SU1195604A1 - Nitrile n-(2-carboxy-4-bromophenil)-alanine as starting product for producing oxime n acetyl-1,2,3,4-tetrahydro-6-bromoquinolone-4 possessing hypotension activity - Google Patents

Nitrile n-(2-carboxy-4-bromophenil)-alanine as starting product for producing oxime n acetyl-1,2,3,4-tetrahydro-6-bromoquinolone-4 possessing hypotension activity Download PDF

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SU1195604A1
SU1195604A1 SU843762471A SU3762471A SU1195604A1 SU 1195604 A1 SU1195604 A1 SU 1195604A1 SU 843762471 A SU843762471 A SU 843762471A SU 3762471 A SU3762471 A SU 3762471A SU 1195604 A1 SU1195604 A1 SU 1195604A1
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Prior art keywords
text
nitrile
alanine
bromoquinolone
tetrahydro
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SU843762471A
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Russian (ru)
Inventor
Ф.С. Михайлицын
Н.П. Козырева
В.И. Шведова
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Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского
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Priority to SU843762471A priority Critical patent/SU1195604A1/en
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Нит1)ил К-Nit1) silt K-

Description

Изобретение относитс  к новому химическому соединению - нитрилу N-(2-карбокси-4-бромфенш1)-й-аланина и имеет структурную формулу (I) This invention relates to a novel chemical compound, N- (2-carboxy-4-bromofensh1) -alanine nitrile, and has the structural formula (I)

CH,CHnCNCH, CHnCN

2 42 4

Описываемое соединение используют как исходный продукт, в синтезе лекарственного препарата Оксамола (оксима Ы-ацетил-1,2,3,4-тетрагидро-6-бромхинолона-4 , обладающего диуретической и гипотензивной активностью.The described compound is used as a starting product in the synthesis of the drug Oksamol (oxime L-acetyl-1,2,3,4-tetrahydro-6-bromoquinolone-4, which has diuretic and hypotensive activity.

Целью изобретени  - изыскание нового ,л более дешевого исходного продукта дл  получени  лекарственного препарата оксамола с большим выходом .The aim of the invention is to find a new, l cheaper starting product for obtaining the drug oxamol with a high yield.

П р и м ер 1. Получение нитрила N-(2-карб6кси-4-бромфенил)-А-аланина .Example 1: Preparation of N- (2-carb6-xi-4-bromophenyl) -A-alanine nitrile.

К 9,5 г (0,05м) нитрила Н-(2-кар;D ел боксифен1ш)-А-алаш на в 50 мл лед ной уксусной кислоты прикапывают при пеOt ) мешивании температур 3 мл брома в 10 МП лед ной уксусной кислоты в течение 10 мин по окончании прибавлени  реакционную массу продолжают перемешивать еще 10 мин, а затем выпивают в 200 мл воды. Выделившийс  осадок фильтруют, промывают водой выход 12,8 г (95%), т.пл.182-184 (из дихлорэтана), блест щие бесцветные кристаллы с сероватым оттенком.To 9.5 g (0.05 m) of nitrile H- (2-carate; D ale boxifen1x) -Al-alash in 50 ml of glacial acetic acid is added dropwise at neOt) by stirring temperatures of 3 ml of bromine in 10 MP of glacial acetic acid for 10 minutes after the end of the addition, the reaction mass is continued to be stirred for another 10 minutes, and then it is drunk in 200 ml of water. The precipitate formed is filtered, washed with water, yield 12.8 g (95%), mp 198-284 (from dichloroethane), brilliant colorless crystals with a grayish tint.

Найдено,%: С 44,7; Н 3,2; N 10,5.Found,%: C 44.7; H 3.2; N 10.5.

,.,

Claims (1)

<claim-text> <claim-text>сосн,</claim-text> <claim-text>сосн.</claim-text> <claim-text>1 ской промышленностью в крупном масштабе·,’</claim-text> <claim-text>возможность синтеза описываемого в заявке исходного вещества с использованием процесса, не требующих специального оборудования и реактивов;</claim-text> <claim-text>, высокие выходы промежуточных про-, дуктов на всех стадиях при синтезе препарата оксамола.</claim-text><claim-text> <claim-text> pine, </ claim-text> <claim-text> pine. </ claim-text> <claim-text> 1 industry on a large scale ·, ’</ claim-text> <claim-text> the ability to synthesize the original substance described in the application using a process that does not require special equipment and reagents; </ claim-text> <claim-text>, high yields of intermediate pro-products at all stages in the synthesis of the drug oxamol. </ claim-text>
SU843762471A 1984-06-29 1984-06-29 Nitrile n-(2-carboxy-4-bromophenil)-alanine as starting product for producing oxime n acetyl-1,2,3,4-tetrahydro-6-bromoquinolone-4 possessing hypotension activity SU1195604A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU843762471A SU1195604A1 (en) 1984-06-29 1984-06-29 Nitrile n-(2-carboxy-4-bromophenil)-alanine as starting product for producing oxime n acetyl-1,2,3,4-tetrahydro-6-bromoquinolone-4 possessing hypotension activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU843762471A SU1195604A1 (en) 1984-06-29 1984-06-29 Nitrile n-(2-carboxy-4-bromophenil)-alanine as starting product for producing oxime n acetyl-1,2,3,4-tetrahydro-6-bromoquinolone-4 possessing hypotension activity

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SU1195604A1 true SU1195604A1 (en) 1991-05-07

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SU843762471A SU1195604A1 (en) 1984-06-29 1984-06-29 Nitrile n-(2-carboxy-4-bromophenil)-alanine as starting product for producing oxime n acetyl-1,2,3,4-tetrahydro-6-bromoquinolone-4 possessing hypotension activity

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент FR Э 2487196, кл. А 61 К 31/435, опублик.1982. *

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