USRE29468E - Process for making a C1 -C7 aliphatic hydrocarbyl ester of an N-[2,6-di(C1 -C7 alkyl)phenyl] α-aminocarboxylic acid - Google Patents

Process for making a C1 -C7 aliphatic hydrocarbyl ester of an N-[2,6-di(C1 -C7 alkyl)phenyl] α-aminocarboxylic acid Download PDF

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USRE29468E
USRE29468E US05/701,723 US70172376A USRE29468E US RE29468 E USRE29468 E US RE29468E US 70172376 A US70172376 A US 70172376A US RE29468 E USRE29468 E US RE29468E
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alkyl
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ester
aniline
hydrochloride
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Anthony B. Clayton
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BOOTS HERCULES AGROCHEMICALS Co A PARTNERSHIP OF
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Definitions

  • This invention is in the chemical arts. In particular it resides in that part of organic chemistry having to do with aromatic aminocarboxylic esters.
  • hydrocarbyl as used in this specification means a hydrocarbon radical. Accordingly, C 1 -C 7 aliphatic hydrocarbyl encompasses C 1 -C 7 alkyl, C 2 -C 7 alkenyl and C 2 -C 7 alkynyl. These radicals can be straight or branched R' and R" can be the same or different. Examples of C 1 -C 7 alkyl include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, and the like.
  • Examples of C 2 -C 7 alkenyl include vinyl(ethenyl), allyl, propenyl, isopropenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-methylpropenyl, and the like.
  • Examples of C 2 -C 7 alkynyl include acetenyl (ethynyl), 1-propynyl, 2-propynyl and the like.
  • the process of this invention comprises effecting reaction of the corresponding phenylamine and the .[.haloalkanoic.]. .Iadd.chloroalkanoic .Iaddend.acid ester with a catalytic quantity of 2,6-di(C 1 -C 7 alkyl)aniline hydrochloride.
  • the 2,6-di(C 1 -C 7 alkyl)aniline hydrochloride is the hydrochloride of the phenylamine reactant.
  • the phenylamine reactant and the aniline hydrochloride are admixed and the .[.haloalkanoic.]. .Iadd.chloroalkanoic .Iaddend.acid ester is slowly admixed with the resulting mixture.
  • the quantity of 2,6-di(C 1 -C 7 alkyl)aniline hydrochloride employed as catalyst is a catalytic quantity.
  • concentration of the hydrochloride is about 0.5-5% by weight of the phenylamine reactant.
  • the catalyst can be added as such to the phenylamine reactant or, particularly in the embodiment in which the 2,6-di(C 1 -C 7 alkyl)aniline hydrochloride is the hydrochloride of the phenylamine reactant, it can be formed in situ in the phenylamine reactant by admixing with the reactant a quantity of hydrochloric acid equivalent to the desired catalyst concentration.
  • the reaction can be carried out neat or in the presence of an inert liquid reaction medium for better control of the reaction temperature.
  • a liquid reaction medium include benzene, toluene, xylene, and the like.
  • the preferred reaction temperature range is 100°-250° C. However, higher and lower temperatures are within the broader concepts of this invention. On the other hand, the higher the reaction temperature, the higher is the concentration of impurities such as the dicarboxylic acid ester.
  • reaction time is generally in the range from about 15 minutes to about 10 hours. Lesser and greater reaction times, however, are within the broader concepts of this invention. On the other hand, in general a reaction time of less than about 15 minutes can result in less than a practical conversion of the phenylamine and the haloalkanoic acid ester to the desired product, while in general a reaction time greater than about 7 hours can result in substantial concentrations of impurities.
  • the reaction mixture can be used as in the reaction of the intermediate compound to form the desired end use compound such as one of those disclosed in the cited published patent application, or the reaction mixture can be treated to isolate the intermediate compound with the desired degree of purity.
