SU1183074A1 - Method of differential diagnosis of tuberculosis and sarcoidosis - Google Patents

Abstract

METHOD FOR DIFFERENTIAL DIAGNOSIS OF TUBERCULOSIS AND sarcoidosis by determining the level of acidic fosfataay activity of blood leukocytes cytochemical method on tlichayuschiys in that in order to accelerate and povppeni accuracy of the method, the level of acid phosphatase activity further determined after incubation with tuberculin PPD taken along at a concentration of 15 -20 µg / ml, and at an activity level of 0.14 or less, sarcoidosis is diagnosed, and at an O level of 15 or more, tuberculosis is diagnosed. (L

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42 The invention relates to medicine and can be used in phthisiology, in particular for the differential diagnosis of tuberculosis and sarcoidosis, for example, of the lungs. The purpose of the invention is to accelerate and improve the accuracy of the method. Example 1. Patient K., 44 years old, was admitted to the clinic of chronic forms of pulmonary tuberculosis of the institute with suspected pulmonary tuberculosis, VC (-). Examination data at admission: complete blood count (leukocytes): 4,100-10 l, e-1; n-1, s-52; l-37, m-12; ESR-9 mm / h. General urine analysis without pathology. The phlegm of VK (-) .. Mantoux - ZU mm. Radiographs on both tops of the lungs are polymorphic foci with irregular contours and infiltration. The activity of acid phosphatase in the patient's blood prior to interaction with tuberculin was 1.20 SGC, and after two hours of incubation with tuberculin - 4.00 SGC. The difference of the results 4.00-1.20 2.80 SGK. The response of a patient's sensitized peripheral blood leukocytes to tuberculin in determining the activity of CF allows to diagnose tuberculosis, Example 2. Patient N. Sheiko G., 26 years old, was admitted to the clinic on March 25, 1980 with a diagnosis of infiltrative tuberculosis of the upper lobe of the right lung with disintegration. Complete blood count: leukocytes 9, 510 / L, e-1, p-2; 0-55; l-37} m-5; ESR - 50. Urinalysis - no pathology. Phlegm - BC (-} Mantoux reaction 1–1 mm. Radiography: on the left, the background of the lung fields is transparent. The root is dense. In the posterior and partially in the upper segment of the upper lobe of the lungs darkening is infiltrative-pneumonic in nature. The darkening merges with the dilated lung root. Medium and Baeal the lung sections are heavy. The diaphragm is mobile. The heart is normal. Acidic phosphatase activity in the patient's blood was 2.00 SGC before interaction with tuberculin, and after two hours of incubation with tuberculin 2.08-2, the difference of the data obtained was 2.08-2, , 08 SGK. Negative Tel'nykh KF reaction to tuberculin avoids the presence of tuberculosis process of the patient and diagnose sarcoidosis.

Claims (1)

METHOD FOR DIFFERENTIAL DIAGNOSTICS OF TUBERCULOSIS AND SARCOIDOSIS by determining the level of acid phosphatase activity in blood leukocytes by the cytochemical method, characterized in that, in order to accelerate and improve the accuracy of the method, the level of acid phosphatase activity is additionally determined after incubation with concentration 15 of tuberculin RRD taken in 15 mcg / ml, and at an activity level of 0.14 or less, sarcoidosis is diagnosed, and at a level of 0.15 or more - tuberculosis. ί · ns: