerebral atherosclerosis with high accuracy (up to 95%) and to assess the degree of functional impairment of the pituitary-gonadal system.

The method is effective in the early stage of the disease, when therapeutic and prophylactic measures are most effective, retain the ability to work of people at creative age, prevent the development of complications.

31429032

Claims (1)

The claims of the bloodstream determine the content luteinizing hormone before and through A method for diagnosing cerebral h after injecting 1.0 ml of 5% atherosclerosis by examining a cro-V solution of testosterone propionate and vi, differing in that, while decreasing this index, by 20%, in order to be less accurate and less than the original diagnostics in the early stages, in the case of cerebral atherosclerosis.