  • a treatment in one embodiment of the invention comprises admixing the reaction mixture with an inert nonpolar solvent (for example, benzene, toluene, xylene, and the like) for the intermediate compound in quantity preferably sufficient to dissolve substantially all the intermediate compound, if such is not already present, separating solid aniline hydrochloride, if any, from the resulting solution, washing the solution with a weak aqueous solution of an inorganic acid to remove unreacted amine, and removing the solvent by distillation or evaporation.
  • an inert nonpolar solvent for example, benzene, toluene, xylene, and the like
  • This example illustrates the synthesis of N-(2,6-diethylphenyl)glycine ethyl ester by a specific embodiment of the inventive process in which the reaction is carried out neat or without an inert liquid reaction medium.
  • This example illustrates the preparation of N-(2,6-diethylphenyl)glycine ethyl ester by another specific embodiment of the inventive process in which the reaction is carried out in an inert liquid reaction medium.
  • the reaction mixture is then cooled to room temperature (20°-25° C.), toluene (165 w) is added, and the resulting diluted mixture filtered to remove solid 2,6-diethylaniline hydrochloride.
  • the resulting filtrate is washed at 80° C. twice with water (400 v each time) at at room temperature (20°-25° C.) 7 times with a 10% aqueous solution (120 v each time) of H 2 SO 4 , and once with water (200 v).
  • the washed solution is dried over magnesium sulfate, and the toluene removed by evaporation to dryness under reduced pressure.
  • the residue (135.8 w) consists essentially of N-(2,6-diethylphenyl)glycine ethyl ester.
  • a typical analysis of the residue by liquid chromotography is 92% N-(2,6-diethylphenyl)glycine ethyl ester and 2.9% N-bis(carbethoxymethyl)-2,6-diethylaniline with impurities at a minimum.
  • This example illustrates the preparation of N-(2,6-diethylphenyl)glycine allyl ester by a specific embodiment of the process of this invention.
  • the wash liquid is mixed with the filtrate and the solution is washed once with water (40 v), once with a 10% aqueous solution (40 v) of H 2 SO 4 , and 3 times with water (40 v each time).
  • the washed solution is dried over MgSO 4 , overnight, the MgSO 4 is removed by filtration, and the solvent is removed from the filtrate by distillation.
  • the residue (7.0 w) is typically a dark brown resin which consists essentially of N-(2,6-diethylphenyl)glycine allyl ester with impurities at a minimum.
  • This example illustrates the preparation of N-(2-ethyl-6-methylphenyl)glycine allyl ester by a specific embodiment of the process of this invention.
  • 2-Methyl-6-ethylaniline (10.5 w), 2,6-diethylaniline hydrochloride (0.4 w) and dry toluene (3.1 w) are stirred together. While the resulting mixture is refluxed at 160° C., allyl chloroacetate (10.5 w) is added slowly. After addition of the allyl chloroacetate has been completed, the resulting reaction mixture is refluxed at 155°-162° C. for 5 hours.
  • This example illustrates the preparation of N-(2,6-diethylphenyl)glycine 1-butyn-3-yl ester by a specific embodiment of the process of this invention.
  • the diluted mixture is filtered to remove solids and the filtrate is washed once with water (100 v), once with a 10% aqueous solution (100 v) of H 2 SO 4 , and three times with water (100 v each time).
  • the washed solution is dried over MgSO 4 and, after removal of the MgSO 4 by filtration, the toluene is removed by distillation.
  • the residue (22.3 w) is typically an amber liquid. It consists essentially of N-(2,6-diethylphenyl)glycine 1butyn-3-yl ester with a minimum of impurities.
  • the residue (10.0 w) is typically an amber liquid. It consists essentially of N-(2-ethyl-6-methylphenyl)glycine 1-butyn-3-yl ester with a minimum of impurities.
  • this invention provides a process for reacting the phenylamine and .[.haloalkanoic.]. .Iadd.chloroalkanoic .Iaddend.acid ester corresponding to an intermediate compound of the above formula I to obtain said intermediate compound with a minimum of impurities.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract

