SU1163862A1 - Method of testing thyrotoxicosis cases - Google Patents

Method of testing thyrotoxicosis cases Download PDF

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Publication number
SU1163862A1
SU1163862A1 SU813282263A SU3282263A SU1163862A1 SU 1163862 A1 SU1163862 A1 SU 1163862A1 SU 813282263 A SU813282263 A SU 813282263A SU 3282263 A SU3282263 A SU 3282263A SU 1163862 A1 SU1163862 A1 SU 1163862A1
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USSR - Soviet Union
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thyrotoxicosis
content
increase
treatment
testing
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SU813282263A
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Russian (ru)
Inventor
Валерий Владимирович Натаров
Тамара Степановна Гринченко
Диана Алексеевна Дехтярь
Полина Матвеевна Песоцкая
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Харьковский научно-исследовательский институт эндокринологии и химии гормонов
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Abstract

СПОСОБ :ЛЕЧЕНИЯ БОЛЬНЫХ ТИРЕОТОКСИКОЗОМ путем медикаментозного лечени  антитиреоиднь1ми средствами, о тличающийс  тем, что, с целью снижени  осложнений, в крови определ ют содержание кортизола до и после введени  АКТГ и при увеличении его содержани  в 2,0-4,25 раэа в сравнений с исходным уровнем провод т медикаментозное лечение, а при отсутствии увеличени  провод т хирургическое лечение ..METHOD: TREATMENT OF TYREOTHOXICOSIS PATIENTS by drug treatment with anti-thyroid agents, characterized in that, in order to reduce complications, cortisol content in the blood is determined before and after the administration of ACTH and with an increase in its content of 2.0-4.25% in comparison with drug treatment is performed at baseline, and if there is no increase, surgical treatment is performed ..

Description

медицины, в частности к эндокринологии , и может быть использовано дл  вы влени  показаний к консервативному или оперативному лечению больных тиреотоксикозом.medicine, in particular to endocrinology, and can be used to identify indications for conservative or surgical treatment of patients with thyrotoxicosis.

Целью изобретени   вл етс  - снижение осложнений.The aim of the invention is to reduce the complications.

Способ осуществл етс  следующим образом.The method is carried out as follows.

У больных тиреотоксикозом в крови определ ют содержание кортизола до и после введени  АКТГ, и при увеличении его содержани  в 2,0-4,25 раза в сравнении с исходным уровнем провод т медикаментозное лечение, а при отсутствии увеличени  - хирургическое лечение.In patients with thyrotoxicosis, the content of cortisol in the blood is determined before and after administration of ACTH, and with an increase in its content of 2.0-4.25 times compared with the initial level, medical treatment is carried out, and in the absence of an increase, surgical treatment.

П р и м е р 1. Больна  Л., 19 лет, диагноз: диффузньй токсический зоб lll-IV ст., средней т жести. Болеет около 3 мес. Получала регул рно тиреостатические препараты. Однако проводима  Терапи  бьша малоэффективной.PRI me R 1. Sick L., 19 years old, diagnosis: diffuse toxic goiter, lll-IV degree, moderate. Sick about 3 months. Received regularly thyreostatic drugs. However, the therapy has been ineffective.

ки тиреотоксикоза были отчетливо выражены . Содержание кортизола в плазме крови 96 нг/мл. Через 60 мин, после внутримышечного введени  0,25 мг АКТЕ уровень кортизола составил 122 нг/мл (т.е. увеличение менее чем в 2 раза). Больна  была подвергнута оперативному лечению.Thyrotoxicosis was clearly expressed. The plasma cortisol content is 96 ng / ml. 60 minutes after the intramuscular administration of 0.25 mg of ACTE, the level of cortisol was 122 ng / ml (i.e. an increase of less than 2 times). The patient was subjected to surgical treatment.

Пр и м е р 2. Больна  В., 25 лет, диагноз: тиреотоксикоз средней т жести , диффузный зоб III ст. Продолжительность заболевани  3 мес. Исходный уровень кортизола в сыворотке 80 нг/мл, через 60 мин после внутримьшечного ,.введени  0,25 мг АКТГ содержание кортизола увеличилось до 340 нг/мл .(т.е., в 4,25 раза). Больной был назначен мерказолил, резерпин и седативные препараты. Достигнуто зутиреоидное состо ние, которое сохран етс  при минимальной поддерживающей дозе в течение 1 года.Primer 2. Ill. V., 25 years old, diagnosis: moderate thyrotoxicosis, diffuse goiter, stage III. Disease duration 3 months. The initial serum cortisol level was 80 ng / ml, 60 minutes after intramuscular administration, the administration of 0.25 mg of ACTH increased the cortisol content to 340 ng / ml (i.e., 4.25 times). The patient was prescribed Mercazolil, Reserpine and sedatives. A thyroid state has been reached, which is maintained at the minimum maintenance dose for 1 year.

Claims (1)

СПОСОБ -ЛЕЧЕНИЯ БОЛЬНЫХ ТИРЕОТОКСИКОЗОМ путем медикаментозного лечения антитиреоидными средствами, о тличающийся тем, что, с целью снижения осложнений, в крови определяют содержание кортизола до и после введения АКТГ и при увеличении его содержания в 2,0-4,25 раэа в сравнений с исходным уровнем проводят медикаментозное лечение, а при отсутств^ни увеличения проводят хирургическое лечение.METHOD FOR TREATING THYROIDOXICIOSIS PATIENTS by drug treatment with antithyroid drugs, characterized in that, in order to reduce complications, the cortisol content in the blood is determined before and after ACTH administration and with an increase in its content of 2.0-4.25 raea in comparison with the initial the level of drug treatment, and in the absence of ^ no increase conduct surgical treatment. 1 11638621 1163862
SU813282263A 1981-04-21 1981-04-21 Method of testing thyrotoxicosis cases SU1163862A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU813282263A SU1163862A1 (en) 1981-04-21 1981-04-21 Method of testing thyrotoxicosis cases

Applications Claiming Priority (1)

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SU813282263A SU1163862A1 (en) 1981-04-21 1981-04-21 Method of testing thyrotoxicosis cases

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SU1163862A1 true SU1163862A1 (en) 1985-06-30

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SU813282263A SU1163862A1 (en) 1981-04-21 1981-04-21 Method of testing thyrotoxicosis cases

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Хирургическое лечение заболева-; НИИ щитовидной железы. Методические рекомендации. Харьков, 1978. *

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