Disclosed is a process for making a C1 -C7 aliphatic hydrocarbyl ester of an N-[2,6-(C1 -C7 alkyl)phenyl] α-amino-carboxylic acid from the corresponding 2,6-di(C1 -C7 alkyl)aniline and the corresponding chlorocarboxylic acid ester, which comprises effecting with a catalytic quantity of di(C1 -C7 alkyl)aniline hydrochloride the reaction of said aniline and said ester.

Description

This invention is in the chemical arts. In particular it resides in that part of organic chemistry having to do with aromatic aminocarboxylic esters.
C1 -C7 Aliphatic hydrocarbyl esters of N-[2,6-di(C1 -C7 alkyl)phenyl] α-aminocarboxylic acids have utility as intermediate compounds in the preparation of certain herbicidal esters such as those disclosed in The Netherlands published pat. application No. 73.03363, open to public inspection on Sept. 12, 1973.
These intermediate compounds are represented by the structural formula I: ##STR1## in which R is C1 -C7 aliphatic hydrocarbyl, and R' and R" are C1 -C7 alkyl.
The term "hydrocarbyl" as used in this specification means a hydrocarbon radical. Accordingly, C1 -C7 aliphatic hydrocarbyl encompasses C1 -C7 alkyl, C2 -C7 alkenyl and C2 -C7 alkynyl. These radicals can be straight or branched R' and R" can be the same or different. Examples of C1 -C7 alkyl include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, and the like. Examples of C2 -C7 alkenyl include vinyl(ethenyl), allyl, propenyl, isopropenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-methylpropenyl, and the like. Examples of C2 -C7 alkynyl include acetenyl (ethynyl), 1-propynyl, 2-propynyl and the like.
These intermediate compounds in general can be made by a process in which the phenylamines and .[.haloalkanoic.]. .Iadd.bromoalkanoic .Iaddend.acid esters corresponding to them are reacted in an inert liquid medium containing a base such as potassium hydroxide or the like. The desired reaction is depicted by the equation: ##STR2## X in the above formulas is .[.halo. However, the resulting reaction mixture has a number of impurities such as, for example, the dicarboxylic acid ester of the formula II: ##STR3## and products resulting from saponification of the ester moiety. Consequently, isolation of the desired compound in the desired degree of purity if difficult to obtain, and the yield of the desired compound is lower than desired..]. .Iadd.bromo. When the ester reactant is a chloroalkanoic acid ester, the reaction depicted by the equation does not go. .Iaddend.
.[.This invention minimizes these disadvantages of the foregoing process..].
.Iadd.This invention provides a process in which the phenylamine and the chloroalkanoic acid ester react. .Iaddend.
In brief, the process of this invention comprises effecting reaction of the corresponding phenylamine and the .[.haloalkanoic.]. .Iadd.chloroalkanoic .Iaddend.acid ester with a catalytic quantity of 2,6-di(C1 -C7 alkyl)aniline hydrochloride. In the preferred embodiment of this invention the 2,6-di(C1 -C7 alkyl)aniline hydrochloride is the hydrochloride of the phenylamine reactant.
In the preferred practice of the process of this invention the phenylamine reactant and the aniline hydrochloride are admixed and the .[.haloalkanoic.]. .Iadd.chloroalkanoic .Iaddend.acid ester is slowly admixed with the resulting mixture.
As above stated, the quantity of 2,6-di(C1 -C7 alkyl)aniline hydrochloride employed as catalyst is a catalytic quantity. In general satisfactory results are obtained when the concentration of the hydrochloride is about 0.5-5% by weight of the phenylamine reactant.
In the preferred practice of the process the catalyst can be added as such to the phenylamine reactant or, particularly in the embodiment in which the 2,6-di(C1 -C7 alkyl)aniline hydrochloride is the hydrochloride of the phenylamine reactant, it can be formed in situ in the phenylamine reactant by admixing with the reactant a quantity of hydrochloric acid equivalent to the desired catalyst concentration.
The reaction can be carried out neat or in the presence of an inert liquid reaction medium for better control of the reaction temperature. Examples of such a liquid reaction medium include benzene, toluene, xylene, and the like.
The preferred reaction temperature range is 100°-250° C. However, higher and lower temperatures are within the broader concepts of this invention. On the other hand, the higher the reaction temperature, the higher is the concentration of impurities such as the dicarboxylic acid ester.
Although in the usual practice of the process of this invention the reaction is carried out at atmospheric pressure, under the broader concepts of this invention higher and lower pressures can be employed.
The reaction time is generally in the range from about 15 minutes to about 10 hours. Lesser and greater reaction times, however, are within the broader concepts of this invention. On the other hand, in general a reaction time of less than about 15 minutes can result in less than a practical conversion of the phenylamine and the haloalkanoic acid ester to the desired product, while in general a reaction time greater than about 7 hours can result in substantial concentrations of impurities.
After completion of the reaction the reaction mixture can be used as in the reaction of the intermediate compound to form the desired end use compound such as one of those disclosed in the cited published patent application, or the reaction mixture can be treated to isolate the intermediate compound with the desired degree of purity. Such a treatment in one embodiment of the invention comprises admixing the reaction mixture with an inert nonpolar solvent (for example, benzene, toluene, xylene, and the like) for the intermediate compound in quantity preferably sufficient to dissolve substantially all the intermediate compound, if such is not already present, separating solid aniline hydrochloride, if any, from the resulting solution, washing the solution with a weak aqueous solution of an inorganic acid to remove unreacted amine, and removing the solvent by distillation or evaporation.
The best mode now contemplated for carrying out the process of this invention is illustrated by the following examples of specific embodiments thereof. This invention is not limited to these embodiments. In these examples all percentages are by weight unless otherwise indicated, all parts by weight are indicated by w, all parts by volume are indicated by v, and each part by weight w bears the same relationship to each part by volume v as the kilogram does to the liter.
EXAMPLE 1
This example illustrates the synthesis of N-(2,6-diethylphenyl)glycine ethyl ester by a specific embodiment of the inventive process in which the reaction is carried out neat or without an inert liquid reaction medium.
A mixture of 2,6-diethylaniline (30 w) and 2,6-diethylaniline hydrochloride (1 w) is stirred and heated to 180° C. Ethyl chloroacetate (12.2 w) is added dropwise over 15 minutes to the mixture and the temperature of the reaction mixture is maintained at 180° C. for 15 minutes after completion of the addition of the ethyl chloroacetate.
After cooling the reaction mixture to room temperature (20°-25° C.) benzene (100 v) is admixed with the reaction mixture, and the resulting mixture is filtered. The filtrate is washed twice with water (35 v each time), 4 times with a 10% aqueous solution (35 v each time) of H2 SO4, and once with water (35 v). The washed solution is dried over sodium sulfate and the solvent removed therefrom by evaporating to dryness under reduced pressure. The residue (18.9 w) consists essentially of N-(2,6-diethylphenyl)glycine ethyl ester. A typical concentration of the ester in the residue as determined by liquid chromotography is 80%.
EXAMPLE 2
This example illustrates the preparation of N-(2,6-diethylphenyl)glycine ethyl ester by another specific embodiment of the inventive process in which the reaction is carried out in an inert liquid reaction medium.
A mixture of 2,6-diethylaniline (268 w), 2,6-diethylaniline hydrochloride (5 w) and toluene (72 w) is heated to 158° C. Ethyl chloroacetate (98 w) is added all at once and the resulting reaction mixture established and maintained with stirring at 148°-150° C. for 6.5 hours.
The reaction mixture is then cooled to room temperature (20°-25° C.), toluene (165 w) is added, and the resulting diluted mixture filtered to remove solid 2,6-diethylaniline hydrochloride. The resulting filtrate is washed at 80° C. twice with water (400 v each time) at at room temperature (20°-25° C.) 7 times with a 10% aqueous solution (120 v each time) of H2 SO4, and once with water (200 v). The washed solution is dried over magnesium sulfate, and the toluene removed by evaporation to dryness under reduced pressure. The residue (135.8 w) consists essentially of N-(2,6-diethylphenyl)glycine ethyl ester.
A typical analysis of the residue by liquid chromotography is 92% N-(2,6-diethylphenyl)glycine ethyl ester and 2.9% N-bis(carbethoxymethyl)-2,6-diethylaniline with impurities at a minimum.
EXAMPLE 3
This example illustrates the preparation of N-(2,6-diethylphenyl)glycine allyl ester by a specific embodiment of the process of this invention.
2,6-Diethylaniline (11.6 w), 2,6-diethylaniline hydrochloride (0.4 w) and dry toluene (3.1 w) are stirred together. While the resulting mixture is reflexed at 160° C. allyl chloroacetate (10.5 w) is added slowly thereto. The resulting reaction mixture is refluxed at 145° C. for 2 hours and then cooled to 20°-25° C. Toluene (75 v) is admixed with it. Solids in the diluted reaction mixture are separated by filtration and washed with toluene. The wash liquid is mixed with the filtrate and the solution is washed once with water (40 v), once with a 10% aqueous solution (40 v) of H2 SO4, and 3 times with water (40 v each time). The washed solution is dried over MgSO4, overnight, the MgSO4 is removed by filtration, and the solvent is removed from the filtrate by distillation. The residue (7.0 w) is typically a dark brown resin which consists essentially of N-(2,6-diethylphenyl)glycine allyl ester with impurities at a minimum.
EXAMPLE 4
This example illustrates the preparation of N-(2-ethyl-6-methylphenyl)glycine allyl ester by a specific embodiment of the process of this invention. 2-Methyl-6-ethylaniline (10.5 w), 2,6-diethylaniline hydrochloride (0.4 w) and dry toluene (3.1 w) are stirred together. While the resulting mixture is refluxed at 160° C., allyl chloroacetate (10.5 w) is added slowly. After addition of the allyl chloroacetate has been completed, the resulting reaction mixture is refluxed at 155°-162° C. for 5 hours. Typically a few solids may appear about 1 hour after completion of the addition of the chloroacetate, but they tend to disappear by the end of the 5 hour reflux period. The reaction mixture is cooled to 20°-25° C. and allowed to sit overnight. Toluene (75 v) is added to the reaction mixture. The resulting solution is washed once with water (50 v), twice with a 10% aqueous solution (50 v each time) of H2 SO4, and three times with water (50 v each time). The washed solution is dried over MgSO4, the MgSO4 is removed by filtration, and the solvent is removed by distillation. The residue (4.7 w) is typically a dark brown liquid. It consists essentially of N-(2-ethyl-6-methylphenyl)glycine allyl ester with a minimum of impurities.
EXAMPLE 5
This example illustrates the preparation of N-(2,6-diethylphenyl)glycine 1-butyn-3-yl ester by a specific embodiment of the process of this invention.
Stirred together at reflux (140° C.) are 2,6-diethylaniline (25.3 w), 2,6-diethylaniline hydrochloride (1.0 w), and dry toluene (8 w) to form a mixture. 1-Butyn-3-yl chloroacetate (25.0 w) is admixed slowly with the mixture, and the resulting reaction mixture is refluxed 2 hours at 155° C. The reaction mixture is cooled to 20°-25° C. and toluene (150 v) is added. The diluted mixture is filtered to remove solids and the filtrate is washed once with water (100 v), once with a 10% aqueous solution (100 v) of H2 SO4, and three times with water (100 v each time). The washed solution is dried over MgSO4 and, after removal of the MgSO4 by filtration, the toluene is removed by distillation. The residue (22.3 w) is typically an amber liquid. It consists essentially of N-(2,6-diethylphenyl)glycine 1butyn-3-yl ester with a minimum of impurities.
EXAMPLE 6
This example illustrates the synthesis of N-(2-ethyl-6-methylphenyl)glycine 1-butyn-3-yl ester by a specific embodiment of the invention process.
Stirred together at reflux (140° C.) are 2-ethyl-6-methylaniline (22.95 w), 2,6-diethylaniline hydrochloride (1.0 w), and dry toluene (8 w). To this mixture is slowly added 1-butyn-3-yl chloroacetate (25.0 w). The resulting reaction mixture is refluxed 2 hours, and then cooled to 20°-25° C. After addition of toluene (150 v) to the reaction mixture, the diluted reaction mixture is filtered to remove solids, and the filtrate is washed with water (100 v), a 10% aqueous solution (100 v) of H2 SO4, and 3 times with water (100 v). After drying the washed solution over MgSO4, and filtering to remove the MgSO4, the toluene is removed by distillation. The residue (10.0 w) is typically an amber liquid. It consists essentially of N-(2-ethyl-6-methylphenyl)glycine 1-butyn-3-yl ester with a minimum of impurities.
Thus, this invention provides a process for reacting the phenylamine and .[.haloalkanoic.]. .Iadd.chloroalkanoic .Iaddend.acid ester corresponding to an intermediate compound of the above formula I to obtain said intermediate compound with a minimum of impurities.
Other features, advantages and specific embodiments of this invention will become readily apparent to those exercising ordinary skill in the art after reading the foregoing disclosures. In this connection, while specific embodiments of this invention have been described in considerable detail, variations and modifications of these embodiments can be effected without departing from the spirit and scope of the invention as disclosed and claimed.
The expression "consisting essentially of" as used in this specification excludes any unrecited substance at a concentration sufficient to substantially adversely affect the essential properties and characteristics of the composition being defined, while permitting the presence of one or more unrecited substances at concentrations insufficient to substantially adversely affect said essential properties and characteristics.

Claims (7)

I claim:
1. A process for synthesizing a C1 -C7 aliphatic hydrocarbyl ester of an N-[2,6-di(C1 -C7 alkyl)phenyl] α-aminocarboxylic acid from the corresponding 2,6-di(C1 -C7 alkyl)aniline and the corresponding .[.chlorocarboxylic.]. .Iadd.chloroacetic .Iaddend.acid ester, which comprises effecting with a catalytic quantity of 2,6-.Iadd.di.Iaddend.(C1 -C7 alkyl)aniline hydrochloride reaction of said aniline and said ester.
2. A process according to claim 1 in which said reaction is carried out at 100°-250° C. for a period of time from about 15 minutes to about 5 hours, and said catalytic quantity is about 0.5-5% by weight of said aniline.
3. A process according to claim 2 in which the reaction is carried out neat.
4. A process according to claim 2 in which the reaction is carried out in an inert liquid reaction medium.
5. A process according to claim 4 in which said hydrochloride is the hydrochloride salt of said aniline reactant.
6. A process according to claim 5 in which said aniline is 2,6-diethylaniline.
7. A process according to claim 6 in which said chlorocarboxylic acid ester is ethyl chloroacetate.
US05/701,723 1973-10-11 1976-07-01 Process for making a C1 -C7 aliphatic hydrocarbyl ester of an N-[2,6-di(C1 -C7 alkyl)phenyl] α-aminocarboxylic acid Expired - Lifetime USRE29468E (en)

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EP0041923A1 (en) * 1980-06-09 1981-12-16 Ciba-Geigy Ag Process for the preparation of N-(1'-alkoxycarbonylethyl)-2,6-dialkyl anilines
US4389531A (en) 1980-06-12 1983-06-21 Eastman Kodak Company Preparation of N-substituted anilines

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US3936492A (en) * 1969-10-20 1976-02-03 The Kendall Company Monomeric emulsion stabilizers
DE2802211A1 (en) * 1978-01-19 1979-07-26 Basf Ag N-SUBSTITUTED 2,6-DIALKYLANILINES AND METHOD FOR PREPARING N-SUBSTITUTED 2,6-DIALKYLANILINES
US4266071A (en) * 1980-06-09 1981-05-05 Ciba-Geigy Corporation Process for the preparation of N-(1-alkoxycarbonylethyl)-2,6-dialkylanilines
US4260782A (en) * 1980-06-09 1981-04-07 Ciba-Geigy Corporation Process for the preparation of N-(1'-alkoxycarbonylethyl)-2,6-dialkylanilines
DE3037160C2 (en) * 1980-10-01 1982-09-23 Hoechst Ag, 6000 Frankfurt Process for the preparation of optically active 2-anilinopropionic acid esters
US5324747A (en) * 1992-07-15 1994-06-28 Hoffmann-La Roche Inc. N-substituted anilines, inhibitors of phospholipases A2
US5965614A (en) * 1996-11-22 1999-10-12 Athena Neurosciences, Inc. N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

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US3402198A (en) * 1965-10-20 1968-09-17 William A. Bolhofer 2-(phenoxy), 2-(phenylthio) and 2-(anilino) substituted 2-alkylideneacetic acid derivatives

Patent Citations (1)

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US3402198A (en) * 1965-10-20 1968-09-17 William A. Bolhofer 2-(phenoxy), 2-(phenylthio) and 2-(anilino) substituted 2-alkylideneacetic acid derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041923A1 (en) * 1980-06-09 1981-12-16 Ciba-Geigy Ag Process for the preparation of N-(1'-alkoxycarbonylethyl)-2,6-dialkyl anilines
US4389531A (en) 1980-06-12 1983-06-21 Eastman Kodak Company Preparation of N-substituted anilines

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FR2247450A1 (en) 1975-05-09
AT339288B (en) 1977-10-10
GB1417837A (en) 1975-12-17
NL7413419A (en) 1975-04-15
ATA817074A (en) 1977-02-15
AR217391A1 (en) 1980-03-31
ES430867A1 (en) 1976-10-01
BR7408315D0 (en) 1975-07-29
CA1038879A (en) 1978-09-19
BE820064A (en) 1975-01-16
JPS5064232A (en) 1975-05-31
AU7421874A (en) 1976-04-15
IL45467A (en) 1978-04-30
CH587797A5 (en) 1977-05-13
ZA746497B (en) 1975-11-26
DE2447824A1 (en) 1975-04-17
JPS5540575B2 (en) 1980-10-18
IT1022762B (en) 1978-04-20
IL45467A0 (en) 1974-11-29
US3882162A (en) 1975-05-06
FR2247450B1 (en) 1979-02-16

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